Recent advances on the use of cyclodextrins in the chiral analysis of drugs by capillary electrophoresis
The most recent advances on the use of cyclodextrins as chiral selectors in capillary electrophoresis for the enantioseparation of drugs are reviewed in this article. The types of cyclodextrins employed and the resolutions achieved are discussed. The use of dual chiral systems, modified capillaries,...
| Autores: | , |
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| Tipo de documento: | artigo |
| Data de publicação: | 2016 |
| País: | España |
| Recursos: | Universidad de Alcalá (UAH) |
| Repositório: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglês |
| OAI Identifier: | oai:ebuah.uah.es:10017/48209 |
| Acesso em linha: | http://hdl.handle.net/10017/48209 https://dx.doi.org/10.1016/j.chroma.2016.08.029 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Chiral Capillary electrophoresis Cyclodextrins Drugs Analysis Enantiomer Química Chemistry |
| Resumo: | The most recent advances on the use of cyclodextrins as chiral selectors in capillary electrophoresis for the enantioseparation of drugs are reviewed in this article. The types of cyclodextrins employed and the resolutions achieved are discussed. The use of dual chiral systems, modified capillaries, non-aqueous media or microfluidic devices is also included and the mechanisms for enantioseparation of drugs and the inversion of the enantiomer migration order are studied. The most relevant applications developed to carry out the quantitation of chiral drugs, to assess the enantiomeric purity of pharmaceutical formulations, to study their metabolism or to achieve criminalistic or forensic investigations are described. Article's published in the last six years (period from 2010 to 2015) are considered. (C) 2016 Elsevier B.V. All rights reserved. |
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