Deep Brain Stimulation lead reconstruction and computer simulation based on neuroimaging for patients with Parkinson’s disease

Parkinson’s disease (PD) is a neurodegenerative disease, the second most common age-related illness after Alzheimer’s disease. According to the Spanish Parkinson’s Federation, Parkinson’s affects 160.000 people in Spain and more than seven million people worldwide. Different types of treatment for t...

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Detalles Bibliográficos
Autor: García Cornet, Júlia
Tipo de recurso: tesis de maestría
Fecha de publicación:2022
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/367175
Acceso en línea:https://hdl.handle.net/2117/367175
Access Level:acceso abierto
Palabra clave:Parkinson's disease
Brain stimulation
Parkinson, Malaltia de
Cervell--Estimulació
Àrees temàtiques de la UPC::Ciències de la salut::Medicina
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spelling Deep Brain Stimulation lead reconstruction and computer simulation based on neuroimaging for patients with Parkinson’s diseaseGarcía Cornet, JúliaParkinson's diseaseBrain stimulationParkinson, Malaltia deCervell--EstimulacióÀrees temàtiques de la UPC::Ciències de la salut::MedicinaParkinson’s disease (PD) is a neurodegenerative disease, the second most common age-related illness after Alzheimer’s disease. According to the Spanish Parkinson’s Federation, Parkinson’s affects 160.000 people in Spain and more than seven million people worldwide. Different types of treatment for this disease exist, all of them resulting in a reduction of Parkinson’s symptoms, but none of them are a cure. Deep brain stimulation (DBS) is one of them; it is a functional surgical technique used since the end of the 20th century that considerably improves the quality of life of patients, especially motor and non-motor fluctuations. PD is one of the main diseases to which the Movement Disorders Unit of the Neurology Service, belonging to the Hospital de la Santa Creu i Sant Pau, is specialized. The aim of this Unit is to improve the quality of life of these patients and, -in collaboration with the Neurology Service- perform DBS surgeries. For the success of this type of surgery, an adequate and precise placement of the leads in the target structures is essential, something demonstrated in different studies. Therefore, this project aimed to analyse in a cohort of 55 patients with DBS the relation between the location of the DBS leads and clinical improvements, using the Matlab toolboxes: Lead DBS and Lead Group. To demonstrate that, it was necessary to review the existing literature from PD and DBS. This was followed by a thorough analysis of Lead DBS software to understand all the options available in the toolbox. With Lead DBS, the leads of all the patients were reconstructed and compared with the gold-standard reconstructions (obtained with the program Brainlab Elements). The toolbox Lead Group was also studied in depth in order to obtain the anatomical regions, networks and white matter tracts that were related to symptoms improvements (sweetspot, network mapping and discriminative fiber analysis, respectively). Finally, the results obtained were compared with the literature, concluding that although the subthalamic nucleus (STN) -and more precisely, the dorsolateral area-, is the main target of the surgery, the patients who had the leads away from the STN but close to the white matter tracts emerging from the STN (the so-called hyperdirect pathway) also showed valuable clinical benefits.Universitat Politècnica de CatalunyaPascual Sedano, Berta MaríaRomero Lafuente, Sergio20222022-05-0320222022-05-10master thesishttp://purl.org/coar/resource_type/c_bdccNAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfhttps://hdl.handle.net/2117/367175reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/3671752026-05-27T15:37:01Z
dc.title.none.fl_str_mv Deep Brain Stimulation lead reconstruction and computer simulation based on neuroimaging for patients with Parkinson’s disease
title Deep Brain Stimulation lead reconstruction and computer simulation based on neuroimaging for patients with Parkinson’s disease
spellingShingle Deep Brain Stimulation lead reconstruction and computer simulation based on neuroimaging for patients with Parkinson’s disease
García Cornet, Júlia
Parkinson's disease
Brain stimulation
Parkinson, Malaltia de
Cervell--Estimulació
Àrees temàtiques de la UPC::Ciències de la salut::Medicina
title_short Deep Brain Stimulation lead reconstruction and computer simulation based on neuroimaging for patients with Parkinson’s disease
title_full Deep Brain Stimulation lead reconstruction and computer simulation based on neuroimaging for patients with Parkinson’s disease
title_fullStr Deep Brain Stimulation lead reconstruction and computer simulation based on neuroimaging for patients with Parkinson’s disease
title_full_unstemmed Deep Brain Stimulation lead reconstruction and computer simulation based on neuroimaging for patients with Parkinson’s disease
title_sort Deep Brain Stimulation lead reconstruction and computer simulation based on neuroimaging for patients with Parkinson’s disease
dc.creator.none.fl_str_mv García Cornet, Júlia
author García Cornet, Júlia
author_facet García Cornet, Júlia
author_role author
dc.contributor.none.fl_str_mv Pascual Sedano, Berta María
Romero Lafuente, Sergio
dc.subject.none.fl_str_mv Parkinson's disease
Brain stimulation
Parkinson, Malaltia de
Cervell--Estimulació
Àrees temàtiques de la UPC::Ciències de la salut::Medicina
topic Parkinson's disease
Brain stimulation
Parkinson, Malaltia de
Cervell--Estimulació
Àrees temàtiques de la UPC::Ciències de la salut::Medicina
description Parkinson’s disease (PD) is a neurodegenerative disease, the second most common age-related illness after Alzheimer’s disease. According to the Spanish Parkinson’s Federation, Parkinson’s affects 160.000 people in Spain and more than seven million people worldwide. Different types of treatment for this disease exist, all of them resulting in a reduction of Parkinson’s symptoms, but none of them are a cure. Deep brain stimulation (DBS) is one of them; it is a functional surgical technique used since the end of the 20th century that considerably improves the quality of life of patients, especially motor and non-motor fluctuations. PD is one of the main diseases to which the Movement Disorders Unit of the Neurology Service, belonging to the Hospital de la Santa Creu i Sant Pau, is specialized. The aim of this Unit is to improve the quality of life of these patients and, -in collaboration with the Neurology Service- perform DBS surgeries. For the success of this type of surgery, an adequate and precise placement of the leads in the target structures is essential, something demonstrated in different studies. Therefore, this project aimed to analyse in a cohort of 55 patients with DBS the relation between the location of the DBS leads and clinical improvements, using the Matlab toolboxes: Lead DBS and Lead Group. To demonstrate that, it was necessary to review the existing literature from PD and DBS. This was followed by a thorough analysis of Lead DBS software to understand all the options available in the toolbox. With Lead DBS, the leads of all the patients were reconstructed and compared with the gold-standard reconstructions (obtained with the program Brainlab Elements). The toolbox Lead Group was also studied in depth in order to obtain the anatomical regions, networks and white matter tracts that were related to symptoms improvements (sweetspot, network mapping and discriminative fiber analysis, respectively). Finally, the results obtained were compared with the literature, concluding that although the subthalamic nucleus (STN) -and more precisely, the dorsolateral area-, is the main target of the surgery, the patients who had the leads away from the STN but close to the white matter tracts emerging from the STN (the so-called hyperdirect pathway) also showed valuable clinical benefits.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-05-03
2022
2022-05-10
dc.type.none.fl_str_mv master thesis
http://purl.org/coar/resource_type/c_bdcc
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/367175
url https://hdl.handle.net/2117/367175
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universitat Politècnica de Catalunya
publisher.none.fl_str_mv Universitat Politècnica de Catalunya
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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