Results of a new patch to externally reinforce colorectal anastomosis: an experimental study
Background: Anastomotic leak (AL) is a serious complication in colorectal surgery, associated with increased morbidity, mortality, and healthcare costs. Technological advances have yet to eliminate AL, which occurs from 5 to 14% of cases involving anastomosis. This study introduces and evaluates a n...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:318398 |
| Acceso en línea: | https://ddd.uab.cat/record/318398 https://dx.doi.org/urn:doi:10.1016/j.jss.2025.07.047 |
| Access Level: | acceso abierto |
| Palabra clave: | Colorectal anastomosis Cyanoacrylate Collagen patch Anastomotic wound healing Anastomotic leakage Experimental Porcine model |
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Results of a new patch to externally reinforce colorectal anastomosis: an experimental studyGené Škrabec, Clara|||0000-0002-7471-2145Cremades, Manel|||0000-0001-8155-546XGatell, LaiaWeis, ChristineIzco, Jesús M.Rodriguez Rivero, Anna MariaZuñiga, TeresaParés, David|||0000-0001-8233-4888Julián Ibáñez, Joan Francesc|||0000-0003-2646-2791Colorectal anastomosisCyanoacrylateCollagen patchAnastomotic wound healingAnastomotic leakageExperimentalPorcine modelBackground: Anastomotic leak (AL) is a serious complication in colorectal surgery, associated with increased morbidity, mortality, and healthcare costs. Technological advances have yet to eliminate AL, which occurs from 5 to 14% of cases involving anastomosis. This study introduces and evaluates a new collagen-cyanoacrylate patch designed to externally reinforce colonic anastomoses with the aim to contain anastomotic leaks. The objective of the study is to evaluate the feasibility and safety of a novel collagen-cyanoacrylate patch to reinforce colonic anastomosis in a porcine model. Materials and Methods: A preclinical study adhering to Good Laboratory Practices (GLP) was conducted on 12 Landrace x Large White pigs. Following a previously validated model for a deficient anastomosis, a 21mm defect was created at a colorectal anastomosis to simulate an AL. Pigs were randomized to receive either reinforcement with the collagencyanoacrylate patch or no reinforcement. Safety and feasibility were assed, analyzing the integration of the patch in colorectal structures. In addition, as a secondary outcomes, we assessed clinical monitoring, behavioral observations, blood tests for inflammatory markers and histopathological analysis. Results: The collagen-cyanoacrylate patch was easily applied, adhered effectively to the bowel surface, successfully sealed the defect, and was naturally degraded during the healing process. No significant differences in stenosis or adhesions were observed between the experimental and control groups, although minor variations in inflammatory and infectious markers were noted. All animals exhibited a 100% survival rate, and no clinical signs of AL were observed. Conclusions: The use of collagen-cyanoacrylate patch is feasible, safe, and has good clinical outcomes, showing promise in preventing colonic AL. Further studies using an adequate anastomotic leak model or clinical studies are needed to confirm efficacy. 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/318398https://dx.doi.org/urn:doi:10.1016/j.jss.2025.07.047reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3183982026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Results of a new patch to externally reinforce colorectal anastomosis: an experimental study |
| title |
Results of a new patch to externally reinforce colorectal anastomosis: an experimental study |
| spellingShingle |
Results of a new patch to externally reinforce colorectal anastomosis: an experimental study Gené Škrabec, Clara|||0000-0002-7471-2145 Colorectal anastomosis Cyanoacrylate Collagen patch Anastomotic wound healing Anastomotic leakage Experimental Porcine model |
| title_short |
Results of a new patch to externally reinforce colorectal anastomosis: an experimental study |
| title_full |
Results of a new patch to externally reinforce colorectal anastomosis: an experimental study |
| title_fullStr |
Results of a new patch to externally reinforce colorectal anastomosis: an experimental study |
| title_full_unstemmed |
Results of a new patch to externally reinforce colorectal anastomosis: an experimental study |
| title_sort |
Results of a new patch to externally reinforce colorectal anastomosis: an experimental study |
| dc.creator.none.fl_str_mv |
Gené Škrabec, Clara|||0000-0002-7471-2145 Cremades, Manel|||0000-0001-8155-546X Gatell, Laia Weis, Christine Izco, Jesús M. Rodriguez Rivero, Anna Maria Zuñiga, Teresa Parés, David|||0000-0001-8233-4888 Julián Ibáñez, Joan Francesc|||0000-0003-2646-2791 |
| author |
Gené Škrabec, Clara|||0000-0002-7471-2145 |
| author_facet |
Gené Škrabec, Clara|||0000-0002-7471-2145 Cremades, Manel|||0000-0001-8155-546X Gatell, Laia Weis, Christine Izco, Jesús M. Rodriguez Rivero, Anna Maria Zuñiga, Teresa Parés, David|||0000-0001-8233-4888 Julián Ibáñez, Joan Francesc|||0000-0003-2646-2791 |
| author_role |
author |
| author2 |
Cremades, Manel|||0000-0001-8155-546X Gatell, Laia Weis, Christine Izco, Jesús M. Rodriguez Rivero, Anna Maria Zuñiga, Teresa Parés, David|||0000-0001-8233-4888 Julián Ibáñez, Joan Francesc|||0000-0003-2646-2791 |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
Colorectal anastomosis Cyanoacrylate Collagen patch Anastomotic wound healing Anastomotic leakage Experimental Porcine model |
| topic |
Colorectal anastomosis Cyanoacrylate Collagen patch Anastomotic wound healing Anastomotic leakage Experimental Porcine model |
| description |
Background: Anastomotic leak (AL) is a serious complication in colorectal surgery, associated with increased morbidity, mortality, and healthcare costs. Technological advances have yet to eliminate AL, which occurs from 5 to 14% of cases involving anastomosis. This study introduces and evaluates a new collagen-cyanoacrylate patch designed to externally reinforce colonic anastomoses with the aim to contain anastomotic leaks. The objective of the study is to evaluate the feasibility and safety of a novel collagen-cyanoacrylate patch to reinforce colonic anastomosis in a porcine model. Materials and Methods: A preclinical study adhering to Good Laboratory Practices (GLP) was conducted on 12 Landrace x Large White pigs. Following a previously validated model for a deficient anastomosis, a 21mm defect was created at a colorectal anastomosis to simulate an AL. Pigs were randomized to receive either reinforcement with the collagencyanoacrylate patch or no reinforcement. Safety and feasibility were assed, analyzing the integration of the patch in colorectal structures. In addition, as a secondary outcomes, we assessed clinical monitoring, behavioral observations, blood tests for inflammatory markers and histopathological analysis. Results: The collagen-cyanoacrylate patch was easily applied, adhered effectively to the bowel surface, successfully sealed the defect, and was naturally degraded during the healing process. No significant differences in stenosis or adhesions were observed between the experimental and control groups, although minor variations in inflammatory and infectious markers were noted. All animals exhibited a 100% survival rate, and no clinical signs of AL were observed. Conclusions: The use of collagen-cyanoacrylate patch is feasible, safe, and has good clinical outcomes, showing promise in preventing colonic AL. Further studies using an adequate anastomotic leak model or clinical studies are needed to confirm efficacy. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2 2025-01-01 2025 2025-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 AM http://purl.org/coar/version/c_ab4af688f83e57aa |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/318398 https://dx.doi.org/urn:doi:10.1016/j.jss.2025.07.047 |
| url |
https://ddd.uab.cat/record/318398 https://dx.doi.org/urn:doi:10.1016/j.jss.2025.07.047 |
| dc.language.none.fl_str_mv |
Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf |
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