Complejos de Ru(II) con 2,2'-biimidazol para sensores químicos luminiscentes y fotosensibilización de especies reactivas de oxígeno (ROS)
Ru(II) complexes with polyazaheteroaromatic ligands have been widely invertigated since 1959, when the first Ru(II) complex, tris(2,2'-bipyridine)ruthenium(II) [Ru(bpy)3]2+, was described. These metallo-complexes exhibit unique photophysical and photochemical features that make them suitable fo...
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| Formato: | tesis doctoral |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | Universidad Complutense de Madrid (UCM) |
| Repositorio: | Docta Complutense |
| Idioma: | español |
| OAI Identifier: | oai:docta.ucm.es:20.500.14352/91717 |
| Acesso em linha: | https://hdl.handle.net/20.500.14352/91717 |
| Access Level: | acceso abierto |
| Palavra-chave: | 547(043.2) Química orgánica Organic chemistry Química orgánica (Química) 2306 Química Orgánica |
| Resumo: | Ru(II) complexes with polyazaheteroaromatic ligands have been widely invertigated since 1959, when the first Ru(II) complex, tris(2,2'-bipyridine)ruthenium(II) [Ru(bpy)3]2+, was described. These metallo-complexes exhibit unique photophysical and photochemical features that make them suitable for multiple applications in different fields. Their intense luminescence in solution, s-long luminescence lifetimes, high photostability and their ability to generate reactive oxygen species, make these compounds ideal candidates for the development of optical chemical sensors and photosensitization (photodynamic therapies, photodisinfection…). Furthermore, their chemical versatility allows the development of photoactive compounds “on demand” for a particular application by judicious selection of their metal-chelating ligands.Over the past few years, the optical chemical sensors and biosensors technology has notably developed with the aim of improving the population’s quality of life. In particular, food safety has become a major concern for the agricultural sector and the human public health. The presence of contaminants such as microorganisms, pesticides, antibiotics, microplastics or mycotoxins in a large fraction of the food we consume daily is alarming. Hence the European Union efforts to establish maximum residue limits for those contaminants in food and feed. In this regard, food contamination by mycotoxins, secondary metabolites produced by different species of fungi, is a global concern. Exposure to mycotoxins may induce adverse effects on human and animal health, ranging from gastrointestinal and kidney disorders to immune deficiency and cancer. Therefore it is particularly interesting the development of sensitive, selective, straightforward analytical methods for its rapid detection and quantification in situ, without transporting the sample to the laboratory, where expensive techniques such as LC-MS/MS are currently applied for toxin identification and determination... |
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