Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents

Abstract Background. This study investigates the impact of childhood maltreatment (CM) on hypothalamic- pituitary-adrenal (HPA)-axis functioning and on anxiety perception. Moreover, the influence of CM severity and frequency was also explored. Methods. In total, 187 participants aged 7-17 were asses...

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Autores: Marques-Feixa, Laia, Palma-Gudiel, Helena, Romero, Soledad, Moya-Higueras, Jorge, Rapado-Castro, Marta, Castro Quintas, Águeda, Zorrilla, Iñaki, José Muñoz, María, Ramírez, Maite, Mayoral, María, Mas, Ariadna, José Lobato, María, Blasco-Fontecilla, Hilario, Fañanás Saura, Lourdes, EPI-Young Stress GROUP.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/180986
Acceso en línea:https://hdl.handle.net/2445/180986
Access Level:acceso abierto
Palabra clave:Maltractament infantil
Psicopatologia
Ansietat
Child abuse
Pathological psychology
Anxiety
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spelling Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescentsMarques-Feixa, LaiaPalma-Gudiel, HelenaRomero, SoledadMoya-Higueras, JorgeRapado-Castro, MartaCastro Quintas, ÁguedaZorrilla, IñakiJosé Muñoz, MaríaRamírez, MaiteMayoral, MaríaMas, AriadnaJosé Lobato, MaríaBlasco-Fontecilla, HilarioFañanás Saura, LourdesEPI-Young Stress GROUP.Maltractament infantilPsicopatologiaAnsietatChild abusePathological psychologyAnxietyAbstract Background. This study investigates the impact of childhood maltreatment (CM) on hypothalamic- pituitary-adrenal (HPA)-axis functioning and on anxiety perception. Moreover, the influence of CM severity and frequency was also explored. Methods. In total, 187 participants aged 7-17 were assessed for CM history using validated questionnaires and ad hoc interviews to be classified according to the criteria of the Tool for Assessing the Severity of Situations in which Children are Vulnerable (TASSCV). Psychopathology was ascertained using the K-SADS-PL5. To assess HPA-axis functioning, salivary cortisol samples were collected throughout a normal day and during an acute psychosocial stressor, the Trier Social Stress Test for children (TSST-C). Subjective anxiety was evaluated using STAI/-C. Results. Youth with a CM history had higher overall diurnal cortisol levels ( p = 0.001), blunted cortisol response to acute psychosocial stress ( p = 0.002) and greater perceived anxiety ( p = 0.003), than those without CM. Specifically, participants exposed to moderate/severe or often/frequent CM showed the greater diurnal cortisol output ( pseverity = 0.002; pfrequency = 0.003), and blunted cortisol response during the TSST-C ( pseverity = 0.006; pfrequency = 0.008). Meanwhile, youth with low CM severity/frequency exhibited a similar cortisol response to those without CM. However, perceived anxiety was higher in those exposed to CM ( p < 0.001), regardless of its severity/frequency. Conclusions. Disturbances in HPA-axis functioning are already evident early after CM exposure, while psychological and physiological responses to an acute stressor are dissociated in youth exposed to CM. The dose-response relationship described in this paper highlights the need to comprehensively evaluate CM so that vulnerable children can be identified and assigned to proper interventions.Cambridge University Press2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/180986Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1017/S003329172100249XPsychological Medicine, 2021, p. 1-14https://doi.org/10.1017/S003329172100249Xcc by (c) Marques-Feixa, Laia et al., 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1809862026-05-27T06:46:51Z
dc.title.none.fl_str_mv Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
title Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
spellingShingle Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
Marques-Feixa, Laia
Maltractament infantil
Psicopatologia
Ansietat
Child abuse
Pathological psychology
Anxiety
title_short Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
title_full Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
title_fullStr Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
title_full_unstemmed Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
title_sort Childhood maltreatment disrupts HPA-axis activity under basal and stress conditions in a dose-response relationship in children and adolescents
dc.creator.none.fl_str_mv Marques-Feixa, Laia
Palma-Gudiel, Helena
Romero, Soledad
Moya-Higueras, Jorge
Rapado-Castro, Marta
Castro Quintas, Águeda
Zorrilla, Iñaki
José Muñoz, María
Ramírez, Maite
Mayoral, María
Mas, Ariadna
José Lobato, María
Blasco-Fontecilla, Hilario
Fañanás Saura, Lourdes
EPI-Young Stress GROUP.
author Marques-Feixa, Laia
author_facet Marques-Feixa, Laia
Palma-Gudiel, Helena
Romero, Soledad
Moya-Higueras, Jorge
Rapado-Castro, Marta
Castro Quintas, Águeda
Zorrilla, Iñaki
José Muñoz, María
Ramírez, Maite
Mayoral, María
Mas, Ariadna
José Lobato, María
Blasco-Fontecilla, Hilario
Fañanás Saura, Lourdes
EPI-Young Stress GROUP.
author_role author
author2 Palma-Gudiel, Helena
Romero, Soledad
Moya-Higueras, Jorge
Rapado-Castro, Marta
Castro Quintas, Águeda
Zorrilla, Iñaki
José Muñoz, María
Ramírez, Maite
Mayoral, María
Mas, Ariadna
José Lobato, María
Blasco-Fontecilla, Hilario
Fañanás Saura, Lourdes
EPI-Young Stress GROUP.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Maltractament infantil
Psicopatologia
Ansietat
Child abuse
Pathological psychology
Anxiety
topic Maltractament infantil
Psicopatologia
Ansietat
Child abuse
Pathological psychology
Anxiety
description Abstract Background. This study investigates the impact of childhood maltreatment (CM) on hypothalamic- pituitary-adrenal (HPA)-axis functioning and on anxiety perception. Moreover, the influence of CM severity and frequency was also explored. Methods. In total, 187 participants aged 7-17 were assessed for CM history using validated questionnaires and ad hoc interviews to be classified according to the criteria of the Tool for Assessing the Severity of Situations in which Children are Vulnerable (TASSCV). Psychopathology was ascertained using the K-SADS-PL5. To assess HPA-axis functioning, salivary cortisol samples were collected throughout a normal day and during an acute psychosocial stressor, the Trier Social Stress Test for children (TSST-C). Subjective anxiety was evaluated using STAI/-C. Results. Youth with a CM history had higher overall diurnal cortisol levels ( p = 0.001), blunted cortisol response to acute psychosocial stress ( p = 0.002) and greater perceived anxiety ( p = 0.003), than those without CM. Specifically, participants exposed to moderate/severe or often/frequent CM showed the greater diurnal cortisol output ( pseverity = 0.002; pfrequency = 0.003), and blunted cortisol response during the TSST-C ( pseverity = 0.006; pfrequency = 0.008). Meanwhile, youth with low CM severity/frequency exhibited a similar cortisol response to those without CM. However, perceived anxiety was higher in those exposed to CM ( p < 0.001), regardless of its severity/frequency. Conclusions. Disturbances in HPA-axis functioning are already evident early after CM exposure, while psychological and physiological responses to an acute stressor are dissociated in youth exposed to CM. The dose-response relationship described in this paper highlights the need to comprehensively evaluate CM so that vulnerable children can be identified and assigned to proper interventions.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/180986
url https://hdl.handle.net/2445/180986
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1017/S003329172100249X
Psychological Medicine, 2021, p. 1-14
https://doi.org/10.1017/S003329172100249X
dc.rights.none.fl_str_mv cc by (c) Marques-Feixa, Laia et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Marques-Feixa, Laia et al., 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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