Periodontal disease and cerebral atherosclerotic disease. Translational study

Although an association has been established between periodontal disease (PD) and large vessel ischemic stroke, little is known about the relationship between PD and lacunar infarct (LI), a subtype of cerebral small vessel disease that is responsible for almost 25% of the ischemic stroke cases. Our...

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Detalles Bibliográficos
Autor: Leira Feijóo, Yago
Tipo de recurso: tesis doctoral
Fecha de publicación:2018
País:España
Institución:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/17259
Acceso en línea:http://hdl.handle.net/10347/17259
Access Level:acceso abierto
Palabra clave:Materias::Investigación::32 Ciencias médicas::3207 Patología::320706 Endotoxinas
Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
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spelling Periodontal disease and cerebral atherosclerotic disease. Translational studyLeira Feijóo, YagoMaterias::Investigación::32 Ciencias médicas::3207 Patología::320706 EndotoxinasMaterias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 NeurologíaAlthough an association has been established between periodontal disease (PD) and large vessel ischemic stroke, little is known about the relationship between PD and lacunar infarct (LI), a subtype of cerebral small vessel disease that is responsible for almost 25% of the ischemic stroke cases. Our aim was, therefore, to investigate whether PD is linked with LI and if so, to study potential mechanisms underlying this association. In the present study we found that PD was positively associated with LI and, when present, emerged as one of the main contributors to an enhanced systemic inflammatory state promoting endothelial dysfunction with elevated levels of IL-6, PTX3, sTWEAK, and Aβ1-40 in LI patients. Moreover, moderate to severe active PD was an independent predictor of poor functional outcome in LI patients. These findings were corroborated in a preclinical in vivo study in the rodent model, in which experimental PD induced with lipopolysaccharide from Porphyromonas gingivalis was associated with a mild systemic inflammatory response with disruption of the vascular endothelial function.Blanco Carrión, JuanCastillo Sánchez, José AntonioUniversidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde20182018-01-0120182018-01-01doctoral thesishttp://purl.org/coar/resource_type/c_db06info:eu-repo/semantics/doctoralThesisapplication/pdfhttp://hdl.handle.net/10347/17259reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/172592026-06-15T12:47:27Z
dc.title.none.fl_str_mv Periodontal disease and cerebral atherosclerotic disease. Translational study
title Periodontal disease and cerebral atherosclerotic disease. Translational study
spellingShingle Periodontal disease and cerebral atherosclerotic disease. Translational study
Leira Feijóo, Yago
Materias::Investigación::32 Ciencias médicas::3207 Patología::320706 Endotoxinas
Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
title_short Periodontal disease and cerebral atherosclerotic disease. Translational study
title_full Periodontal disease and cerebral atherosclerotic disease. Translational study
title_fullStr Periodontal disease and cerebral atherosclerotic disease. Translational study
title_full_unstemmed Periodontal disease and cerebral atherosclerotic disease. Translational study
title_sort Periodontal disease and cerebral atherosclerotic disease. Translational study
dc.creator.none.fl_str_mv Leira Feijóo, Yago
author Leira Feijóo, Yago
author_facet Leira Feijóo, Yago
author_role author
dc.contributor.none.fl_str_mv Blanco Carrión, Juan
Castillo Sánchez, José Antonio
Universidade de Santiago de Compostela. Centro Internacional de Estudos de Doutoramento e Avanzados (CIEDUS)
Universidade de Santiago de Compostela. Escola de Doutoramento Internacional en Ciencias da Saúde
dc.subject.none.fl_str_mv Materias::Investigación::32 Ciencias médicas::3207 Patología::320706 Endotoxinas
Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
topic Materias::Investigación::32 Ciencias médicas::3207 Patología::320706 Endotoxinas
Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
description Although an association has been established between periodontal disease (PD) and large vessel ischemic stroke, little is known about the relationship between PD and lacunar infarct (LI), a subtype of cerebral small vessel disease that is responsible for almost 25% of the ischemic stroke cases. Our aim was, therefore, to investigate whether PD is linked with LI and if so, to study potential mechanisms underlying this association. In the present study we found that PD was positively associated with LI and, when present, emerged as one of the main contributors to an enhanced systemic inflammatory state promoting endothelial dysfunction with elevated levels of IL-6, PTX3, sTWEAK, and Aβ1-40 in LI patients. Moreover, moderate to severe active PD was an independent predictor of poor functional outcome in LI patients. These findings were corroborated in a preclinical in vivo study in the rodent model, in which experimental PD induced with lipopolysaccharide from Porphyromonas gingivalis was associated with a mild systemic inflammatory response with disruption of the vascular endothelial function.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv doctoral thesis
http://purl.org/coar/resource_type/c_db06
dc.type.openaire.fl_str_mv info:eu-repo/semantics/doctoralThesis
format doctoralThesis
dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/17259
url http://hdl.handle.net/10347/17259
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
repository.name.fl_str_mv
repository.mail.fl_str_mv
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