Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study

[Introduction] Angiosarcomas constitute approximately 2% to 3% of all soft tissue sarcomas, are characterised by an aggressive clinical behaviour and poor outcome. Optimal management of localised angiosarcomas consists of complete surgical resection with or without radiation. However, due to the inf...

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Autores: Constantinidou, Anastasia, Sauve, Nicolas, Stacchiotti, Silvia, Blay, Jean-Yves, Vincenzi, Bruno, Grignani, Giovanni, Rutkowski, Piotr, Guida, Michele, Hindi, Nadia, Klein, Alexander, Thibaud, Valentin, Sufliarsky, Jozef, Desar, Ingrid, Steeghs, Neeltje, Litiere, Saskia, Gelderblom, Hans, Jones, Robin L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/234191
Acceso en línea:http://hdl.handle.net/10261/234191
Access Level:acceso abierto
Palabra clave:Angiosarcoma
Neoadjuvant
Adjuvant
Sarcoma chemotherapy
Angiosarcoma surgery
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spelling Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre studyConstantinidou, AnastasiaSauve, NicolasStacchiotti, SilviaBlay, Jean-YvesVincenzi, BrunoGrignani, GiovanniRutkowski, PiotrGuida, MicheleHindi, NadiaKlein, AlexanderThibaud, ValentinSufliarsky, JozefDesar, IngridSteeghs, NeeltjeLitiere, SaskiaGelderblom, HansJones, Robin L.AngiosarcomaNeoadjuvantAdjuvantSarcoma chemotherapyAngiosarcoma surgery[Introduction] Angiosarcomas constitute approximately 2% to 3% of all soft tissue sarcomas, are characterised by an aggressive clinical behaviour and poor outcome. Optimal management of localised angiosarcomas consists of complete surgical resection with or without radiation. However, due to the infiltrating nature of this disease, complete resection is often not possible. Despite optimal management, the outcome of patients with localised disease remains poor. The role of (neo)adjuvant chemotherapy in angiosarcomas remains undefined. The aim of this study is to document the outcome of patients treated with (neo)adjuvant chemotherapy and assess the feasibility of performing a prospective trial by evaluating the number of patients treated at sarcoma referral centres.[Methods] A retrospective search within participating EORTC (European Organisation for Research and Treatment of Cancer) sites for patients treated with (neo)adjuvant chemotherapy was made. Patients treated between January 2007 and January 2016 were included.[Results] A total of 15 institutions participated and 86 patients were evaluable, 43 were treated with neoadjuvant, 27 with adjuvant chemotherapy and 16 with both. At the time of analysis, the median follow-up from diagnosis was 4.6 years. Median overall survival (OS) was 4.9 years (2.9 N) and the percentage alive at 4 years was 57.9 (45.5 to 68.4). The median disease-free survival was 1.4 years (0.9 to 1.7) and the percentage disease-free at 4 years was 26.8% (17.9 to 36.5).[Conclusion] The outcome of angiosarcoma patients treated with (neo)adjuvant chemotherapy in this case series compares favourably with previously published data. Due to the aggressive nature of angiosarcoma, a prospective trial of neoadjuvant chemotherapy should be considered.ElsevierConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2021202120202021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/234191reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://doi.org/10.1136/esmoopen-2020-000787Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2341912026-05-22T06:33:51Z
dc.title.none.fl_str_mv Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study
title Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study
spellingShingle Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study
Constantinidou, Anastasia
Angiosarcoma
Neoadjuvant
Adjuvant
Sarcoma chemotherapy
Angiosarcoma surgery
title_short Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study
title_full Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study
title_fullStr Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study
title_full_unstemmed Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study
title_sort Evaluation of the use and efficacy of (neo)adjuvant chemotherapy in angiosarcoma: a multicentre study
dc.creator.none.fl_str_mv Constantinidou, Anastasia
Sauve, Nicolas
Stacchiotti, Silvia
Blay, Jean-Yves
Vincenzi, Bruno
Grignani, Giovanni
Rutkowski, Piotr
Guida, Michele
Hindi, Nadia
Klein, Alexander
Thibaud, Valentin
Sufliarsky, Jozef
Desar, Ingrid
Steeghs, Neeltje
Litiere, Saskia
Gelderblom, Hans
Jones, Robin L.
author Constantinidou, Anastasia
author_facet Constantinidou, Anastasia
Sauve, Nicolas
Stacchiotti, Silvia
Blay, Jean-Yves
Vincenzi, Bruno
Grignani, Giovanni
Rutkowski, Piotr
Guida, Michele
Hindi, Nadia
Klein, Alexander
Thibaud, Valentin
Sufliarsky, Jozef
Desar, Ingrid
Steeghs, Neeltje
Litiere, Saskia
Gelderblom, Hans
Jones, Robin L.
author_role author
author2 Sauve, Nicolas
Stacchiotti, Silvia
Blay, Jean-Yves
Vincenzi, Bruno
Grignani, Giovanni
Rutkowski, Piotr
Guida, Michele
Hindi, Nadia
Klein, Alexander
Thibaud, Valentin
Sufliarsky, Jozef
Desar, Ingrid
Steeghs, Neeltje
Litiere, Saskia
Gelderblom, Hans
Jones, Robin L.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Angiosarcoma
Neoadjuvant
Adjuvant
Sarcoma chemotherapy
Angiosarcoma surgery
topic Angiosarcoma
Neoadjuvant
Adjuvant
Sarcoma chemotherapy
Angiosarcoma surgery
description [Introduction] Angiosarcomas constitute approximately 2% to 3% of all soft tissue sarcomas, are characterised by an aggressive clinical behaviour and poor outcome. Optimal management of localised angiosarcomas consists of complete surgical resection with or without radiation. However, due to the infiltrating nature of this disease, complete resection is often not possible. Despite optimal management, the outcome of patients with localised disease remains poor. The role of (neo)adjuvant chemotherapy in angiosarcomas remains undefined. The aim of this study is to document the outcome of patients treated with (neo)adjuvant chemotherapy and assess the feasibility of performing a prospective trial by evaluating the number of patients treated at sarcoma referral centres.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/234191
url http://hdl.handle.net/10261/234191
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://doi.org/10.1136/esmoopen-2020-000787
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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