Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates

The datasets generated during the current study are available in the Zenodo repository (https://zenodo.org/records/10977929).

Detalles Bibliográficos
Autores: Balzano, Tiziano, Del Rey, Natalia López-González, Esteban-García, Noelia, Reinares-Sebastián, Alejandro, Pineda-Pardo, José A, Trigo-Damas, Inés, Obeso, José A, Blesa, Javier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/396227
Acceso en línea:http://hdl.handle.net/10261/396227
https://api.elsevier.com/content/abstract/scopus_id/85196115558
Access Level:acceso abierto
Palabra clave:Neuroimmunology
Parkinson's disease
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
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spelling Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primatesBalzano, TizianoDel Rey, Natalia López-GonzálezEsteban-García, NoeliaReinares-Sebastián, AlejandroPineda-Pardo, José ATrigo-Damas, InésObeso, José ABlesa, JavierNeuroimmunologyParkinson's diseasehttp://metadata.un.org/sdg/3Ensure healthy lives and promote well-being for all at all agesThe datasets generated during the current study are available in the Zenodo repository (https://zenodo.org/records/10977929).Dopaminergic neurons in the ventral tier of the substantia nigra pars compacta (SNc) degenerate prominently in Parkinson's disease (PD), while those in the dorsal tier and ventral tegmental area are relatively spared. The factors determining why these neurons are more vulnerable than others are still unrevealed. Neuroinflammation and immune cell infiltration have been demonstrated to be a key feature of neurodegeneration in PD. However, the link between selective dopaminergic neuron vulnerability, glial and immune cell response, and vascularization and their interactions has not been deciphered. We aimed to investigate the contribution of glial cell activation and immune cell infiltration in the selective vulnerability of ventral dopaminergic neurons within the midbrain in a non-human primate model of PD. Structural characteristics of the vasculature within specific regions of the midbrain were also evaluated. Parkinsonian monkeys exhibited significant microglial and astroglial activation in the whole midbrain, but no major sub-regional differences were observed. Remarkably, the ventral substantia nigra was found to be typically more vascularized compared to other regions. This feature might play some role in making this region more susceptible to immune cell infiltration under pathological conditions, as greater infiltration of both T- and B- lymphocytes was observed in parkinsonian monkeys. Higher vascular density within the ventral region of the SNc may be a relevant factor for differential vulnerability of dopaminergic neurons in the midbrain. The increased infiltration of T- and B- cells in this region, alongside other molecules or toxins, may also contribute to the susceptibility of dopaminergic neurons in PD.CP19/00200/Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PI20/00496/Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) PID2019-111045RB-100/Consejería de Educación, Juventud y Deporte, Comunidad de Madrid (Consejería de Educación, Juventud y Deporte de la Comunidad de Madrid) S2017/BMD-3700/Consejería de Educación, Juventud y Deporte, Comunidad de Madrid (Consejería de Educación, Juventud y Deporte de la Comunidad de Madrid)Peer reviewedNature Publishing GroupInstituto de Salud Carlos IIIMinisterio de Economía y Competitividad (España)Comunidad de MadridBalzano, Tiziano [0000-0001-6523-2206]Blesa, Javier [0000-0002-4257-1325]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/396227https://api.elsevier.com/content/abstract/scopus_id/85196115558reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00496info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111045RB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1038/s41531-024-00735-whttps://doi.org/10.1038/s41531-024-00735-wSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3962272026-05-22T06:33:51Z
dc.title.none.fl_str_mv Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
title Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
spellingShingle Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
Balzano, Tiziano
Neuroimmunology
Parkinson's disease
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
title_short Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
title_full Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
title_fullStr Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
title_full_unstemmed Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
title_sort Neurovascular and immune factors of vulnerability of substantia nigra dopaminergic neurons in non-human primates
dc.creator.none.fl_str_mv Balzano, Tiziano
Del Rey, Natalia López-González
Esteban-García, Noelia
Reinares-Sebastián, Alejandro
Pineda-Pardo, José A
Trigo-Damas, Inés
Obeso, José A
Blesa, Javier
author Balzano, Tiziano
author_facet Balzano, Tiziano
Del Rey, Natalia López-González
Esteban-García, Noelia
Reinares-Sebastián, Alejandro
Pineda-Pardo, José A
Trigo-Damas, Inés
Obeso, José A
Blesa, Javier
author_role author
author2 Del Rey, Natalia López-González
Esteban-García, Noelia
Reinares-Sebastián, Alejandro
Pineda-Pardo, José A
Trigo-Damas, Inés
Obeso, José A
Blesa, Javier
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Ministerio de Economía y Competitividad (España)
Comunidad de Madrid
Balzano, Tiziano [0000-0001-6523-2206]
Blesa, Javier [0000-0002-4257-1325]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Neuroimmunology
Parkinson's disease
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
topic Neuroimmunology
Parkinson's disease
http://metadata.un.org/sdg/3
Ensure healthy lives and promote well-being for all at all ages
description The datasets generated during the current study are available in the Zenodo repository (https://zenodo.org/records/10977929).
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/396227
https://api.elsevier.com/content/abstract/scopus_id/85196115558
url http://hdl.handle.net/10261/396227
https://api.elsevier.com/content/abstract/scopus_id/85196115558
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 (ISCIII)/PI20%2F00496
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111045RB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.1038/s41531-024-00735-w
https://doi.org/10.1038/s41531-024-00735-w
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
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