Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)

11 páginas, 5 figuras, 1 tabla.

Detalles Bibliográficos
Autores: Arrazuria, R., Pérez Pérez, Valentín, Molina, Elena, Juste, Ramón A., Khafipour, E, Elguezabal, Natalia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/178791
Acceso en línea:http://hdl.handle.net/10261/178791
Access Level:acceso abierto
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spelling Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)Arrazuria, R.Pérez Pérez, ValentínMolina, ElenaJuste, Ramón A.Khafipour, EElguezabal, Natalia11 páginas, 5 figuras, 1 tabla.The gut associated lymphoid tissue (GALT) is the largest immune organ of the body. Although the gut transient and mucosa-associated microbiota have been largely studied, the microbiota that colonizes the GALT has received less attention. The gut microbiome plays an important role in competitive exclusion of pathogens and in development and maturation of immunity. Diet is a key factor afecting the microbiota composition in the digestive tract. To investigate the relation between diet, microbiota and GALT, microbial and cell composition of vermiform appendix (VA) and sacculus rotundus (SR) were studied in two groups of New Zealand white rabbits on diferent diets. Diet shifted the lymphoid tissue microbiota afecting the presence and/or absence of certain taxa and their abundances. Immunohistochemistry revealed that a higher fbre content diet resulted in M cell hyperplasia and an increase of recently recruited macrophages, whereas T-cell levels remained unaltered in animals on both high fbre and standard diets. These fndings indicate that diet has an impact on the microbiota and cell composition of the GALT, which could act as an important microbial recognition site where interactions with benefcial bacteria can take place favouring microbiota replacement after digestive dysregulations.Authors thank Félix Blanco, Sergio Ayuso and Fidel Goiri for animal care and handling. Te research was funded by grant (AGL2012-39818-C02-02) from the Spanish Ministry of Economy and Competiveness (MINECO), and by the Department of Economy and Infrastructures (DEI) of the Basque Government. RA held a pre-doctoral fellowship (BFI-2012-237) and a visiting fellowship (EP_2015_1_53) from the Department of Education, Universities and Research of the Basque Government.Peer reviewedSpringer NatureMinisterio de Economía y Competitividad (España)Eusko JaurlaritzaPérez Pérez, Valentín [0000-0003-0075-1587]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/178791reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1038/s41598-018-32484-1Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1787912026-05-22T06:33:51Z
dc.title.none.fl_str_mv Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)
title Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)
spellingShingle Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)
Arrazuria, R.
title_short Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)
title_full Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)
title_fullStr Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)
title_full_unstemmed Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)
title_sort Diet induced changes in the microbiota and cell composition of rabbit gut associated lymphoid tissue (GALT)
dc.creator.none.fl_str_mv Arrazuria, R.
Pérez Pérez, Valentín
Molina, Elena
Juste, Ramón A.
Khafipour, E
Elguezabal, Natalia
author Arrazuria, R.
author_facet Arrazuria, R.
Pérez Pérez, Valentín
Molina, Elena
Juste, Ramón A.
Khafipour, E
Elguezabal, Natalia
author_role author
author2 Pérez Pérez, Valentín
Molina, Elena
Juste, Ramón A.
Khafipour, E
Elguezabal, Natalia
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Eusko Jaurlaritza
Pérez Pérez, Valentín [0000-0003-0075-1587]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description 11 páginas, 5 figuras, 1 tabla.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/178791
url http://hdl.handle.net/10261/178791
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1038/s41598-018-32484-1
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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