Prostaglandin E2 and T cells: friends or foes?

Our understanding of the key players involved in the differential regulation of T-cell responses during inflammation, infection and auto-immunity is fundamental for designing efficient therapeutic strategies against immune diseases. With respect to this, the inhibitory role of the lipid mediator pro...

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Detalles Bibliográficos
Autores: Sreeramkumar, Vinatha, Fresno, Manuel, Cuesta Rubio, Natalia
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/113634
Acceso en línea:https://hdl.handle.net/20.500.14352/113634
Access Level:acceso abierto
Palabra clave:612.017
611.081.1
PGE2
EP receptors
immunosuppression
pro-inflammatory role
EP receptor antagonism
T cells
Inmunología
Biología celular (Biología)
Biología molecular (Biología)
2407 Biología Celular
2412 Inmunología
2415 Biología Molecular
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oai_identifier_str oai:docta.ucm.es:20.500.14352/113634
network_acronym_str ES
network_name_str España
repository_id_str
spelling Prostaglandin E2 and T cells: friends or foes?Sreeramkumar, VinathaFresno, ManuelCuesta Rubio, Natalia612.017611.081.1PGE2EP receptorsimmunosuppressionpro-inflammatory roleEP receptor antagonismT cellsInmunologíaBiología celular (Biología)Biología molecular (Biología)2407 Biología Celular2412 Inmunología2415 Biología MolecularOur understanding of the key players involved in the differential regulation of T-cell responses during inflammation, infection and auto-immunity is fundamental for designing efficient therapeutic strategies against immune diseases. With respect to this, the inhibitory role of the lipid mediator prostaglandin E2 (PGE2) in T-cell immunity has been documented since the 1970s. Studies that ensued investigating the underlying mechanisms substantiated the suppressive function of micromolar concentrations of PGE2 in T-cell activation, proliferation, differentiation and migration. However, the past decade has seen a revolution in this perspective, since nanomolar concentrations of PGE2 have been shown to potentiate Th1 and Th17 responses and aid in T-cell proliferation. The understanding of concentration-specific effects of PGE2 in other cell types, the development of mice deficient in each subtype of the PGE2 receptors (EP receptors) and the delineation of signalling pathways mediated by the EP receptors have enhanced our understanding of PGE2 as an immune-stimulator. PGE2 regulates a multitude of functions in T-cell activation and differentiation and these effects vary depending on the micro-environment of the cell, maturation and activation state of the cell, type of EP receptor involved, local concentration of PGE2 and whether it is a homeostatic or inflammatory scenario. In this review, we compartmentalize the various aspects of this complex relationship of PGE2 with T lymphocytes. Given the importance of this molecule in T-cell activation, we also address the possibility of using EP receptor antagonism as a potential therapeutic approach for some immune disorders.WileyUniversidad Complutense de Madrid20112011-09-2720112011-09-27journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/113634reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1136342026-06-02T12:44:21Z
dc.title.none.fl_str_mv Prostaglandin E2 and T cells: friends or foes?
title Prostaglandin E2 and T cells: friends or foes?
spellingShingle Prostaglandin E2 and T cells: friends or foes?
Sreeramkumar, Vinatha
612.017
611.081.1
PGE2
EP receptors
immunosuppression
pro-inflammatory role
EP receptor antagonism
T cells
Inmunología
Biología celular (Biología)
Biología molecular (Biología)
2407 Biología Celular
2412 Inmunología
2415 Biología Molecular
title_short Prostaglandin E2 and T cells: friends or foes?
title_full Prostaglandin E2 and T cells: friends or foes?
title_fullStr Prostaglandin E2 and T cells: friends or foes?
title_full_unstemmed Prostaglandin E2 and T cells: friends or foes?
title_sort Prostaglandin E2 and T cells: friends or foes?
dc.creator.none.fl_str_mv Sreeramkumar, Vinatha
Fresno, Manuel
Cuesta Rubio, Natalia
author Sreeramkumar, Vinatha
author_facet Sreeramkumar, Vinatha
Fresno, Manuel
Cuesta Rubio, Natalia
author_role author
author2 Fresno, Manuel
Cuesta Rubio, Natalia
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 612.017
611.081.1
PGE2
EP receptors
immunosuppression
pro-inflammatory role
EP receptor antagonism
T cells
Inmunología
Biología celular (Biología)
Biología molecular (Biología)
2407 Biología Celular
2412 Inmunología
2415 Biología Molecular
topic 612.017
611.081.1
PGE2
EP receptors
immunosuppression
pro-inflammatory role
EP receptor antagonism
T cells
Inmunología
Biología celular (Biología)
Biología molecular (Biología)
2407 Biología Celular
2412 Inmunología
2415 Biología Molecular
description Our understanding of the key players involved in the differential regulation of T-cell responses during inflammation, infection and auto-immunity is fundamental for designing efficient therapeutic strategies against immune diseases. With respect to this, the inhibitory role of the lipid mediator prostaglandin E2 (PGE2) in T-cell immunity has been documented since the 1970s. Studies that ensued investigating the underlying mechanisms substantiated the suppressive function of micromolar concentrations of PGE2 in T-cell activation, proliferation, differentiation and migration. However, the past decade has seen a revolution in this perspective, since nanomolar concentrations of PGE2 have been shown to potentiate Th1 and Th17 responses and aid in T-cell proliferation. The understanding of concentration-specific effects of PGE2 in other cell types, the development of mice deficient in each subtype of the PGE2 receptors (EP receptors) and the delineation of signalling pathways mediated by the EP receptors have enhanced our understanding of PGE2 as an immune-stimulator. PGE2 regulates a multitude of functions in T-cell activation and differentiation and these effects vary depending on the micro-environment of the cell, maturation and activation state of the cell, type of EP receptor involved, local concentration of PGE2 and whether it is a homeostatic or inflammatory scenario. In this review, we compartmentalize the various aspects of this complex relationship of PGE2 with T lymphocytes. Given the importance of this molecule in T-cell activation, we also address the possibility of using EP receptor antagonism as a potential therapeutic approach for some immune disorders.
publishDate 2011
dc.date.none.fl_str_mv 2011
2011-09-27
2011
2011-09-27
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/113634
url https://hdl.handle.net/20.500.14352/113634
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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