Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?

The aim of this study was to assess the association between alcohol intake and premature mortality (younger than 65 years) and to explore the effect of potential alcohol underreporting by heavy drinkers. We followed-up 20 272 university graduates. Four categories of alcohol intake were considered (a...

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Autores: Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7, Barbería-Latasa, M. (María)|||/items/81f3a714-5abc-4498-b03c-34167f75d908, Pérez-de-Rojas, J. (Javier)|||/items/9e84104e-0836-4549-a58d-7549c49ee6d1, Domínguez-Rodriguez, L.J. (Ligia Juliana)|||/items/00779463-fbeb-41b1-ba10-0d2ab64506e5, Gea, A. (Alfredo)|||/items/0fc6850b-e4e0-4795-960d-db184cd1385f
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/64588
Acceso en línea:https://hdl.handle.net/10171/64588
Access Level:acceso abierto
Palabra clave:Underreporting
Misclassification bias
Alcohol
FFQ
Mortality
Prospective studies
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spelling Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7Barbería-Latasa, M. (María)|||/items/81f3a714-5abc-4498-b03c-34167f75d908Pérez-de-Rojas, J. (Javier)|||/items/9e84104e-0836-4549-a58d-7549c49ee6d1Domínguez-Rodriguez, L.J. (Ligia Juliana)|||/items/00779463-fbeb-41b1-ba10-0d2ab64506e5Gea, A. (Alfredo)|||/items/0fc6850b-e4e0-4795-960d-db184cd1385fUnderreportingMisclassification biasAlcoholFFQMortalityProspective studiesThe aim of this study was to assess the association between alcohol intake and premature mortality (younger than 65 years) and to explore the effect of potential alcohol underreporting by heavy drinkers. We followed-up 20 272 university graduates. Four categories of alcohol intake were considered (abstainer, light, moderate and heavy consumption). Repeated measurements of alcohol intake and updated information on confounders were used in time-dependent Cox models. Potential underreporting of alcohol intake by some heavy drinkers (likely misclassified as light or moderate drinkers) was explicitly addressed in an attempt to correct potential underreporting by using indirect information. During 12·3 years of median follow-up (interquartile range: 6·8–15·0), 226 participants died before their 65th birthday. A higher risk of early mortality was found for the highest category of alcohol intake (≥50 g/d) in comparison with abstention (multivariable-adjusted hazard ratio (HR) = 2·82, 95 % CI 1·38, 5·79). In analyses of alcohol as a continuous variable, the multivariable-adjusted HR was 1·17 (95 % CI 1·08, 1·26), for each 10 g/d of alcohol. This harmful linear association was present both in uncorrected models and in models corrected for potential underreporting. No significant inverse association between light or moderate alcohol intake and premature mortality was observed, even after correcting for potential misclassification. Alcohol intake exhibited a harmful linear dose–response association with premature mortality (<65 years) in this young and highly educated Mediterranean cohort. Our attempts to correct for potential misclassification did not substantially change these results.Cambridge University PressDadun. Depósito Académico Digital Universidad de Navarra20222022-11-0420222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/64588reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/645882026-06-21T12:47:57Z
dc.title.none.fl_str_mv Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?
title Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?
spellingShingle Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?
Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Underreporting
Misclassification bias
Alcohol
FFQ
Mortality
Prospective studies
title_short Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?
title_full Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?
title_fullStr Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?
title_full_unstemmed Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?
title_sort Alcohol and early mortality (before 65 years) in the ‘seguimiento Universidad de Navarra’ (SUN) cohort: does any level reduce mortality?
dc.creator.none.fl_str_mv Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Barbería-Latasa, M. (María)|||/items/81f3a714-5abc-4498-b03c-34167f75d908
Pérez-de-Rojas, J. (Javier)|||/items/9e84104e-0836-4549-a58d-7549c49ee6d1
Domínguez-Rodriguez, L.J. (Ligia Juliana)|||/items/00779463-fbeb-41b1-ba10-0d2ab64506e5
Gea, A. (Alfredo)|||/items/0fc6850b-e4e0-4795-960d-db184cd1385f
author Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
author_facet Martínez-González, M.A. (Miguel Ángel)|||/items/8b591471-4165-4697-8534-cfa0ad5eb1b7
Barbería-Latasa, M. (María)|||/items/81f3a714-5abc-4498-b03c-34167f75d908
Pérez-de-Rojas, J. (Javier)|||/items/9e84104e-0836-4549-a58d-7549c49ee6d1
Domínguez-Rodriguez, L.J. (Ligia Juliana)|||/items/00779463-fbeb-41b1-ba10-0d2ab64506e5
Gea, A. (Alfredo)|||/items/0fc6850b-e4e0-4795-960d-db184cd1385f
author_role author
author2 Barbería-Latasa, M. (María)|||/items/81f3a714-5abc-4498-b03c-34167f75d908
Pérez-de-Rojas, J. (Javier)|||/items/9e84104e-0836-4549-a58d-7549c49ee6d1
Domínguez-Rodriguez, L.J. (Ligia Juliana)|||/items/00779463-fbeb-41b1-ba10-0d2ab64506e5
Gea, A. (Alfredo)|||/items/0fc6850b-e4e0-4795-960d-db184cd1385f
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Underreporting
Misclassification bias
Alcohol
FFQ
Mortality
Prospective studies
topic Underreporting
Misclassification bias
Alcohol
FFQ
Mortality
Prospective studies
description The aim of this study was to assess the association between alcohol intake and premature mortality (younger than 65 years) and to explore the effect of potential alcohol underreporting by heavy drinkers. We followed-up 20 272 university graduates. Four categories of alcohol intake were considered (abstainer, light, moderate and heavy consumption). Repeated measurements of alcohol intake and updated information on confounders were used in time-dependent Cox models. Potential underreporting of alcohol intake by some heavy drinkers (likely misclassified as light or moderate drinkers) was explicitly addressed in an attempt to correct potential underreporting by using indirect information. During 12·3 years of median follow-up (interquartile range: 6·8–15·0), 226 participants died before their 65th birthday. A higher risk of early mortality was found for the highest category of alcohol intake (≥50 g/d) in comparison with abstention (multivariable-adjusted hazard ratio (HR) = 2·82, 95 % CI 1·38, 5·79). In analyses of alcohol as a continuous variable, the multivariable-adjusted HR was 1·17 (95 % CI 1·08, 1·26), for each 10 g/d of alcohol. This harmful linear association was present both in uncorrected models and in models corrected for potential underreporting. No significant inverse association between light or moderate alcohol intake and premature mortality was observed, even after correcting for potential misclassification. Alcohol intake exhibited a harmful linear dose–response association with premature mortality (<65 years) in this young and highly educated Mediterranean cohort. Our attempts to correct for potential misclassification did not substantially change these results.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-11-04
2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/64588
url https://hdl.handle.net/10171/64588
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
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