Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia

Background: A population-based case-control study was designed to assess changes of serum levels of immunoglobulins and IgG subclasses between infected and convalescent phase in community-acquired pneumonia (CAP). Methods: Over a 2-year period, all subjects who were >14 years of age living in the...

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Autores: de la Torre, MC, Bolibar, I, Vendrell, M, de Gracia, J, Vendrell, E, Rodrigo, MJ, Boquet, X, Torrebadella, P, Yebenes, JC, Serra-Prat, M, Rello, J, Torres, A, Almirall, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p9477
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9477
Access Level:acceso abierto
Palabra clave:Community-acquired pneumonia
IgG
IgG subclasses
Immunoglobulins
Prognosis
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spelling Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumoniade la Torre, MCBolibar, IVendrell, Mde Gracia, JVendrell, ERodrigo, MJBoquet, XTorrebadella, PYebenes, JCSerra-Prat, MRello, JTorres, AAlmirall, JCommunity-acquired pneumoniaIgGIgG subclassesImmunoglobulinsPrognosisBackground: A population-based case-control study was designed to assess changes of serum levels of immunoglobulins and IgG subclasses between infected and convalescent phase in community-acquired pneumonia (CAP). Methods: Over a 2-year period, all subjects who were >14 years of age living in the Maresme region (Barcelona, Spain) diagnosed of CAP were registered. Controls were healthy subjects selected from the municipal census. Prognostic factors were assessed and serum levels of total IgG, IgA, IgM, and IgG subclasses were measured at diagnosis and 1 month later (cases). Results: We studied 171 patients with CAP and 90 controls. All immunoglobulins were significantly lower in cases than in controls. At diagnosis, 42.7% of cases showed low levels of some immunologic parameter, mainly total IgG and IgG2. Low immunoglobulin levels at diagnosis were more frequent in patients requiring in-patient care and in those with pneumonia of other etiology than Streptococcus pneumoniae. In the convalescent phase, 26 (23.6%) patients normalized immunological levels. In 27 (24.5%) cases, some parameter with low levels persisted especially in patients with etiology of CAP other than S. pneumoniae. Conclusions: Low serum levels of immunoglobulins particularly total IgG and IgG2 were a common finding in patients with CAP compared to healthy controls. Low immunoglobulin levels may be related to CAP prognosis and persisted in the convalescent phase in one-fourth of cases. (C) 2013 Elsevier Ltd. All rights reserved.W B SAUNDERS CO LTD2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9477RESPIRATORY MEDICINEISSN: 09546111ISSNe: 15323064reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p94772026-06-14T12:41:47Z
dc.title.none.fl_str_mv Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia
title Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia
spellingShingle Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia
de la Torre, MC
Community-acquired pneumonia
IgG
IgG subclasses
Immunoglobulins
Prognosis
title_short Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia
title_full Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia
title_fullStr Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia
title_full_unstemmed Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia
title_sort Serum immunoglobulins in the infected and convalescent phases in community-acquired pneumonia
dc.creator.none.fl_str_mv de la Torre, MC
Bolibar, I
Vendrell, M
de Gracia, J
Vendrell, E
Rodrigo, MJ
Boquet, X
Torrebadella, P
Yebenes, JC
Serra-Prat, M
Rello, J
Torres, A
Almirall, J
author de la Torre, MC
author_facet de la Torre, MC
Bolibar, I
Vendrell, M
de Gracia, J
Vendrell, E
Rodrigo, MJ
Boquet, X
Torrebadella, P
Yebenes, JC
Serra-Prat, M
Rello, J
Torres, A
Almirall, J
author_role author
author2 Bolibar, I
Vendrell, M
de Gracia, J
Vendrell, E
Rodrigo, MJ
Boquet, X
Torrebadella, P
Yebenes, JC
Serra-Prat, M
Rello, J
Torres, A
Almirall, J
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Community-acquired pneumonia
IgG
IgG subclasses
Immunoglobulins
Prognosis
topic Community-acquired pneumonia
IgG
IgG subclasses
Immunoglobulins
Prognosis
description Background: A population-based case-control study was designed to assess changes of serum levels of immunoglobulins and IgG subclasses between infected and convalescent phase in community-acquired pneumonia (CAP). Methods: Over a 2-year period, all subjects who were >14 years of age living in the Maresme region (Barcelona, Spain) diagnosed of CAP were registered. Controls were healthy subjects selected from the municipal census. Prognostic factors were assessed and serum levels of total IgG, IgA, IgM, and IgG subclasses were measured at diagnosis and 1 month later (cases). Results: We studied 171 patients with CAP and 90 controls. All immunoglobulins were significantly lower in cases than in controls. At diagnosis, 42.7% of cases showed low levels of some immunologic parameter, mainly total IgG and IgG2. Low immunoglobulin levels at diagnosis were more frequent in patients requiring in-patient care and in those with pneumonia of other etiology than Streptococcus pneumoniae. In the convalescent phase, 26 (23.6%) patients normalized immunological levels. In 27 (24.5%) cases, some parameter with low levels persisted especially in patients with etiology of CAP other than S. pneumoniae. Conclusions: Low serum levels of immunoglobulins particularly total IgG and IgG2 were a common finding in patients with CAP compared to healthy controls. Low immunoglobulin levels may be related to CAP prognosis and persisted in the convalescent phase in one-fourth of cases. (C) 2013 Elsevier Ltd. All rights reserved.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9477
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=9477
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv W B SAUNDERS CO LTD
publisher.none.fl_str_mv W B SAUNDERS CO LTD
dc.source.none.fl_str_mv RESPIRATORY MEDICINE
ISSN: 09546111
ISSNe: 15323064
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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