Effect of ethanol consumption on colon cancer in an experimental model

Aims: the present study was designed to examine the effect of an ethanol supplement on experimental colon carcinogenesis. Material and methods: one hundred and ten 10-week-old Sprague-Dawley rats were divided into five groups: group A (20 rats) received no treatment. Group B (20 rats) received a sup...

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Autores: Pérez-Holanda Fernández, Sergio, Rodrigo, L., Viñas Salas, Joan, Piñol Felis, Carme
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/60053
Acceso en línea:https://doi.org/10.4321/S1130-01082005000200003
http://hdl.handle.net/10459.1/60053
Access Level:acceso abierto
Palabra clave:Alcohol
Cancer
Carcinogenesis
Colon
Dimethyl- hydrazine
Ethanol
Neoplasm
Tumors
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spelling Effect of ethanol consumption on colon cancer in an experimental modelPérez-Holanda Fernández, SergioRodrigo, L.Viñas Salas, JoanPiñol Felis, CarmeAlcoholCancerCarcinogenesisColonDimethyl- hydrazineEthanolNeoplasmTumorsAims: the present study was designed to examine the effect of an ethanol supplement on experimental colon carcinogenesis. Material and methods: one hundred and ten 10-week-old Sprague-Dawley rats were divided into five groups: group A (20 rats) received no treatment. Group B (20 rats) received a supple- ment of ethanol at 1.23 g/kg of body weight per day added to their drinking water for 24 weeks. Group C (30 rats) received 18 weekly doses of dimethylhydrazine (DMH) at 21 mg/kg of body weight from the beginning of the study. Group D (20 rats) re- ceived ethylen-diamin-tetracetic acid (EDTA) solution only for 18 weeks. Group E (20 rats) received ethanol at the same dose as group B plus DMH injections at the same dose as the rats in group C from the beginning of the study. All experimental ani- mals were sacrified after 25-27 weeks. Results: no significant differences in the number of rats that developed tumors, number of tumor-free animals, and number of tumors per rat, as well as in macro-microscopic tumoral findings were observed for animals in group C compared to animals in group E. Conclusions: we concluded that the addition of an ethanol supplement does not modify colorectal carcinogenesis using a dy- namic model of tumor induction with DMH.Los autores quieren expresar su agradecimiento a D. Manuel Santiago por su ayuda técnica en el manejo y cui- dado de los animales. Este trabajo de investigación ha sido subvencionado por la Universidad de Lleida y con una Beca de “Ayuda a la Investigación FISS Exp. no 89/0612”.Sociedad Española de Patología Digestiva2005info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.4321/S1130-01082005000200003http://hdl.handle.net/10459.1/60053reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a https://doi.org/10.4321/S1130-01082005000200003Revista Española de enfermedades digestivas, 2005, vol. 97, núm. 2, p. 87-96(c) Sociedad Española de Patología Digestiva, 2005info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/600532026-06-24T12:42:17Z
dc.title.none.fl_str_mv Effect of ethanol consumption on colon cancer in an experimental model
title Effect of ethanol consumption on colon cancer in an experimental model
spellingShingle Effect of ethanol consumption on colon cancer in an experimental model
Pérez-Holanda Fernández, Sergio
Alcohol
Cancer
Carcinogenesis
Colon
Dimethyl- hydrazine
Ethanol
Neoplasm
Tumors
title_short Effect of ethanol consumption on colon cancer in an experimental model
title_full Effect of ethanol consumption on colon cancer in an experimental model
title_fullStr Effect of ethanol consumption on colon cancer in an experimental model
title_full_unstemmed Effect of ethanol consumption on colon cancer in an experimental model
title_sort Effect of ethanol consumption on colon cancer in an experimental model
dc.creator.none.fl_str_mv Pérez-Holanda Fernández, Sergio
Rodrigo, L.
Viñas Salas, Joan
Piñol Felis, Carme
author Pérez-Holanda Fernández, Sergio
author_facet Pérez-Holanda Fernández, Sergio
Rodrigo, L.
Viñas Salas, Joan
Piñol Felis, Carme
author_role author
author2 Rodrigo, L.
Viñas Salas, Joan
Piñol Felis, Carme
author2_role author
author
author
dc.subject.none.fl_str_mv Alcohol
Cancer
Carcinogenesis
Colon
Dimethyl- hydrazine
Ethanol
Neoplasm
Tumors
topic Alcohol
Cancer
Carcinogenesis
Colon
Dimethyl- hydrazine
Ethanol
Neoplasm
Tumors
description Aims: the present study was designed to examine the effect of an ethanol supplement on experimental colon carcinogenesis. Material and methods: one hundred and ten 10-week-old Sprague-Dawley rats were divided into five groups: group A (20 rats) received no treatment. Group B (20 rats) received a supple- ment of ethanol at 1.23 g/kg of body weight per day added to their drinking water for 24 weeks. Group C (30 rats) received 18 weekly doses of dimethylhydrazine (DMH) at 21 mg/kg of body weight from the beginning of the study. Group D (20 rats) re- ceived ethylen-diamin-tetracetic acid (EDTA) solution only for 18 weeks. Group E (20 rats) received ethanol at the same dose as group B plus DMH injections at the same dose as the rats in group C from the beginning of the study. All experimental ani- mals were sacrified after 25-27 weeks. Results: no significant differences in the number of rats that developed tumors, number of tumor-free animals, and number of tumors per rat, as well as in macro-microscopic tumoral findings were observed for animals in group C compared to animals in group E. Conclusions: we concluded that the addition of an ethanol supplement does not modify colorectal carcinogenesis using a dy- namic model of tumor induction with DMH.
publishDate 2005
dc.date.none.fl_str_mv 2005
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.4321/S1130-01082005000200003
http://hdl.handle.net/10459.1/60053
url https://doi.org/10.4321/S1130-01082005000200003
http://hdl.handle.net/10459.1/60053
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.4321/S1130-01082005000200003
Revista Española de enfermedades digestivas, 2005, vol. 97, núm. 2, p. 87-96
dc.rights.none.fl_str_mv (c) Sociedad Española de Patología Digestiva, 2005
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Sociedad Española de Patología Digestiva, 2005
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Sociedad Española de Patología Digestiva
publisher.none.fl_str_mv Sociedad Española de Patología Digestiva
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
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repository.mail.fl_str_mv
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