Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients

Introduction: Our goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR). Methods: Serum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (Fl...

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Autores: Cordero, Elisa, Bulnes Ramos, Ángel, Aguilar Guisado, Manuela, González Escribano, Francisca, Olivas, Israel, Torre Cisneros, Julián, Gavaldà, Joan, Aydillo, Teresa, Moreno, Asunción, Montejo, Miguel, Fariñas, María Carmen, Carratalà, Jordi, Muñoz, Patricia, Blanes, Marino, Fortún, Jesús, Suarez Benjumea, Alejandro, López Medrano, Francisco, Roca, Cristina, Lara, Rosario, Pérez Romero, Pilar
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/174213
Acceso en línea:https://hdl.handle.net/2445/174213
Access Level:acceso abierto
Palabra clave:Citomegalovirus
Influenzavirus
Vacunes antivíriques
Cytomegaloviruses
Influenza viruses
Viral vaccines
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spelling Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant RecipientsCordero, ElisaBulnes Ramos, ÁngelAguilar Guisado, ManuelaGonzález Escribano, FranciscaOlivas, IsraelTorre Cisneros, JuliánGavaldà, JoanAydillo, TeresaMoreno, AsunciónMontejo, MiguelFariñas, María CarmenCarratalà, JordiMuñoz, PatriciaBlanes, MarinoFortún, JesúsSuarez Benjumea, AlejandroLópez Medrano, FranciscoRoca, CristinaLara, RosarioPérez Romero, PilarCitomegalovirusInfluenzavirusVacunes antivíriquesCytomegalovirusesInfluenza virusesViral vaccinesIntroduction: Our goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR). Methods: Serum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (FlowPRA(TM)Screening Test) by flow cytometry. Anti-HLA antibody specificity was determined using the single-antigen bead flow cytometry (SAFC) assay and assignation of donor specific antibodies (DSA) was performed by virtual-crossmatch. Results: We studied a cohort of 490 SOTR that received an influenza vaccination from 2009 to 2013: 110 (22.4%) received the pandemic adjuvanted vaccine, 59 (12%) within the first 6 months post-transplantation, 185 (37.7%) more than 6 months after transplantation and 136 (27.7%) received two vaccination doses. Overall, no differences of anti-HLA antibodies were found after immunization in patients that received the adjuvanted vaccine, within the first 6 months post-transplantation, or based on the type of organ transplanted. However, the second immunization dose increased the percentage of patients positive for anti-HLA class I significantly compared with patients with one dose (14.6% vs. 3.8%;P= 0.003). Patients with pre-existing antibodies before vaccination (15.7% for anti-HLA class I and 15.9% for class II) did not increase reactivity after immunization. A group of 75 (14.4%) patients developedde novoanti-HLA antibodies, however, only 5 (1.02%) of them were DSA, and none experienced allograft rejection. Only two (0.4%) patients were diagnosed with graft rejection with favorable outcomes and neither of them developed DSA. Conclusion: Our results suggest that influenza vaccination is not associated with graft rejection in this cohort of SOTR.Frontiers Media2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/174213Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3389/fimmu.2020.01917Frontiers in Immunology, 2020, vol. 11https://doi.org/10.3389/fimmu.2020.01917cc by (c) Cordero et al., 2020http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1742132026-05-27T06:46:51Z
dc.title.none.fl_str_mv Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients
title Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients
spellingShingle Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients
Cordero, Elisa
Citomegalovirus
Influenzavirus
Vacunes antivíriques
Cytomegaloviruses
Influenza viruses
Viral vaccines
title_short Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients
title_full Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients
