Supporting information: Oligostyrylbenzene derivatives as potent G-quadruplex ligands with antiparasitic and antibacterial activity
Figure S1: Results of the FRET-Melting Assay at 1 μM ligand concentration; Figure S2: UV-Vis spectra of ligand (A) 1, (B) 2, (C) 3 and (D) 4 titrated with mit9438-K+ at the concentrations shown in the figure; Figure S3: UV-Vis spectra of ligand (A) 1, (B) 2, (C) 3 and (D) 4 titrated with SA5-K+ at t...
| Autores: | , , , , , , |
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| Tipo de recurso: | conjunto de datos |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/384667 |
| Acceso en línea: | http://hdl.handle.net/10261/384667 |
| Access Level: | acceso abierto |
| Palabra clave: | DNA G-quadruplex Ligands Photophysical properties Antiparasitic Antibiotic |
| Sumario: | Figure S1: Results of the FRET-Melting Assay at 1 μM ligand concentration; Figure S2: UV-Vis spectra of ligand (A) 1, (B) 2, (C) 3 and (D) 4 titrated with mit9438-K+ at the concentrations shown in the figure; Figure S3: UV-Vis spectra of ligand (A) 1, (B) 2, (C) 3 and (D) 4 titrated with SA5-K+ at the concentrations shown in the figure; Figure S4: UV-Vis spectra of ligand (A) 1, (B) 2, (C) 3 and (D) 4 titrated with EBR1-K+ at the concentrations shown in the figure; Figure S5: UV-Vis spectra of ligand (A) 1, (B) 2, (C) 3 and (D) 4 titrated with ds26-K+ at the concentrations shown in the figure; Figure S6: UV-Vis binding isotherm for the association between ligand (A) 1, (B) 2, (C) 4 and mit9438, SA5, EBR1 and ds26 following the change in ligand absorbance at (A) 350 nm, (B) 410 nm and (C) 450 nm; Figure S7: Results of cell uptake exhibited by compounds 1–4 at 1 µM for 15, 30 and 60 min at room temperature on (A) A. baumannii and (B) S.aureus; Table S1: Results of the FRET-Melting Assay carried out with ligands 1–4 at 5 µM; Tabla S2: Synergistic combinations for S.aureus. |
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