Hydrolytic stability and biocompatibility on smooth muscle cells of polyethylene glycol-polycaprolactone-based polyurethanes

[EN] Interactions between smooth muscle cells (SMCs) and biomaterials must not result in phenotype changes as this may generate uncontrolled multiplication processes and occlusions in vascular grafts. The aim of this study was to relate the hydrolytic stability and biocompatibility of polyurethanes...

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Detalles Bibliográficos
Autores: Morales-Gonzalez, Maria, Arévalo-Alquichire, Said, Diaz, Luis E., Valero, Manuel F., Sans-Tresserras, Juan Ángel|||0000-0001-9047-3992, Vilariño-Feltrer, Guillermo|||0000-0002-3063-3808, Gómez-Tejedor, José-Antonio|||0000-0001-6854-0829
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/172319
Acceso en línea:https://riunet.upv.es/handle/10251/172319
Access Level:acceso abierto
Palabra clave:Hydrolytic stability
Biocompatibility
Polyurethan
Polyethylene glycol-polycaprolactone
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Descripción
Sumario:[EN] Interactions between smooth muscle cells (SMCs) and biomaterials must not result in phenotype changes as this may generate uncontrolled multiplication processes and occlusions in vascular grafts. The aim of this study was to relate the hydrolytic stability and biocompatibility of polyurethanes (PUs) on SMCs. A higher polycaprolactone (PCL) concentration was found to improve the hydrolytic stability of the material and the adhesion of SMCs. A material with 5% polyethylene glycol, 90% PCL, and 5% pentaerythritol presented high cell viability and adhesion, suggesting a contractile phenotype in SMCs depending on the morphology. Nevertheless, all PUs retained their elastic modulus over 120 days, similar to the collagen of native arteries (similar to 10 MPa). Furthermore, aortic SMCs did not present toxicity (viability over 80%) and demonstrated adherence without any abnormal cell multiplication processes, which is ideal for the function to be fulfiled in situ in the vascular grafts.

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