Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer

The role of telomeres and telomerase in colorectal cancer (CRC) is well established as the major driving force in generating chromosomal instability. However, their potential as prognostic markers remains unclear. We investigated the outcome implications of telomeres and telomerase in this tumour ty...

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Autores: Fernández-Marcelo, Tamara, Sánchez Pernaute, Andrés, Pascua, Irene, Juan Chocano, María Del Carmen De, Head, Jacqueline, Torres García, Antonio José, Iniesta Serrano, María Pilar
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/93253
Acceso en línea:https://hdl.handle.net/20.500.14352/93253
Access Level:acceso abierto
Palabra clave:616-006.04
Ciencias Biomédicas
24 Ciencias de la Vida
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spelling Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal CancerFernández-Marcelo, TamaraSánchez Pernaute, AndrésPascua, IreneJuan Chocano, María Del Carmen DeHead, JacquelineTorres García, Antonio JoséIniesta Serrano, María Pilar616-006.04Ciencias Biomédicas24 Ciencias de la VidaThe role of telomeres and telomerase in colorectal cancer (CRC) is well established as the major driving force in generating chromosomal instability. However, their potential as prognostic markers remains unclear. We investigated the outcome implications of telomeres and telomerase in this tumour type. We considered telomere length (TL), ratio of telomere length in cancer to non-cancer tissue (T/N ratio), telomerase activity and TERT levels; their relation with clinical variables and their role as prognostic markers. We analyzed 132 CRCs and paired non-cancer tissues. Kaplan-Meier curves for disease-free survival were calculated for TL, T/N ratio, telomerase activity and TERT levels. Overall, tumours had shorter telomeres than non-tumour tissues (P < 0.001) and more than 80% of CRCs displayed telomerase activity. Telomere lengths of non-tumour tissues and CRCs were positively correlated (P < 0.001). Considering telomere status and clinical variables, the lowest degree of telomere shortening was shown by tumours located in the rectum (P = 0.021). Regarding prognosis studies, patients with tumours showing a mean TL < 6.35 Kb experienced a significantly better clinical evolution (P < 0.001) and none of them with the highest degree of tumour telomere shortening relapsed during the follow-up period (P = 0.043). The mean TL in CRCs emerged as an independent prognostic factor in the Cox analysis (P = 0.017). Telomerase-positive activity was identified as a marker that confers a trend toward a poor prognosis. In CRC, our results support the use of telomere status as an independent prognostic factor. Telomere status may contribute to explaining the different molecular identities of this tumour type.Public Library of ScienceMichel M OuelletteUniversidad Complutense de Madrid20162016-02-2520162016-02-25journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/93253reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/932532026-06-02T12:44:21Z
dc.title.none.fl_str_mv Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
title Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
spellingShingle Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
Fernández-Marcelo, Tamara
616-006.04
Ciencias Biomédicas
24 Ciencias de la Vida
title_short Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
title_full Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
title_fullStr Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
title_full_unstemmed Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
title_sort Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer
dc.creator.none.fl_str_mv Fernández-Marcelo, Tamara
Sánchez Pernaute, Andrés
Pascua, Irene
Juan Chocano, María Del Carmen De
Head, Jacqueline
Torres García, Antonio José
Iniesta Serrano, María Pilar
author Fernández-Marcelo, Tamara
author_facet Fernández-Marcelo, Tamara
Sánchez Pernaute, Andrés
Pascua, Irene
Juan Chocano, María Del Carmen De
Head, Jacqueline
Torres García, Antonio José
Iniesta Serrano, María Pilar
author_role author
author2 Sánchez Pernaute, Andrés
Pascua, Irene
Juan Chocano, María Del Carmen De
Head, Jacqueline
Torres García, Antonio José
Iniesta Serrano, María Pilar
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Michel M Ouellette
Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-006.04
Ciencias Biomédicas
24 Ciencias de la Vida
topic 616-006.04
Ciencias Biomédicas
24 Ciencias de la Vida
description The role of telomeres and telomerase in colorectal cancer (CRC) is well established as the major driving force in generating chromosomal instability. However, their potential as prognostic markers remains unclear. We investigated the outcome implications of telomeres and telomerase in this tumour type. We considered telomere length (TL), ratio of telomere length in cancer to non-cancer tissue (T/N ratio), telomerase activity and TERT levels; their relation with clinical variables and their role as prognostic markers. We analyzed 132 CRCs and paired non-cancer tissues. Kaplan-Meier curves for disease-free survival were calculated for TL, T/N ratio, telomerase activity and TERT levels. Overall, tumours had shorter telomeres than non-tumour tissues (P < 0.001) and more than 80% of CRCs displayed telomerase activity. Telomere lengths of non-tumour tissues and CRCs were positively correlated (P < 0.001). Considering telomere status and clinical variables, the lowest degree of telomere shortening was shown by tumours located in the rectum (P = 0.021). Regarding prognosis studies, patients with tumours showing a mean TL < 6.35 Kb experienced a significantly better clinical evolution (P < 0.001) and none of them with the highest degree of tumour telomere shortening relapsed during the follow-up period (P = 0.043). The mean TL in CRCs emerged as an independent prognostic factor in the Cox analysis (P = 0.017). Telomerase-positive activity was identified as a marker that confers a trend toward a poor prognosis. In CRC, our results support the use of telomere status as an independent prognostic factor. Telomere status may contribute to explaining the different molecular identities of this tumour type.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-02-25
2016
2016-02-25
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/93253
url https://hdl.handle.net/20.500.14352/93253
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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