title_fullStr Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients
title_full_unstemmed Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients
title_sort Effect of Influenza Vaccination Inducing Antibody Mediated Rejection in Solid Organ Transplant Recipients
dc.creator.none.fl_str_mv Cordero, Elisa
Bulnes Ramos, Ángel
Aguilar Guisado, Manuela
González Escribano, Francisca
Olivas, Israel
Torre Cisneros, Julián
Gavaldà, Joan
Aydillo, Teresa
Moreno, Asunción
Montejo, Miguel
Fariñas, María Carmen
Carratalà, Jordi
Muñoz, Patricia
Blanes, Marino
Fortún, Jesús
Suarez Benjumea, Alejandro
López Medrano, Francisco
Roca, Cristina
Lara, Rosario
Pérez Romero, Pilar
author Cordero, Elisa
author_facet Cordero, Elisa
Bulnes Ramos, Ángel
Aguilar Guisado, Manuela
González Escribano, Francisca
Olivas, Israel
Torre Cisneros, Julián
Gavaldà, Joan
Aydillo, Teresa
Moreno, Asunción
Montejo, Miguel
Fariñas, María Carmen
Carratalà, Jordi
Muñoz, Patricia
Blanes, Marino
Fortún, Jesús
Suarez Benjumea, Alejandro
López Medrano, Francisco
Roca, Cristina
Lara, Rosario
Pérez Romero, Pilar
author_role author
author2 Bulnes Ramos, Ángel
Aguilar Guisado, Manuela
González Escribano, Francisca
Olivas, Israel
Torre Cisneros, Julián
Gavaldà, Joan
Aydillo, Teresa
Moreno, Asunción
Montejo, Miguel
Fariñas, María Carmen
Carratalà, Jordi
Muñoz, Patricia
Blanes, Marino
Fortún, Jesús
Suarez Benjumea, Alejandro
López Medrano, Francisco
Roca, Cristina
Lara, Rosario
Pérez Romero, Pilar
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Citomegalovirus
Influenzavirus
Vacunes antivíriques
Cytomegaloviruses
Influenza viruses
Viral vaccines
topic Citomegalovirus
Influenzavirus
Vacunes antivíriques
Cytomegaloviruses
Influenza viruses
Viral vaccines
description Introduction: Our goal was to study whether influenza vaccination induced antibody mediated rejection in a large cohort of solid organ transplant recipients (SOTR). Methods: Serum anti-Human Leukocyte Antigen (HLA) antibodies were determined using class I and class II antibody-coated latex beads (FlowPRA(TM)Screening Test) by flow cytometry. Anti-HLA antibody specificity was determined using the single-antigen bead flow cytometry (SAFC) assay and assignation of donor specific antibodies (DSA) was performed by virtual-crossmatch. Results: We studied a cohort of 490 SOTR that received an influenza vaccination from 2009 to 2013: 110 (22.4%) received the pandemic adjuvanted vaccine, 59 (12%) within the first 6 months post-transplantation, 185 (37.7%) more than 6 months after transplantation and 136 (27.7%) received two vaccination doses. Overall, no differences of anti-HLA antibodies were found after immunization in patients that received the adjuvanted vaccine, within the first 6 months post-transplantation, or based on the type of organ transplanted. However, the second immunization dose increased the percentage of patients positive for anti-HLA class I significantly compared with patients with one dose (14.6% vs. 3.8%;P= 0.003). Patients with pre-existing antibodies before vaccination (15.7% for anti-HLA class I and 15.9% for class II) did not increase reactivity after immunization. A group of 75 (14.4%) patients developedde novoanti-HLA antibodies, however, only 5 (1.02%) of them were DSA, and none experienced allograft rejection. Only two (0.4%) patients were diagnosed with graft rejection with favorable outcomes and neither of them developed DSA. Conclusion: Our results suggest that influenza vaccination is not associated with graft rejection in this cohort of SOTR.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/174213
url https://hdl.handle.net/2445/174213
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2020.01917
Frontiers in Immunology, 2020, vol. 11
https://doi.org/10.3389/fimmu.2020.01917
dc.rights.none.fl_str_mv cc by (c) Cordero et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Cordero et al., 2020
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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