Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models

Among procyanidins (PC), monomers, such as catechin and epicatechin, have been widely studied, whereas dimer and trimer oligomers have received much less attention, despite their abundance in our diet. Recent studies have showed that as dimers and trimers could be important in determining the biolog...

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Autores: Serra Maqueda, Aida, Macià i Puig, Ma Alba, Romero Fabregat, Mª Paz, Valls, Josep, Bladé, Cinta, Arola i Ferrer, Lluís, Motilva Casado, Mª José
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/64880
Acceso en línea:https://doi.org/10.1017/S0007114509992741
http://hdl.handle.net/10459.1/64880
Access Level:acceso abierto
Palabra clave:Procyanidins
Dimers
Trimers
Digestion
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spelling Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo modelsSerra Maqueda, AidaMacià i Puig, Ma AlbaRomero Fabregat, Mª PazValls, JosepBladé, CintaArola i Ferrer, LluísMotilva Casado, Mª JoséProcyanidinsDimersTrimersDigestionAmong procyanidins (PC), monomers, such as catechin and epicatechin, have been widely studied, whereas dimer and trimer oligomers have received much less attention, despite their abundance in our diet. Recent studies have showed that as dimers and trimers could be important in determining the biological effects of procyanidin-rich food, understanding their bioavailability and metabolism is fundamental. The purpose of the present work is to study the stability of PC under digestion conditions, the metabolism and the bioavailability by using a combination of in vitro and in vivo models. Simultaneously, the matrix effect of a carbohydrate-rich food on the digestibility and bioavailability of PC is investigated. The results show a high level of stability of PC under gastric and duodenal digestion conditions. However, the pharmacokinetic study revealed limited absorption. Free forms of dimers and trimers have been detected in rat plasma, reaching the maximum concentration 1 h after oral intake of a grape seed extract.The present work was supported by the CENIT program from the Spanish Minister of Industry and by a consortium of companies led by La Morella Nuts S.A. (Reus, Catalonia, Spain) with the following companies: Shirota Functional Foods, S.L.; KRAFT; BTSA, Biotecnologı´as Aplicadas, S.L.; Seleccio ´n Batalle´, S.A.; Industrial Te´cnica Pecuaria, S.A.; Neuron BioPharma, S.A.; Grupo Leche Pascual, S.A.U.; Innaves, S.A. The present work was also supported by the Spanish Ministry of Education and Science financing the project AGL2008-00 387.Cambridge University Press201820182010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1017/S0007114509992741http://hdl.handle.net/10459.1/64880http://hdl.handle.net/10459.1/64880reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglésinfo:eu-repo/grantAgreement/MICINN//AGL2008-00387Reproducció del document publicat a https://doi.org/10.1017/S0007114509992741British Journal of Nutrition, 2010, vol. 103, p. 944-952(c) Cambridge University Press, 2010info:eu-repo/semantics/openAccessoai:recercat.cat:10459.1/648802026-05-29T05:05:01Z
dc.title.none.fl_str_mv Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
title Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
spellingShingle Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
Serra Maqueda, Aida
Procyanidins
Dimers
Trimers
Digestion
title_short Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
title_full Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
title_fullStr Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
title_full_unstemmed Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
title_sort Bioavailability of procyanidin dimers and trimers and matrix food effects in in vitro and in vivo models
dc.creator.none.fl_str_mv Serra Maqueda, Aida
Macià i Puig, Ma Alba
Romero Fabregat, Mª Paz
Valls, Josep
Bladé, Cinta
Arola i Ferrer, Lluís
Motilva Casado, Mª José
author Serra Maqueda, Aida
author_facet Serra Maqueda, Aida
Macià i Puig, Ma Alba
Romero Fabregat, Mª Paz
Valls, Josep
Bladé, Cinta
Arola i Ferrer, Lluís
Motilva Casado, Mª José
author_role author
author2 Macià i Puig, Ma Alba
Romero Fabregat, Mª Paz
Valls, Josep
Bladé, Cinta
Arola i Ferrer, Lluís
Motilva Casado, Mª José
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Procyanidins
Dimers
Trimers
Digestion
topic Procyanidins
Dimers
Trimers
Digestion
description Among procyanidins (PC), monomers, such as catechin and epicatechin, have been widely studied, whereas dimer and trimer oligomers have received much less attention, despite their abundance in our diet. Recent studies have showed that as dimers and trimers could be important in determining the biological effects of procyanidin-rich food, understanding their bioavailability and metabolism is fundamental. The purpose of the present work is to study the stability of PC under digestion conditions, the metabolism and the bioavailability by using a combination of in vitro and in vivo models. Simultaneously, the matrix effect of a carbohydrate-rich food on the digestibility and bioavailability of PC is investigated. The results show a high level of stability of PC under gastric and duodenal digestion conditions. However, the pharmacokinetic study revealed limited absorption. Free forms of dimers and trimers have been detected in rat plasma, reaching the maximum concentration 1 h after oral intake of a grape seed extract.
publishDate 2010
dc.date.none.fl_str_mv 2010
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1017/S0007114509992741
http://hdl.handle.net/10459.1/64880
http://hdl.handle.net/10459.1/64880
url https://doi.org/10.1017/S0007114509992741
http://hdl.handle.net/10459.1/64880
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MICINN//AGL2008-00387
Reproducció del document publicat a https://doi.org/10.1017/S0007114509992741
British Journal of Nutrition, 2010, vol. 103, p. 944-952
dc.rights.none.fl_str_mv (c) Cambridge University Press, 2010
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Cambridge University Press, 2010
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
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