Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)

BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. ME...

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Autores: Pedersen, Marie, Mendez, Michelle A., Espinosa, Ana, Villanueva Belmonte, Cristina, Gracia Lavedan, Esther, Sunyer Deu, Jordi, Nieuwenhuijsen, Mark J., Cirach, Marta, Agramunt, Silvia, Kogevinas, Manolis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/26174
Acceso en línea:http://hdl.handle.net/10230/26174
http://dx.doi.org/10.1289/ehp.1408613
Access Level:acceso abierto
Palabra clave:ADN
Embaràs -- Aspectes nutricionals
Contaminació
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spelling Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)Pedersen, MarieMendez, Michelle A.Espinosa, AnaVillanueva Belmonte, CristinaGracia Lavedan, EstherSunyer Deu, JordiNieuwenhuijsen, Mark J.Cirach, MartaAgramunt, SilviaKogevinas, ManolisADNEmbaràs -- Aspectes nutricionalsContaminacióBACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. METHODS: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the 32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population. RESULTS: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England. CONCLUSION: These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.The NewGeneris (FOOD-CT-2005-016320), ESCAPE (FP7-2007-211250), and HiWATE (FOOD-CT-2006-036224) studies were all funded by the European Union. M.P. holds a Juan de la Cierva postdoctoral fellowship awarded from the Spanish Ministry of Science and Innovation (JCI-2011-09479).National Institute of Environmental Health Sciences201620162015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/26174http://dx.doi.org/10.1289/ehp.1408613reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésEnvironmental health perspectives. 2015;123(4):374-80info:eu-repo/grantAgreement/EC/FP6/16320info:eu-repo/grantAgreement/EC/FP6/36224info:eu-repo/grantAgreement/EC/FP7/211250Reproduced with permission from Environmental Health Perspectives http://dx.doi.org/10.1289/ehp.1408613info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/261742026-06-12T07:21:37Z
dc.title.none.fl_str_mv Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
title Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
spellingShingle Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
Pedersen, Marie
ADN
Embaràs -- Aspectes nutricionals
Contaminació
title_short Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
title_full Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
title_fullStr Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
title_full_unstemmed Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
title_sort Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris)
dc.creator.none.fl_str_mv Pedersen, Marie
Mendez, Michelle A.
Espinosa, Ana
Villanueva Belmonte, Cristina
Gracia Lavedan, Esther
Sunyer Deu, Jordi
Nieuwenhuijsen, Mark J.
Cirach, Marta
Agramunt, Silvia
Kogevinas, Manolis
author Pedersen, Marie
author_facet Pedersen, Marie
Mendez, Michelle A.
Espinosa, Ana
Villanueva Belmonte, Cristina
Gracia Lavedan, Esther
Sunyer Deu, Jordi
Nieuwenhuijsen, Mark J.
Cirach, Marta
Agramunt, Silvia
Kogevinas, Manolis
author_role author
author2 Mendez, Michelle A.
Espinosa, Ana
Villanueva Belmonte, Cristina
Gracia Lavedan, Esther
Sunyer Deu, Jordi
Nieuwenhuijsen, Mark J.
Cirach, Marta
Agramunt, Silvia
Kogevinas, Manolis
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADN
Embaràs -- Aspectes nutricionals
Contaminació
topic ADN
Embaràs -- Aspectes nutricionals
Contaminació
description BACKGROUND: Bulky DNA adducts reflect genotoxic exposures, have been associated with lower birth weight, and may predict cancer risk. OBJECTIVE: We selected factors known or hypothesized to affect in utero adduct formation and repair and examined their associations with adduct levels in neonates. METHODS: Pregnant women from Greece, Spain, England, Denmark, and Norway were recruited in 2006-2010. Cord blood bulky DNA adduct levels were measured by the 32P-postlabeling technique (n = 511). Diet and maternal characteristics were assessed via questionnaires. Modeled exposures to air pollutants and drinking-water disinfection by-products, mainly trihalomethanes (THMs), were available for a large proportion of the study population. RESULTS: Greek and Spanish neonates had higher adduct levels than the northern European neonates [median, 12.1 (n = 179) vs. 6.8 (n = 332) adducts per 108 nucleotides, p < 0.001]. Residence in southern European countries, higher maternal body mass index, delivery by cesarean section, male infant sex, low maternal intake of fruits rich in vitamin C, high intake of dairy products, and low adherence to healthy diet score were statistically significantly associated with higher adduct levels in adjusted models. Exposure to fine particulate matter and nitrogen dioxide was associated with significantly higher adducts in the Danish subsample only. Overall, the pooled results for THMs in water show no evidence of association with adduct levels; however, there are country-specific differences in results with a suggestion of an association in England. CONCLUSION: These findings suggest that a combination of factors, including unknown country-specific factors, influence the bulky DNA adduct levels in neonates.
publishDate 2015
dc.date.none.fl_str_mv 2015
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/26174
http://dx.doi.org/10.1289/ehp.1408613
url http://hdl.handle.net/10230/26174
http://dx.doi.org/10.1289/ehp.1408613
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Environmental health perspectives. 2015;123(4):374-80
info:eu-repo/grantAgreement/EC/FP6/16320
info:eu-repo/grantAgreement/EC/FP6/36224
info:eu-repo/grantAgreement/EC/FP7/211250
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv National Institute of Environmental Health Sciences
publisher.none.fl_str_mv National Institute of Environmental Health Sciences
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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