Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study

Impact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo, by measuring the depth of a micron-sized, spherical tip into cortical bone that is then indexed to the depth of the tip into a reference material. The aim of this study was to define the ref...

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Autores: Rufus-Membere, Pamela, Holloway-Kew, Kara L., Diez-Perez, Adolfo, Appelman-Dijkstra, Natasha M., Bouxsein, Mary L., Eriksen, Erik Fink, Farr, Joshua N., Khosla, Sundeep, Kotowicz, Mark A., Nogués Solán, Xavier, Rubin, Mishaela, Pasco, Julie A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/56926
Acceso en línea:http://hdl.handle.net/10230/56926
http://dx.doi.org/10.1007/s00223-022-01047-y
Access Level:acceso abierto
Palabra clave:Impact microindentation
Reference interval
Osteoporosis
Bone material strength index
Normative data
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spelling Reference intervals for bone impact microindentation in healthy adults: a multi-centre international studyRufus-Membere, PamelaHolloway-Kew, Kara L.Diez-Perez, AdolfoAppelman-Dijkstra, Natasha M.Bouxsein, Mary L.Eriksen, Erik FinkFarr, Joshua N.Khosla, SundeepKotowicz, Mark A.Nogués Solán, XavierRubin, MishaelaPasco, Julie A.Impact microindentationReference intervalOsteoporosisBone material strength indexNormative dataImpact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo, by measuring the depth of a micron-sized, spherical tip into cortical bone that is then indexed to the depth of the tip into a reference material. The aim of this study was to define the reference intervals for men and women by evaluating healthy adults from the United States of America, Europe and Australia. Participants included community-based volunteers and participants drawn from clinical and population-based studies. BMSi was measured on the tibial diaphysis using an OsteoProbe in 479 healthy adults (197 male and 282 female, ages 25 to 98 years) across seven research centres, between 2011 and 2018. Associations between BMSi, age, sex and areal bone mineral density (BMD) were examined following an a posteriori method. Unitless BMSi values ranged from 48 to 101. The mean (± standard deviation) BMSi for men was 84.4 ± 6.9 and for women, 79.0 ± 9.1. Healthy reference intervals for BMSi were identified as 71.0 to 97.9 for men and 59.8 to 95.2 for women. This study provides healthy reference data that can be used to calculate T- and Z-scores for BMSi and assist in determining the utility of BMSi in fracture prediction. These data will be useful for positioning individuals within the population and for identifying those with BMSi at the extremes of the population.Springer202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/56926http://dx.doi.org/10.1007/s00223-022-01047-yreponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCalcified Tissue International. 2023 Mar;112(3):338-49This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/569262026-05-29T05:05:01Z
dc.title.none.fl_str_mv Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study
title Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study
spellingShingle Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study
Rufus-Membere, Pamela
Impact microindentation
Reference interval
Osteoporosis
Bone material strength index
Normative data
title_short Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study
title_full Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study
title_fullStr Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study
title_full_unstemmed Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study
title_sort Reference intervals for bone impact microindentation in healthy adults: a multi-centre international study
dc.creator.none.fl_str_mv Rufus-Membere, Pamela
Holloway-Kew, Kara L.
Diez-Perez, Adolfo
Appelman-Dijkstra, Natasha M.
Bouxsein, Mary L.
Eriksen, Erik Fink
Farr, Joshua N.
Khosla, Sundeep
Kotowicz, Mark A.
Nogués Solán, Xavier
Rubin, Mishaela
Pasco, Julie A.
author Rufus-Membere, Pamela
author_facet Rufus-Membere, Pamela
Holloway-Kew, Kara L.
Diez-Perez, Adolfo
Appelman-Dijkstra, Natasha M.
Bouxsein, Mary L.
Eriksen, Erik Fink
Farr, Joshua N.
Khosla, Sundeep
Kotowicz, Mark A.
Nogués Solán, Xavier
Rubin, Mishaela
Pasco, Julie A.
author_role author
author2 Holloway-Kew, Kara L.
Diez-Perez, Adolfo
Appelman-Dijkstra, Natasha M.
Bouxsein, Mary L.
Eriksen, Erik Fink
Farr, Joshua N.
Khosla, Sundeep
Kotowicz, Mark A.
Nogués Solán, Xavier
Rubin, Mishaela
Pasco, Julie A.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Impact microindentation
Reference interval
Osteoporosis
Bone material strength index
Normative data
topic Impact microindentation
Reference interval
Osteoporosis
Bone material strength index
Normative data
description Impact microindentation (IMI) is a novel technique for assessing bone material strength index (BMSi) in vivo, by measuring the depth of a micron-sized, spherical tip into cortical bone that is then indexed to the depth of the tip into a reference material. The aim of this study was to define the reference intervals for men and women by evaluating healthy adults from the United States of America, Europe and Australia. Participants included community-based volunteers and participants drawn from clinical and population-based studies. BMSi was measured on the tibial diaphysis using an OsteoProbe in 479 healthy adults (197 male and 282 female, ages 25 to 98 years) across seven research centres, between 2011 and 2018. Associations between BMSi, age, sex and areal bone mineral density (BMD) were examined following an a posteriori method. Unitless BMSi values ranged from 48 to 101. The mean (± standard deviation) BMSi for men was 84.4 ± 6.9 and for women, 79.0 ± 9.1. Healthy reference intervals for BMSi were identified as 71.0 to 97.9 for men and 59.8 to 95.2 for women. This study provides healthy reference data that can be used to calculate T- and Z-scores for BMSi and assist in determining the utility of BMSi in fracture prediction. These data will be useful for positioning individuals within the population and for identifying those with BMSi at the extremes of the population.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/56926
http://dx.doi.org/10.1007/s00223-022-01047-y
url http://hdl.handle.net/10230/56926
http://dx.doi.org/10.1007/s00223-022-01047-y
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Calcified Tissue International. 2023 Mar;112(3):338-49
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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