Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study

<p><span style="color:rgb( 46 , 46 , 46 )">The present study attempted for the first time to explore the effects of the daily oral intake of a phenolics-rich extract from chestnut shells (CS) on the metabolomic profiling of rat tissues by liquid chromatography coupled to Orbitr...

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Autores: Pinto, Diana, López-Yerena, Anallely, Almeida, Andreida, Sarmento, Bruno, Lamuela Raventós, Rosa Ma., Vallverdú i Queralt, Anna, Delerue-Matos, Cristina, Rodrigues, Francesca
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/208112
Acceso en línea:https://hdl.handle.net/2445/208112
Access Level:acceso abierto
Palabra clave:Metabolòmica
Marcadors bioquímics
Metabolomics
Biochemical markers
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spelling Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo studyPinto, DianaLópez-Yerena, AnallelyAlmeida, AndreidaSarmento, BrunoLamuela Raventós, Rosa Ma.Vallverdú i Queralt, AnnaDelerue-Matos, CristinaRodrigues, FrancescaMetabolòmicaMarcadors bioquímicsMetabolomicsBiochemical markers<p><span style="color:rgb( 46 , 46 , 46 )">The present study attempted for the first time to explore the effects of the daily oral intake of a phenolics-rich extract from chestnut shells (CS) on the metabolomic profiling of rat tissues by liquid chromatography coupled to Orbitrap-mass spectrometry (LC-ESI-LTQ-Orbitrap-MS) targeted to polyphenolics and their metabolites and screen potential oxidative stress biomarkers, validating its use as a promising nutraceutical ingredient with outstanding antioxidant properties for the prevention and co-therapy of lifestyle-related diseases triggered by oxidative stress. The results demonstrated new insights into the metabolomic fingerprinting of polyphenols from CS, confirming their absorption and biotransformation by phase I (hydrogenation) and II (glucuronidation, methylation, and sulfation) enzymes. Phenolic acids were the main polyphenolic class, followed by hydrolyzable tannins, flavanols, and lignans. In contrast to the liver, sulfated conjugates were the principal metabolites reaching the kidneys. The multivariate data analysis predicted an exceptional contribution of polyphenols and their microbial and phase II metabolites to the in-vivo antioxidant response of the CS extract in rats, recommending its use as an appealing source of anti-aging molecules for nutraceuticals. This is the first study that explored the relation between metabolomic profiling of rat tissues and in-vivo antioxidant effects after oral treatment with a phenolics-rich CS extract. © 2023 The Author(s)</span></p>Elsevier B.V.2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/208112Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.foodres.2023.112963Food Research International, 2023, vol. 170https://doi.org/10.1016/j.foodres.2023.112963cc-by-nc-nd (c) Diana Pinto, et al., 2023http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2081122026-05-27T06:46:51Z
dc.title.none.fl_str_mv Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study
title Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study
spellingShingle Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study
Pinto, Diana
Metabolòmica
Marcadors bioquímics
Metabolomics
Biochemical markers
title_short Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study
title_full Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study
title_fullStr Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study
title_full_unstemmed Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study
title_sort Metabolomic insights into phenolics-rich chestnut shells extract as a nutraceutical ingredient – A comprehensive evaluation of its impacts on oxidative stress biomarkers by an in-vivo study
dc.creator.none.fl_str_mv Pinto, Diana
López-Yerena, Anallely
Almeida, Andreida
Sarmento, Bruno
Lamuela Raventós, Rosa Ma.
Vallverdú i Queralt, Anna
Delerue-Matos, Cristina
Rodrigues, Francesca
author Pinto, Diana
author_facet Pinto, Diana
López-Yerena, Anallely
Almeida, Andreida
Sarmento, Bruno
Lamuela Raventós, Rosa Ma.
Vallverdú i Queralt, Anna
Delerue-Matos, Cristina
Rodrigues, Francesca
author_role author
author2 López-Yerena, Anallely
Almeida, Andreida
Sarmento, Bruno
Lamuela Raventós, Rosa Ma.
Vallverdú i Queralt, Anna
Delerue-Matos, Cristina
Rodrigues, Francesca
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Metabolòmica
Marcadors bioquímics
Metabolomics
Biochemical markers
topic Metabolòmica
Marcadors bioquímics
Metabolomics
Biochemical markers
description <p><span style="color:rgb( 46 , 46 , 46 )">The present study attempted for the first time to explore the effects of the daily oral intake of a phenolics-rich extract from chestnut shells (CS) on the metabolomic profiling of rat tissues by liquid chromatography coupled to Orbitrap-mass spectrometry (LC-ESI-LTQ-Orbitrap-MS) targeted to polyphenolics and their metabolites and screen potential oxidative stress biomarkers, validating its use as a promising nutraceutical ingredient with outstanding antioxidant properties for the prevention and co-therapy of lifestyle-related diseases triggered by oxidative stress. The results demonstrated new insights into the metabolomic fingerprinting of polyphenols from CS, confirming their absorption and biotransformation by phase I (hydrogenation) and II (glucuronidation, methylation, and sulfation) enzymes. Phenolic acids were the main polyphenolic class, followed by hydrolyzable tannins, flavanols, and lignans. In contrast to the liver, sulfated conjugates were the principal metabolites reaching the kidneys. The multivariate data analysis predicted an exceptional contribution of polyphenols and their microbial and phase II metabolites to the in-vivo antioxidant response of the CS extract in rats, recommending its use as an appealing source of anti-aging molecules for nutraceuticals. This is the first study that explored the relation between metabolomic profiling of rat tissues and in-vivo antioxidant effects after oral treatment with a phenolics-rich CS extract. © 2023 The Author(s)</span></p>
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/208112
url https://hdl.handle.net/2445/208112
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.foodres.2023.112963
Food Research International, 2023, vol. 170
https://doi.org/10.1016/j.foodres.2023.112963
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Diana Pinto, et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Diana Pinto, et al., 2023
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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