Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study

Background The clinical and pathological features of primary melanoma are not sufficiently sensitive to accurately pre dict which patients are at a greater risk of relapse. Recently, a 31-gene expression profile (DecisionDx-Melanoma) test has shown promising results. Objectives To evaluate the early...

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Autores: Podlipnik, S, Carrera, C, Boada, A, Richarz, N, Lopez Estebaranz, JL, Pinedo Moraleda, F, Elosua Gonzalez, M, Martin Gonzalez, MM, Carrillo Gijon, R, Redondo, P, Moreno, E, Malvehy, J, Puig, S
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universidad Rey Juan Carlos
Repositorio:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
OAI Identifier:oai:burjcdigital.urjc.es:10115/29852
Acceso en línea:https://hdl.handle.net/10115/29852
Access Level:acceso abierto
Palabra clave:melanoma
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spelling Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort studyPodlipnik, SCarrera, CBoada, ARicharz, NLopez Estebaranz, JLPinedo Moraleda, FElosua Gonzalez, MMartin Gonzalez, MMCarrillo Gijon, RRedondo, PMoreno, EMalvehy, JPuig, SmelanomaBackground The clinical and pathological features of primary melanoma are not sufficiently sensitive to accurately pre dict which patients are at a greater risk of relapse. Recently, a 31-gene expression profile (DecisionDx-Melanoma) test has shown promising results. Objectives To evaluate the early prognostic performance of a genetic signature in a multicentre prospectively evalu ated cohort. Methods Inclusion of patients with AJCC stages IB and II conducted between April 2015 and December 2016. All patients were followed up prospectively to assess their risk of relapse. Prognostic performance of this test was evaluated individually and later combined with the AJCC staging system. Prognostic accuracy of disease-free survival was deter mined using Kaplan–Meier curves and Cox regression analysis. Results of the gene expression profile test were desig nated as Class 1 (low risk) and Class 2 (high risk). Results Median follow-up time was 26 months (IQR 22–30). The gene expression profile test was performed with 86 patients; seven had developed metastasis (8.1%) and all of them were in the Class 2 group, representing 21.2% of this group. Gene expression profile was an independent prognostic factor for relapse as indicated by multivariate Cox regression analysis, adjusted for AJCC stages and age. Conclusions This prospective multicentre cohort study, performed in a Spanish Caucasian cohort, shows that this 31- gene expression profile test could correctly identify patients at early AJCC stages who are at greater risk of relapse. We believe that gene expression profile in combination with the AJCC staging system could well improve the detection of patients who need intensive surveillance and optimize follow-up strategiesWiley202420242019info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10115/29852reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlosinstname:Universidad Rey Juan CarlosInglésAttribution-NonCommercial 4.0 Internationalhttps://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:burjcdigital.urjc.es:10115/298522026-06-24T12:48:17Z
dc.title.none.fl_str_mv Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study
title Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study
spellingShingle Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study
Podlipnik, S
melanoma
title_short Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study
title_full Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study
title_fullStr Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study
title_full_unstemmed Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study
title_sort Early outcome of a 31-gene expression profile test in 86 AJCC stage IB-II melanoma patients. A prospective multicentre cohort study
dc.creator.none.fl_str_mv Podlipnik, S
Carrera, C
Boada, A
Richarz, N
Lopez Estebaranz, JL
Pinedo Moraleda, F
Elosua Gonzalez, M
Martin Gonzalez, MM
Carrillo Gijon, R
Redondo, P
Moreno, E
Malvehy, J
Puig, S
author Podlipnik, S
author_facet Podlipnik, S
Carrera, C
Boada, A
Richarz, N
Lopez Estebaranz, JL
Pinedo Moraleda, F
Elosua Gonzalez, M
Martin Gonzalez, MM
Carrillo Gijon, R
Redondo, P
Moreno, E
Malvehy, J
Puig, S
author_role author
author2 Carrera, C
Boada, A
Richarz, N
Lopez Estebaranz, JL
Pinedo Moraleda, F
Elosua Gonzalez, M
Martin Gonzalez, MM
Carrillo Gijon, R
Redondo, P
Moreno, E
Malvehy, J
Puig, S
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv melanoma
topic melanoma
description Background The clinical and pathological features of primary melanoma are not sufficiently sensitive to accurately pre dict which patients are at a greater risk of relapse. Recently, a 31-gene expression profile (DecisionDx-Melanoma) test has shown promising results. Objectives To evaluate the early prognostic performance of a genetic signature in a multicentre prospectively evalu ated cohort. Methods Inclusion of patients with AJCC stages IB and II conducted between April 2015 and December 2016. All patients were followed up prospectively to assess their risk of relapse. Prognostic performance of this test was evaluated individually and later combined with the AJCC staging system. Prognostic accuracy of disease-free survival was deter mined using Kaplan–Meier curves and Cox regression analysis. Results of the gene expression profile test were desig nated as Class 1 (low risk) and Class 2 (high risk). Results Median follow-up time was 26 months (IQR 22–30). The gene expression profile test was performed with 86 patients; seven had developed metastasis (8.1%) and all of them were in the Class 2 group, representing 21.2% of this group. Gene expression profile was an independent prognostic factor for relapse as indicated by multivariate Cox regression analysis, adjusted for AJCC stages and age. Conclusions This prospective multicentre cohort study, performed in a Spanish Caucasian cohort, shows that this 31- gene expression profile test could correctly identify patients at early AJCC stages who are at greater risk of relapse. We believe that gene expression profile in combination with the AJCC staging system could well improve the detection of patients who need intensive surveillance and optimize follow-up strategies
publishDate 2019
dc.date.none.fl_str_mv 2019
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10115/29852
url https://hdl.handle.net/10115/29852
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv Attribution-NonCommercial 4.0 International
https://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial 4.0 International
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
instname:Universidad Rey Juan Carlos
instname_str Universidad Rey Juan Carlos
reponame_str BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
collection BURJC-Digital. Repositorio Institucional de la Universidad Rey Juan Carlos
repository.name.fl_str_mv
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