GLP-1 Receptor Agonists in Diabetic Kidney Disease

Diabetic kidney disease (DKD) is one of the most common complications in type 2 diabetes mellitus (T2D) and a major cause of morbidity and mortality in diabetes. Despite the widespread use of nephroprotective treatment of T2D, the incidence of DKD is increasing, and it is expected to become the fift...

Descripción completa

Detalles Bibliográficos
Autores: Rojano-Toimil, Alba|||0000-0002-2446-1827, Ciudin, Andreea|||0000-0001-5622-0203
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:304440
Acceso en línea:https://ddd.uab.cat/record/304440
https://dx.doi.org/urn:doi:10.3390/jcm10173955
Access Level:acceso abierto
Palabra clave:Diabetic kidney disease
GLP-1 receptor agonists
id ES_e7dfe6271f0defa5ca7d46c250064e49
oai_identifier_str oai:ddd.uab.cat:304440
network_acronym_str ES
network_name_str España
repository_id_str
spelling GLP-1 Receptor Agonists in Diabetic Kidney DiseaseFrom Physiology to Clinical OutcomesRojano-Toimil, Alba|||0000-0002-2446-1827Ciudin, Andreea|||0000-0001-5622-0203Diabetic kidney diseaseGLP-1 receptor agonistsDiabetic kidney disease (DKD) is one of the most common complications in type 2 diabetes mellitus (T2D) and a major cause of morbidity and mortality in diabetes. Despite the widespread use of nephroprotective treatment of T2D, the incidence of DKD is increasing, and it is expected to become the fifth cause of death worldwide within 20 years. Previous studies have demonstrated that GLP-1 receptor agonists (GLP-1 RA) have improved macrovascular and microvascular outcomes independent of glycemic differences, including DKD. GLP-1Ras' improvement on kidney physiology is mediated by natriuresis, reduction in hyperfiltration and renin-angiotensin-aldosterone system (RAAS) activity and anti-inflammatory properties. These findings translate into improved clinical outcomes such as an enhanced urine albumin-to-creatinine ratio (UACR) and a reduction in renal impairment and the need for renal replacement therapies (RRT). In this article, we review the role of GLP-1RAs on the mechanisms and effect in DKD and their clinical efficacy. 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/304440https://dx.doi.org/urn:doi:10.3390/jcm10173955reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3044402026-06-06T12:50:31Z
dc.title.none.fl_str_mv GLP-1 Receptor Agonists in Diabetic Kidney Disease
From Physiology to Clinical Outcomes
title GLP-1 Receptor Agonists in Diabetic Kidney Disease
spellingShingle GLP-1 Receptor Agonists in Diabetic Kidney Disease
Rojano-Toimil, Alba|||0000-0002-2446-1827
Diabetic kidney disease
GLP-1 receptor agonists
title_short GLP-1 Receptor Agonists in Diabetic Kidney Disease
title_full GLP-1 Receptor Agonists in Diabetic Kidney Disease
title_fullStr GLP-1 Receptor Agonists in Diabetic Kidney Disease
title_full_unstemmed GLP-1 Receptor Agonists in Diabetic Kidney Disease
title_sort GLP-1 Receptor Agonists in Diabetic Kidney Disease
dc.creator.none.fl_str_mv Rojano-Toimil, Alba|||0000-0002-2446-1827
Ciudin, Andreea|||0000-0001-5622-0203
author Rojano-Toimil, Alba|||0000-0002-2446-1827
author_facet Rojano-Toimil, Alba|||0000-0002-2446-1827
Ciudin, Andreea|||0000-0001-5622-0203
author_role author
author2 Ciudin, Andreea|||0000-0001-5622-0203
author2_role author
dc.subject.none.fl_str_mv Diabetic kidney disease
GLP-1 receptor agonists
topic Diabetic kidney disease
GLP-1 receptor agonists
description Diabetic kidney disease (DKD) is one of the most common complications in type 2 diabetes mellitus (T2D) and a major cause of morbidity and mortality in diabetes. Despite the widespread use of nephroprotective treatment of T2D, the incidence of DKD is increasing, and it is expected to become the fifth cause of death worldwide within 20 years. Previous studies have demonstrated that GLP-1 receptor agonists (GLP-1 RA) have improved macrovascular and microvascular outcomes independent of glycemic differences, including DKD. GLP-1Ras' improvement on kidney physiology is mediated by natriuresis, reduction in hyperfiltration and renin-angiotensin-aldosterone system (RAAS) activity and anti-inflammatory properties. These findings translate into improved clinical outcomes such as an enhanced urine albumin-to-creatinine ratio (UACR) and a reduction in renal impairment and the need for renal replacement therapies (RRT). In this article, we review the role of GLP-1RAs on the mechanisms and effect in DKD and their clinical efficacy.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/304440
https://dx.doi.org/urn:doi:10.3390/jcm10173955
url https://ddd.uab.cat/record/304440
https://dx.doi.org/urn:doi:10.3390/jcm10173955
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869422892813385729
score 15,811543

Similares en LA Referencia