Insulin degradation by adipose tissue is increased in human obesity
White adipose tissue samples from obese and lean patients were used for the estimation ofinsulin protease and insulin:glutathione transhydrogenase using 1251-labeled insulin. There was no activity detected in the absence of reduced glutathione, which indicates that insulin is cleaved in human adipos...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 1995 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/22382 |
| Acceso en línea: | https://hdl.handle.net/2445/22382 |
| Access Level: | acceso abierto |
| Palabra clave: | Insulina Obesitat Insulin Obesity |
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Insulin degradation by adipose tissue is increased in human obesityRafecas Jorba, ImmaculadaFernández López, José AntonioSalinas, IsabelFormiguera Sala, X.Remesar Betlloch, XavierFoz Sala, M. (Màrius)Alemany, Marià, 1946-InsulinaObesitatInsulinObesityWhite adipose tissue samples from obese and lean patients were used for the estimation ofinsulin protease and insulin:glutathione transhydrogenase using 1251-labeled insulin. There was no activity detected in the absence of reduced glutathione, which indicates that insulin is cleaved in human adipose "tissue through reduction of the disulfide bridge between the chains. O bese patients showed higher transhydrogenase activity (per U tissue protein wt, per U tissue wt, and in the total adipose tissue mass) than the lean group. There is a significant correlation between the activity per U tissue wt, and protein and total activity in the whole adipose tissue with respect to body mass index, with a higher activity in obese patients. The potential ofinsulin cleavage by adipose tissue in obese patients was a mean 5.6-fold higher than that in controla. The coexistence of high insulinemia and high cleavage capability implies that insulin secretion and turnover are increased in the o bese. Thus, white adipose tissue may be crucial in the control of energy availability through modulation ofinsulin cleavage.The Endocrine Society1995info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2445/22382Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1210/jc.80.2.693Journal of Clinical Endocrinology and Metabolism, 1995, vol. 80, p. 693-695http://dx.doi.org/10.1210/jc.80.2.693(c) The Endocrine Society, 1995info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/223822026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Insulin degradation by adipose tissue is increased in human obesity |
| title |
Insulin degradation by adipose tissue is increased in human obesity |
| spellingShingle |
Insulin degradation by adipose tissue is increased in human obesity Rafecas Jorba, Immaculada Insulina Obesitat Insulin Obesity |
| title_short |
Insulin degradation by adipose tissue is increased in human obesity |
| title_full |
Insulin degradation by adipose tissue is increased in human obesity |
| title_fullStr |
Insulin degradation by adipose tissue is increased in human obesity |
| title_full_unstemmed |
Insulin degradation by adipose tissue is increased in human obesity |
| title_sort |
Insulin degradation by adipose tissue is increased in human obesity |
| dc.creator.none.fl_str_mv |
Rafecas Jorba, Immaculada Fernández López, José Antonio Salinas, Isabel Formiguera Sala, X. Remesar Betlloch, Xavier Foz Sala, M. (Màrius) Alemany, Marià, 1946- |
| author |
Rafecas Jorba, Immaculada |
| author_facet |
Rafecas Jorba, Immaculada Fernández López, José Antonio Salinas, Isabel Formiguera Sala, X. Remesar Betlloch, Xavier Foz Sala, M. (Màrius) Alemany, Marià, 1946- |
| author_role |
author |
| author2 |
Fernández López, José Antonio Salinas, Isabel Formiguera Sala, X. Remesar Betlloch, Xavier Foz Sala, M. (Màrius) Alemany, Marià, 1946- |
| author2_role |
author author author author author author |
| dc.subject.none.fl_str_mv |
Insulina Obesitat Insulin Obesity |
| topic |
Insulina Obesitat Insulin Obesity |
| description |
White adipose tissue samples from obese and lean patients were used for the estimation ofinsulin protease and insulin:glutathione transhydrogenase using 1251-labeled insulin. There was no activity detected in the absence of reduced glutathione, which indicates that insulin is cleaved in human adipose "tissue through reduction of the disulfide bridge between the chains. O bese patients showed higher transhydrogenase activity (per U tissue protein wt, per U tissue wt, and in the total adipose tissue mass) than the lean group. There is a significant correlation between the activity per U tissue wt, and protein and total activity in the whole adipose tissue with respect to body mass index, with a higher activity in obese patients. The potential ofinsulin cleavage by adipose tissue in obese patients was a mean 5.6-fold higher than that in controla. The coexistence of high insulinemia and high cleavage capability implies that insulin secretion and turnover are increased in the o bese. Thus, white adipose tissue may be crucial in the control of energy availability through modulation ofinsulin cleavage. |
| publishDate |
1995 |
| dc.date.none.fl_str_mv |
1995 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/22382 |
| url |
https://hdl.handle.net/2445/22382 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: http://dx.doi.org/10.1210/jc.80.2.693 Journal of Clinical Endocrinology and Metabolism, 1995, vol. 80, p. 693-695 http://dx.doi.org/10.1210/jc.80.2.693 |
| dc.rights.none.fl_str_mv |
(c) The Endocrine Society, 1995 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) The Endocrine Society, 1995 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
The Endocrine Society |
| publisher.none.fl_str_mv |
The Endocrine Society |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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|
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|
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1869422896762322944 |
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15.301603 |