The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects

Background: Depressed patients with early traumatic experiences may represent a clinically and biologically distinct subtype, with worse clinical outcomes and greater risk of suicide. Since early traumatic experiences alter development of systems that regulate the stress response, increasing sensiti...

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Autores: dal Santo, Francesco, Carballo Belloso, Juan José, Velasco, Ángela, Jiménez-Treviño, Luís, Rodríguez-Revuelta, Julia, Martínez-Cao, Clara, de la Fuente-Tomás, Lorena, Menéndez-Miranda, Isabel, González-Blanco, Leticia, García-Portilla, Mª Paz, Bobes, Julio, Sáiz, Pilar A., Caro Cañizares, Irene
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad a Distancia de Madrid (UDIMA)
Repositorio:udiMundus. Repositorio Institucional de la Universidad a Distancia de Madrid
OAI Identifier:oai:udimundus.udima.es:20.500.12226/520
Acceso en línea:http://hdl.handle.net/20.500.12226/520
https://doi.org/10.3389/fpsyt.2020.538172
Access Level:acceso abierto
Palabra clave:suicidal behavior
stressful life events
childhood trauma
impulsivity
depression
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spelling The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjectsdal Santo, FrancescoCarballo Belloso, Juan JoséVelasco, ÁngelaJiménez-Treviño, LuísRodríguez-Revuelta, JuliaMartínez-Cao, Clarade la Fuente-Tomás, LorenaMenéndez-Miranda, IsabelGonzález-Blanco, LeticiaGarcía-Portilla, Mª PazBobes, JulioSáiz, Pilar A.Caro Cañizares, Irenesuicidal behaviorstressful life eventschildhood traumaimpulsivitydepressionBackground: Depressed patients with early traumatic experiences may represent a clinically and biologically distinct subtype, with worse clinical outcomes and greater risk of suicide. Since early traumatic experiences alter development of systems that regulate the stress response, increasing sensitivity to stress and mood disorders later in life, certain personality features may influence coping strategies, putting individuals with depression and a history of early traumatic experiences at greater risk of suicidal behavior.Objective: To determine whether impulsivity mediates the relationship between early traumatic experiences and suicidal behavior in patients with major depressive disorder (MDD).Methods: The total sample consists of 190 patients [mean age (SD) = 53.71 (10.37); females: 66.3%], with current MDD (DSM-5 criteria). The Childhood Trauma Questionnaire-Short Form (CTQ-SF), the List of Threatening Experiences (LTE), and the Barratt Impulsiveness Scale-11 (BIS-11) were used to assess childhood and adulthood adverse life events and impulsivity, respectively. We developed mediation models by bootstrap sampling methods.Results: Eighty-one (42.6%) patients had a history of previous suicide attempts (SA). CTQ-SF-Total and BIS-11-Total scores were significantly higher in MDD patients with previous SA. Correlation analyses revealed significant correlations between the CTQ-SF-Total and BIS-11-Total, CTQ-SF-Total and HDRS-Total, and BIS-11-Total and HDRS-Total scores. Regression models found that CTQ-SF-Total, BIS-11-Total, and HDRS-Total scores were associated with SA. Mediation analyses further revealed the association between CTQ-SF-Total and SA was mediated by the indirect effect of the BIS-11-Total score (b = 0.007, 95% CI = 0.001, 0.015), after statistically controlling for sex, the HDRS-Total, and the LTE-Total.Discussion: Data suggest that impulsivity could mediate the influence of childhood trauma on suicidal behavior. This will help understand the role of risk factors in suicidal behavior and aid in the development of prevention interventions focused on modifiable mediators when risk factors are non-modifiable.2020-21Departamento de Psicología y SaludFacultad de Ciencias de la Salud y de la Educación2020info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12226/520https://doi.org/10.3389/fpsyt.2020.538172reponame:udiMundus. Repositorio Institucional de la Universidad a Distancia de Madridinstname:Universidad a Distancia de Madrid (UDIMA)Inglésinfo:eu-repo/semantics/openAccessoai:udimundus.udima.es:20.500.12226/5202026-06-02T12:44:31Z
dc.title.none.fl_str_mv The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects
title The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects
spellingShingle The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects
dal Santo, Francesco
suicidal behavior
stressful life events
childhood trauma
impulsivity
depression
title_short The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects
title_full The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects
title_fullStr The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects
title_full_unstemmed The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects
title_sort The Mediating Role of Impulsivity in the Relationship Between Suicidal Behavior and Early Traumatic Experiences in Depressed Subjects
dc.creator.none.fl_str_mv dal Santo, Francesco
Carballo Belloso, Juan José
Velasco, Ángela
Jiménez-Treviño, Luís
Rodríguez-Revuelta, Julia
Martínez-Cao, Clara
de la Fuente-Tomás, Lorena
Menéndez-Miranda, Isabel
González-Blanco, Leticia
García-Portilla, Mª Paz
Bobes, Julio
Sáiz, Pilar A.
