Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain

Purpose: To define importance values assigned to attributes of biological agents (BAs) by Spanish patients with rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis) and rheumatologists. Patients and methods: This was an observational, cross-sectional design base...

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Autores: Nolla Solé, Joan Miquel, Rodríguez Pérez, Manuel, Martín Mola, Emilio, Raya, Enrique, Ibero, Isabel, Nocea, Gonzalo, Aragon, Belén, Lizán, Luis, Prades, Miriam
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/127054
Acceso en línea:https://hdl.handle.net/2445/127054
Access Level:acceso abierto
Palabra clave:Artritis reumatoide
Espondiloartritis anquilosant
Espanya
Reumatologia
Rheumatoid arthritis
Ankylosing spondylitis
Spain
Rheumatology
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spelling Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in SpainNolla Solé, Joan MiquelRodríguez Pérez, ManuelMartín Mola, EmilioRaya, EnriqueIbero, IsabelNocea, GonzaloAragon, BelénLizán, LuisPrades, MiriamArtritis reumatoideEspondiloartritis anquilosantEspanyaReumatologiaRheumatoid arthritisAnkylosing spondylitisSpainRheumatologyPurpose: To define importance values assigned to attributes of biological agents (BAs) by Spanish patients with rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis) and rheumatologists. Patients and methods: This was an observational, cross-sectional design based upon a rank-based full-profile conjoint analysis. A literature review and four focus groups were undertaken to identify attributes and levels. An orthogonal matrix, combining the selected levels of attributes, was used to define scenarios. Participants ranked eight scenarios from 1 (most preferred) to 8 (least preferred). The relative importance (RI) of attributes was calculated. Multivariate regression analysis was performed to identify the characteristics that influenced the values of RI. A total of 488 patients (male 50.9%, mean age 50.6 [standard deviation {SD} 12.06] years, rheumatoid arthritis 33.8%, ankylosing spondylitis 32.4%, psoriatic arthritis 33.8%; mean time since diagnosis 12.6 [SD 8.2] years) and 136 rheumatologists (male 50.4%, mean age 46.4 [SD 9.1] years, mean time of practice 16.7 [SD 8.8] years) participated. Results: The ideal BAs for patients and physicians, respectively, should allow pain relief and improvement of functional capacity (RI 39% and 44.7%), with low risk of adverse events (RI 24.9% and 30.5%), a long time prior to perceiving the need for a new dose (RI 16.4% and 12.4%), and self-administration at home (RI 19.7% and 12.5%), as identified through their preferences. Conclusion: Although efficacy and safety are paramount for patients and rheumatologists to make a choice regarding BAs, the need for a low frequency of administration and the administration method also play a role as preference attributes for BAs.Dove Medical Press2018201820162018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/127054Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.2147/PPA.S106311Patient Preference And Adherence, 2016, vol. 10, p. 1101-1113https://doi.org/10.2147/PPA.S106311cc-by-nc (c) Nolla Solé, Joan Miquel et al., 2016http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1270542026-05-29T05:05:01Z
dc.title.none.fl_str_mv Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain
title Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain
spellingShingle Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain
Nolla Solé, Joan Miquel
Artritis reumatoide
Espondiloartritis anquilosant
Espanya
Reumatologia
Rheumatoid arthritis
Ankylosing spondylitis
Spain
Rheumatology
title_short Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain
title_full Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain
title_fullStr Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain
title_full_unstemmed Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain
title_sort Patients' and rheumatologists' preferences for the attributes of biological agents used in the treatment of rheumatic diseases in Spain
dc.creator.none.fl_str_mv Nolla Solé, Joan Miquel
Rodríguez Pérez, Manuel
Martín Mola, Emilio
Raya, Enrique
Ibero, Isabel
Nocea, Gonzalo
Aragon, Belén
Lizán, Luis
Prades, Miriam
author Nolla Solé, Joan Miquel
author_facet Nolla Solé, Joan Miquel
Rodríguez Pérez, Manuel
Martín Mola, Emilio
Raya, Enrique
Ibero, Isabel
Nocea, Gonzalo
Aragon, Belén
Lizán, Luis
Prades, Miriam
author_role author
author2 Rodríguez Pérez, Manuel
Martín Mola, Emilio
Raya, Enrique
Ibero, Isabel
Nocea, Gonzalo
Aragon, Belén
Lizán, Luis
Prades, Miriam
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Artritis reumatoide
Espondiloartritis anquilosant
Espanya
Reumatologia
Rheumatoid arthritis
Ankylosing spondylitis
Spain
Rheumatology
topic Artritis reumatoide
Espondiloartritis anquilosant
Espanya
Reumatologia
Rheumatoid arthritis
Ankylosing spondylitis
Spain
Rheumatology
description Purpose: To define importance values assigned to attributes of biological agents (BAs) by Spanish patients with rheumatic diseases (rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis) and rheumatologists. Patients and methods: This was an observational, cross-sectional design based upon a rank-based full-profile conjoint analysis. A literature review and four focus groups were undertaken to identify attributes and levels. An orthogonal matrix, combining the selected levels of attributes, was used to define scenarios. Participants ranked eight scenarios from 1 (most preferred) to 8 (least preferred). The relative importance (RI) of attributes was calculated. Multivariate regression analysis was performed to identify the characteristics that influenced the values of RI. A total of 488 patients (male 50.9%, mean age 50.6 [standard deviation {SD} 12.06] years, rheumatoid arthritis 33.8%, ankylosing spondylitis 32.4%, psoriatic arthritis 33.8%; mean time since diagnosis 12.6 [SD 8.2] years) and 136 rheumatologists (male 50.4%, mean age 46.4 [SD 9.1] years, mean time of practice 16.7 [SD 8.8] years) participated. Results: The ideal BAs for patients and physicians, respectively, should allow pain relief and improvement of functional capacity (RI 39% and 44.7%), with low risk of adverse events (RI 24.9% and 30.5%), a long time prior to perceiving the need for a new dose (RI 16.4% and 12.4%), and self-administration at home (RI 19.7% and 12.5%), as identified through their preferences. Conclusion: Although efficacy and safety are paramount for patients and rheumatologists to make a choice regarding BAs, the need for a low frequency of administration and the administration method also play a role as preference attributes for BAs.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/127054
url https://hdl.handle.net/2445/127054
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2147/PPA.S106311
Patient Preference And Adherence, 2016, vol. 10, p. 1101-1113
https://doi.org/10.2147/PPA.S106311
dc.rights.none.fl_str_mv cc-by-nc (c) Nolla Solé, Joan Miquel et al., 2016
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Nolla Solé, Joan Miquel et al., 2016
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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