Diabetic microvascular disease in non-classical beds

Diabetes microangiopathy, a hallmark complication of diabetes, is characterised by structural and functional abnormalities within the intricate network of microvessels beyond well-known and documented target organs, i.e., the retina, kidney, and peripheral nerves. Indeed, an intact microvascular bed...

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Autores: Mauricio, Didac|||0000-0002-2868-0250, Gratacòs, Mònica|||0000-0001-7304-7289, Franch-Nadal, Josep|||0000-0002-5175-1555
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:296649
Acceso en línea:https://ddd.uab.cat/record/296649
https://dx.doi.org/urn:doi:10.1186/s12933-023-02056-3
Access Level:acceso abierto
Palabra clave:Diabetes complications
Diabetes mellitus
Diabetic microangiopathy
Diabetic vascular complications
Microcirculation
Microvascular changes
Microvascular complications
Microvessels
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spelling Diabetic microvascular disease in non-classical bedsthe hidden impact beyond the retina, the kidney, and the peripheral nervesMauricio, Didac|||0000-0002-2868-0250Gratacòs, Mònica|||0000-0001-7304-7289Franch-Nadal, Josep|||0000-0002-5175-1555Diabetes complicationsDiabetes mellitusDiabetic microangiopathyDiabetic vascular complicationsMicrocirculationMicrovascular changesMicrovascular complicationsMicrovesselsDiabetes microangiopathy, a hallmark complication of diabetes, is characterised by structural and functional abnormalities within the intricate network of microvessels beyond well-known and documented target organs, i.e., the retina, kidney, and peripheral nerves. Indeed, an intact microvascular bed is crucial for preserving each organ's specific functions and achieving physiological balance to meet their respective metabolic demands. Therefore, diabetes-related microvascular dysfunction leads to widespread multiorgan consequences in still-overlooked non-traditional target organs such as the brain, the lung, the bone tissue, the skin, the arterial wall, the heart, or the musculoskeletal system. All these organs are vulnerable to the physiopathological mechanisms that cause microvascular damage in diabetes (i.e., hyperglycaemia-induced oxidative stress, inflammation, and endothelial dysfunction) and collectively contribute to abnormalities in the microvessels' structure and function, compromising blood flow and tissue perfusion. However, the microcirculatory networks differ between organs due to variations in haemodynamic, vascular architecture, and affected cells, resulting in a spectrum of clinical presentations. The aim of this review is to focus on the multifaceted nature of microvascular impairment in diabetes through available evidence of specific consequences in often overlooked organs. A better understanding of diabetes microangiopathy in non-target organs provides a broader perspective on the systemic nature of the disease, underscoring the importance of recognising the comprehensive range of complications beyond the classic target sites.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/296649https://dx.doi.org/urn:doi:10.1186/s12933-023-02056-3reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 CB15/00071open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2966492026-06-06T12:50:31Z
dc.title.none.fl_str_mv Diabetic microvascular disease in non-classical beds
the hidden impact beyond the retina, the kidney, and the peripheral nerves
title Diabetic microvascular disease in non-classical beds
spellingShingle Diabetic microvascular disease in non-classical beds
Mauricio, Didac|||0000-0002-2868-0250
Diabetes complications
Diabetes mellitus
Diabetic microangiopathy
Diabetic vascular complications
Microcirculation
Microvascular changes
Microvascular complications
Microvessels
title_short Diabetic microvascular disease in non-classical beds
title_full Diabetic microvascular disease in non-classical beds
title_fullStr Diabetic microvascular disease in non-classical beds
title_full_unstemmed Diabetic microvascular disease in non-classical beds
title_sort Diabetic microvascular disease in non-classical beds
dc.creator.none.fl_str_mv Mauricio, Didac|||0000-0002-2868-0250
Gratacòs, Mònica|||0000-0001-7304-7289
Franch-Nadal, Josep|||0000-0002-5175-1555
author Mauricio, Didac|||0000-0002-2868-0250
author_facet Mauricio, Didac|||0000-0002-2868-0250
Gratacòs, Mònica|||0000-0001-7304-7289
Franch-Nadal, Josep|||0000-0002-5175-1555
author_role author
author2 Gratacòs, Mònica|||0000-0001-7304-7289
Franch-Nadal, Josep|||0000-0002-5175-1555
author2_role author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Diabetes complications
Diabetes mellitus
Diabetic microangiopathy
Diabetic vascular complications
Microcirculation
Microvascular changes
Microvascular complications
Microvessels
topic Diabetes complications
Diabetes mellitus
Diabetic microangiopathy
Diabetic vascular complications
Microcirculation
Microvascular changes
Microvascular complications
Microvessels
description Diabetes microangiopathy, a hallmark complication of diabetes, is characterised by structural and functional abnormalities within the intricate network of microvessels beyond well-known and documented target organs, i.e., the retina, kidney, and peripheral nerves. Indeed, an intact microvascular bed is crucial for preserving each organ's specific functions and achieving physiological balance to meet their respective metabolic demands. Therefore, diabetes-related microvascular dysfunction leads to widespread multiorgan consequences in still-overlooked non-traditional target organs such as the brain, the lung, the bone tissue, the skin, the arterial wall, the heart, or the musculoskeletal system. All these organs are vulnerable to the physiopathological mechanisms that cause microvascular damage in diabetes (i.e., hyperglycaemia-induced oxidative stress, inflammation, and endothelial dysfunction) and collectively contribute to abnormalities in the microvessels' structure and function, compromising blood flow and tissue perfusion. However, the microcirculatory networks differ between organs due to variations in haemodynamic, vascular architecture, and affected cells, resulting in a spectrum of clinical presentations. The aim of this review is to focus on the multifaceted nature of microvascular impairment in diabetes through available evidence of specific consequences in often overlooked organs. A better understanding of diabetes microangiopathy in non-target organs provides a broader perspective on the systemic nature of the disease, underscoring the importance of recognising the comprehensive range of complications beyond the classic target sites.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/296649
https://dx.doi.org/urn:doi:10.1186/s12933-023-02056-3
url https://ddd.uab.cat/record/296649
https://dx.doi.org/urn:doi:10.1186/s12933-023-02056-3
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CB15/00071
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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