Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck

Objectives: To determine whether routinary walking activity and the derived neutrophil-to-lymphocyte ratio are associated with outcomes in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck. Methods: This multicenter retrospective cohort study included 64 patients dia...

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Autores: Caballero-Borrego, Miguel|||0000-0002-6105-3750, Piedra, Aida|||0000-0002-4795-1132, Gallego Rubio, Oscar|||0000-0001-5665-0967, López Pousa, Antonio, Castillo, Paola|||0000-0002-9284-8601, Navarrete, Pilar|||0000-0002-0753-4086, Prat, Alba, Grau, Juan Jose|||0000-0001-9967-1223
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:309310
Acceso en línea:https://ddd.uab.cat/record/309310
https://dx.doi.org/urn:doi:10.1016/j.bjorl.2024.101493
Access Level:acceso abierto
Palabra clave:Derived neutrophil-to-lymphocyte ratio
Head and neck cancer
Immunotherapy
Physical activity
Prognosis
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spelling Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neckCaballero-Borrego, Miguel|||0000-0002-6105-3750Piedra, Aida|||0000-0002-4795-1132Gallego Rubio, Oscar|||0000-0001-5665-0967López Pousa, AntonioCastillo, Paola|||0000-0002-9284-8601Navarrete, Pilar|||0000-0002-0753-4086Prat, AlbaGrau, Juan Jose|||0000-0001-9967-1223Derived neutrophil-to-lymphocyte ratioHead and neck cancerImmunotherapyPhysical activityPrognosisObjectives: To determine whether routinary walking activity and the derived neutrophil-to-lymphocyte ratio are associated with outcomes in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck. Methods: This multicenter retrospective cohort study included 64 patients diagnosed with recurrent and/or metastatic squamous cell carcinoma of head and neck and treated with immunotherapy (Programmed Death-1 and Programmed Death-ligand-1 proteins inhibitors) at two tertiary centers. We compared a group that performed uninterrupted physical activity for 1 h per day and controls who performed no activity. The derived neutrophil-to-lymphocyte ratio was calculated as follows: [neutrophils / (leukocytes - neutrophils)]. Progression-free survival and overall survival were evaluated. Results: We included 28 (44%) and 36 (56%) patients in the activity and non-activity groups, respectively. Patient characteristics, treatment details, and tumor Programmed Death-ligand-1 expression were not associated with either progression-free survival or overall survival. Physical activity was an independent beneficial factor for progression-free survival (p < 0.001) and overall survival (p < 0.001). By contrast, a derived neutrophil-to-lymphocyte ratio <3.5 was an independent beneficial factor for overall survival (p = 0.013), but not for progression-free survival (p = 0.328). Conclusions: Walking one hour per day and having a high proportion of lymphocytes to neutrophiles (expressed as a low derived neutrophil-to-lymphocyte ratio) independently predict a better prognosis in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck treated with immunotherapy. Level of evidence: III.Universitat Autònoma de Barcelona 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/309310https://dx.doi.org/urn:doi:10.1016/j.bjorl.2024.101493reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3093102026-06-06T12:50:31Z
dc.title.none.fl_str_mv Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
title Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
spellingShingle Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
Caballero-Borrego, Miguel|||0000-0002-6105-3750
Derived neutrophil-to-lymphocyte ratio
Head and neck cancer
Immunotherapy
Physical activity
Prognosis
title_short Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
title_full Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
title_fullStr Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
title_full_unstemmed Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
title_sort Walking one hour per day and the derived neutrophil-to-lymphocyte ratio are associated with outcome in palliative second-line immunotherapy for patients with recurrent and/or metastatic squamous cell carcinoma of head and neck
dc.creator.none.fl_str_mv Caballero-Borrego, Miguel|||0000-0002-6105-3750
Piedra, Aida|||0000-0002-4795-1132
Gallego Rubio, Oscar|||0000-0001-5665-0967
López Pousa, Antonio
Castillo, Paola|||0000-0002-9284-8601
Navarrete, Pilar|||0000-0002-0753-4086
Prat, Alba
Grau, Juan Jose|||0000-0001-9967-1223
author Caballero-Borrego, Miguel|||0000-0002-6105-3750
author_facet Caballero-Borrego, Miguel|||0000-0002-6105-3750
Piedra, Aida|||0000-0002-4795-1132
Gallego Rubio, Oscar|||0000-0001-5665-0967
López Pousa, Antonio
Castillo, Paola|||0000-0002-9284-8601
Navarrete, Pilar|||0000-0002-0753-4086
Prat, Alba
Grau, Juan Jose|||0000-0001-9967-1223
author_role author
author2 Piedra, Aida|||0000-0002-4795-1132
Gallego Rubio, Oscar|||0000-0001-5665-0967
López Pousa, Antonio
Castillo, Paola|||0000-0002-9284-8601
Navarrete, Pilar|||0000-0002-0753-4086
Prat, Alba
Grau, Juan Jose|||0000-0001-9967-1223
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Derived neutrophil-to-lymphocyte ratio
Head and neck cancer
Immunotherapy
Physical activity
Prognosis
topic Derived neutrophil-to-lymphocyte ratio
Head and neck cancer
Immunotherapy
Physical activity
Prognosis
description Objectives: To determine whether routinary walking activity and the derived neutrophil-to-lymphocyte ratio are associated with outcomes in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck. Methods: This multicenter retrospective cohort study included 64 patients diagnosed with recurrent and/or metastatic squamous cell carcinoma of head and neck and treated with immunotherapy (Programmed Death-1 and Programmed Death-ligand-1 proteins inhibitors) at two tertiary centers. We compared a group that performed uninterrupted physical activity for 1 h per day and controls who performed no activity. The derived neutrophil-to-lymphocyte ratio was calculated as follows: [neutrophils / (leukocytes - neutrophils)]. Progression-free survival and overall survival were evaluated. Results: We included 28 (44%) and 36 (56%) patients in the activity and non-activity groups, respectively. Patient characteristics, treatment details, and tumor Programmed Death-ligand-1 expression were not associated with either progression-free survival or overall survival. Physical activity was an independent beneficial factor for progression-free survival (p < 0.001) and overall survival (p < 0.001). By contrast, a derived neutrophil-to-lymphocyte ratio <3.5 was an independent beneficial factor for overall survival (p = 0.013), but not for progression-free survival (p = 0.328). Conclusions: Walking one hour per day and having a high proportion of lymphocytes to neutrophiles (expressed as a low derived neutrophil-to-lymphocyte ratio) independently predict a better prognosis in patients with recurrent and/or metastatic squamous cell carcinoma of head and neck treated with immunotherapy. Level of evidence: III.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/309310
https://dx.doi.org/urn:doi:10.1016/j.bjorl.2024.101493
url https://ddd.uab.cat/record/309310
https://dx.doi.org/urn:doi:10.1016/j.bjorl.2024.101493
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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