Caro Cañizares, Irene
author dal Santo, Francesco
author_facet dal Santo, Francesco
Carballo Belloso, Juan José
Velasco, Ángela
Jiménez-Treviño, Luís
Rodríguez-Revuelta, Julia
Martínez-Cao, Clara
de la Fuente-Tomás, Lorena
Menéndez-Miranda, Isabel
González-Blanco, Leticia
García-Portilla, Mª Paz
Bobes, Julio
Sáiz, Pilar A.
Caro Cañizares, Irene
author_role author
author2 Carballo Belloso, Juan José
Velasco, Ángela
Jiménez-Treviño, Luís
Rodríguez-Revuelta, Julia
Martínez-Cao, Clara
de la Fuente-Tomás, Lorena
Menéndez-Miranda, Isabel
González-Blanco, Leticia
García-Portilla, Mª Paz
Bobes, Julio
Sáiz, Pilar A.
Caro Cañizares, Irene
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv suicidal behavior
stressful life events
childhood trauma
impulsivity
depression
topic suicidal behavior
stressful life events
childhood trauma
impulsivity
depression
description Background: Depressed patients with early traumatic experiences may represent a clinically and biologically distinct subtype, with worse clinical outcomes and greater risk of suicide. Since early traumatic experiences alter development of systems that regulate the stress response, increasing sensitivity to stress and mood disorders later in life, certain personality features may influence coping strategies, putting individuals with depression and a history of early traumatic experiences at greater risk of suicidal behavior.Objective: To determine whether impulsivity mediates the relationship between early traumatic experiences and suicidal behavior in patients with major depressive disorder (MDD).Methods: The total sample consists of 190 patients [mean age (SD) = 53.71 (10.37); females: 66.3%], with current MDD (DSM-5 criteria). The Childhood Trauma Questionnaire-Short Form (CTQ-SF), the List of Threatening Experiences (LTE), and the Barratt Impulsiveness Scale-11 (BIS-11) were used to assess childhood and adulthood adverse life events and impulsivity, respectively. We developed mediation models by bootstrap sampling methods.Results: Eighty-one (42.6%) patients had a history of previous suicide attempts (SA). CTQ-SF-Total and BIS-11-Total scores were significantly higher in MDD patients with previous SA. Correlation analyses revealed significant correlations between the CTQ-SF-Total and BIS-11-Total, CTQ-SF-Total and HDRS-Total, and BIS-11-Total and HDRS-Total scores. Regression models found that CTQ-SF-Total, BIS-11-Total, and HDRS-Total scores were associated with SA. Mediation analyses further revealed the association between CTQ-SF-Total and SA was mediated by the indirect effect of the BIS-11-Total score (b = 0.007, 95% CI = 0.001, 0.015), after statistically controlling for sex, the HDRS-Total, and the LTE-Total.Discussion: Data suggest that impulsivity could mediate the influence of childhood trauma on suicidal behavior. This will help understand the role of risk factors in suicidal behavior and aid in the development of prevention interventions focused on modifiable mediators when risk factors are non-modifiable.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12226/520
https://doi.org/10.3389/fpsyt.2020.538172
url http://hdl.handle.net/20.500.12226/520
https://doi.org/10.3389/fpsyt.2020.538172
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Departamento de Psicología y Salud
Facultad de Ciencias de la Salud y de la Educación
publisher.none.fl_str_mv Departamento de Psicología y Salud
Facultad de Ciencias de la Salud y de la Educación
dc.source.none.fl_str_mv reponame:udiMundus. Repositorio Institucional de la Universidad a Distancia de Madrid
instname:Universidad a Distancia de Madrid (UDIMA)
instname_str Universidad a Distancia de Madrid (UDIMA)
reponame_str udiMundus. Repositorio Institucional de la Universidad a Distancia de Madrid
collection udiMundus. Repositorio Institucional de la Universidad a Distancia de Madrid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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