The use of high-intensity focused ultrasound for the rewarming of cryopreserved biological material
High-intensity focused ultrasound (HIFU) has been used in differentmedical applications in the last years. In this work, we present for the first time the use of HIFU in the field of cryopreservation, the preservation of biological material at low temperatures. An HIFU system has been designed with...
| Autores: | , , , |
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| Tipo de documento: | artigo |
| Estado: | Versión aceptada para publicación |
| Data de publicação: | 2021 |
| País: | España |
| Recursos: | Universidad de Sevilla (US) |
| Repositório: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/167005 |
| Acesso em linha: | https://hdl.handle.net/11441/167005 https://doi.org/10.1109/TUFFC.2020.3016950 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Cryopreservation FEM simulations Heat transfer High-intensity focused ultrasound (HIFU) |
| Resumo: | High-intensity focused ultrasound (HIFU) has been used in differentmedical applications in the last years. In this work, we present for the first time the use of HIFU in the field of cryopreservation, the preservation of biological material at low temperatures. An HIFU system has been designed with the objective of achieving a fast and uniform rewarming in organs, key to overcome the critical problem of devitrification. The finite-element simulations have been carried out using COMSOL Multiphysics software. An array of 26 ultrasonic transducers was simulated, achieving an HIFU focal area in the order of magnitude of a model organ (ovary). A parametric study of the warming rate and temperature gradients, as a function of the frequency and power of ultrasonicwaves,was performed.An optimal value for these parameters was found. The results validate the appropriateness of the technique,which is of utmost importance for the future creation of cryopreserved organ banks. |
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