Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial

Background: Transcranial direct current stimulation (tDCS) is known to modulate spontaneous neural network excitability. The cognitive improvement observed in previous trials raises the potential of this technique as a possible therapeutic tool for use in attentiondeficit/hyperactivity disorder (ADH...

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Autores: Cosmo, Camila, Ferreira, Candida, Garcia, Jose, Miranda, Vivas, Silva do Rosario, Raphael, Fontes Baptista, Abrahao, Montoya, Pedro, Ponde de Sena, Eduardo
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositorio:Docusalut
Idioma:inglés
OAI Identifier:oai:docusalut.com:20.500.13003/10756
Acesso em linha:https://hdl.handle.net/20.500.13003/10756
Access Level:acceso abierto
Palavra-chave:attention-deficit/hyperactivity disorder
functional cortical networks
transcranial direct current stimulation
spreading effect
dorsolateral prefrontal cortex
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spelling Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trialCosmo, CamilaFerreira, CandidaGarcia, JoseMiranda, VivasSilva do Rosario, RaphaelFontes Baptista, AbrahaoMontoya, PedroPonde de Sena, Eduardoattention-deficit/hyperactivity disorderfunctional cortical networkstranscranial direct current stimulationspreading effectdorsolateral prefrontal cortexBackground: Transcranial direct current stimulation (tDCS) is known to modulate spontaneous neural network excitability. The cognitive improvement observed in previous trials raises the potential of this technique as a possible therapeutic tool for use in attentiondeficit/hyperactivity disorder (ADHD) population. However, to explore the potential of this technique as a treatment approach, the functional parameters of brain connectivity and the extent of its effects need to be more fully investigated. Objective: The aim of this study was to investigate a functional cortical network (FCN) model based on electroencephalographic activity for studying the dynamic patterns of brain connectivity modulated by tDCS and the distribution of its effects in individuals with ADHD. Methods: Sixty ADHD patients participated in a parallel, randomized, double-blind, sham-controlled trial. Individuals underwent a single session of sham or anodal tDCS at 1 mA of current intensity over the left dorsolateral prefrontal cortex for 20 min. The acute effects of stimulation on brain connectivity were assessed using the FCN model based on electroencephalography activity. Results: Comparing the weighted node degree within groups prior to and following the intervention, a statistically significant difference was found in the electrodes located on the target and correlated areas in the active group (p <0.05), while no statistically significant results were found in the sham group (p > 0.05; paired-sample Wilcoxon signed-rank test). Conclusion: Anodal tDCS increased functional brain connectivity in individuals with ADHD compared to data recorded in the baseline resting state. In addition, although some studies have suggested that the effects of tDCS are selective, the present findings show that its modulatory activity spreads. Further studies need to be performed to investigate the dynamic patterns and physiological mechanisms underlying the modulatory effects of tDCS.Frontiers Media Sa20152015-08-0420152015-08-04research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/10756reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/107562026-06-22T12:44:07Z
dc.title.none.fl_str_mv Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial
title Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial
spellingShingle Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial
Cosmo, Camila
attention-deficit/hyperactivity disorder
functional cortical networks
transcranial direct current stimulation
spreading effect
dorsolateral prefrontal cortex
title_short Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial
title_full Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial
title_fullStr Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial
title_full_unstemmed Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial
title_sort Spreading effect of tDCS in individuals with attention-deficit/hyperactivity disorder as shown by functional cortical networks: a randomized, double-blind, sham-controlled trial
dc.creator.none.fl_str_mv Cosmo, Camila
Ferreira, Candida
Garcia, Jose
Miranda, Vivas
Silva do Rosario, Raphael
Fontes Baptista, Abrahao
Montoya, Pedro
Ponde de Sena, Eduardo
author Cosmo, Camila
author_facet Cosmo, Camila
Ferreira, Candida
Garcia, Jose
Miranda, Vivas
Silva do Rosario, Raphael
Fontes Baptista, Abrahao
Montoya, Pedro
Ponde de Sena, Eduardo
author_role author
author2 Ferreira, Candida
Garcia, Jose
Miranda, Vivas
Silva do Rosario, Raphael
Fontes Baptista, Abrahao
Montoya, Pedro
Ponde de Sena, Eduardo
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv attention-deficit/hyperactivity disorder
functional cortical networks
transcranial direct current stimulation
spreading effect
dorsolateral prefrontal cortex
topic attention-deficit/hyperactivity disorder
functional cortical networks
transcranial direct current stimulation
spreading effect
dorsolateral prefrontal cortex
description Background: Transcranial direct current stimulation (tDCS) is known to modulate spontaneous neural network excitability. The cognitive improvement observed in previous trials raises the potential of this technique as a possible therapeutic tool for use in attentiondeficit/hyperactivity disorder (ADHD) population. However, to explore the potential of this technique as a treatment approach, the functional parameters of brain connectivity and the extent of its effects need to be more fully investigated. Objective: The aim of this study was to investigate a functional cortical network (FCN) model based on electroencephalographic activity for studying the dynamic patterns of brain connectivity modulated by tDCS and the distribution of its effects in individuals with ADHD. Methods: Sixty ADHD patients participated in a parallel, randomized, double-blind, sham-controlled trial. Individuals underwent a single session of sham or anodal tDCS at 1 mA of current intensity over the left dorsolateral prefrontal cortex for 20 min. The acute effects of stimulation on brain connectivity were assessed using the FCN model based on electroencephalography activity. Results: Comparing the weighted node degree within groups prior to and following the intervention, a statistically significant difference was found in the electrodes located on the target and correlated areas in the active group (p <0.05), while no statistically significant results were found in the sham group (p > 0.05; paired-sample Wilcoxon signed-rank test). Conclusion: Anodal tDCS increased functional brain connectivity in individuals with ADHD compared to data recorded in the baseline resting state. In addition, although some studies have suggested that the effects of tDCS are selective, the present findings show that its modulatory activity spreads. Further studies need to be performed to investigate the dynamic patterns and physiological mechanisms underlying the modulatory effects of tDCS.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-08-04
2015
2015-08-04
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/10756
url https://hdl.handle.net/20.500.13003/10756
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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