Circulating microRNAs as promising biomarkers in colorectal cancer

Colorectal cancer (CRC) is one of the most common cancers and a leading cause of cancer-related deaths worldwide. Despite numerous advances in therapeutic approaches, this cancer has a poor prognosis when it is diagnosed at late stages. Therefore, the scientific e ort is nowadays directed towards th...

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Detalhes bibliográficos
Autores: Rapado González, Óscar, Álvarez Castro, Ana, López López, Rafael, Iglesias Canle, José, Suárez Cunqueiro, María Mercedes, Muinelo Romay, Laura
Formato: artículo
Fecha de publicación:2019
País:España
Recursos:Universidad de Santiago de Compostela (USC)
Repositorio:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Idioma:inglés
OAI Identifier:oai:minerva.usc.gal:10347/21182
Acesso em linha:http://hdl.handle.net/10347/21182
Access Level:acceso abierto
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spelling Circulating microRNAs as promising biomarkers in colorectal cancerRapado González, ÓscarÁlvarez Castro, AnaLópez López, RafaelIglesias Canle, JoséSuárez Cunqueiro, María MercedesMuinelo Romay, LauraColorectal cancer (CRC) is one of the most common cancers and a leading cause of cancer-related deaths worldwide. Despite numerous advances in therapeutic approaches, this cancer has a poor prognosis when it is diagnosed at late stages. Therefore, the scientific e ort is nowadays directed towards the development of new non-invasive and dynamic biomarkers to improve the survival expectancy of CRC patients. In this sense, deregulated expression of many miRNAs has been shown to play an important role for CRC carcinogenesis and dissemination. Noticeably, an increasing number of studies highlight that circulating miRNAs, including those traveling inside exosomes or those released by tumor cells into circulation, constitute a promising tool for early detection, prognosis and therapy selection of CRC. Therefore, in this review we focus on the clinical potential of blood circulating miRNAs as emerging biomarkers with high value to improve the clinical management of CRC patients, providing a deep and complete perspective of the realities and challenges to translate these biomarkers to the clinical contextMDPIUniversidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-CirúrxicasUniversidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina20192019-01-0120192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10347/21182reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostelainstname:Universidad de Santiago de Compostela (USC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/)https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:minerva.usc.gal:10347/211822026-06-15T12:47:27Z
dc.title.none.fl_str_mv Circulating microRNAs as promising biomarkers in colorectal cancer
title Circulating microRNAs as promising biomarkers in colorectal cancer
spellingShingle Circulating microRNAs as promising biomarkers in colorectal cancer
Rapado González, Óscar
title_short Circulating microRNAs as promising biomarkers in colorectal cancer
title_full Circulating microRNAs as promising biomarkers in colorectal cancer
title_fullStr Circulating microRNAs as promising biomarkers in colorectal cancer
title_full_unstemmed Circulating microRNAs as promising biomarkers in colorectal cancer
title_sort Circulating microRNAs as promising biomarkers in colorectal cancer
dc.creator.none.fl_str_mv Rapado González, Óscar
Álvarez Castro, Ana
López López, Rafael
Iglesias Canle, José
Suárez Cunqueiro, María Mercedes
Muinelo Romay, Laura
author Rapado González, Óscar
author_facet Rapado González, Óscar
Álvarez Castro, Ana
López López, Rafael
Iglesias Canle, José
Suárez Cunqueiro, María Mercedes
Muinelo Romay, Laura
author_role author
author2 Álvarez Castro, Ana
López López, Rafael
Iglesias Canle, José
Suárez Cunqueiro, María Mercedes
Muinelo Romay, Laura
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de Santiago de Compostela. Departamento de Cirurxía e Especialidades Médico-Cirúrxicas
Universidade de Santiago de Compostela. Departamento de Psiquiatría, Radioloxía, Saúde Pública, Enfermaría e Medicina
description Colorectal cancer (CRC) is one of the most common cancers and a leading cause of cancer-related deaths worldwide. Despite numerous advances in therapeutic approaches, this cancer has a poor prognosis when it is diagnosed at late stages. Therefore, the scientific e ort is nowadays directed towards the development of new non-invasive and dynamic biomarkers to improve the survival expectancy of CRC patients. In this sense, deregulated expression of many miRNAs has been shown to play an important role for CRC carcinogenesis and dissemination. Noticeably, an increasing number of studies highlight that circulating miRNAs, including those traveling inside exosomes or those released by tumor cells into circulation, constitute a promising tool for early detection, prognosis and therapy selection of CRC. Therefore, in this review we focus on the clinical potential of blood circulating miRNAs as emerging biomarkers with high value to improve the clinical management of CRC patients, providing a deep and complete perspective of the realities and challenges to translate these biomarkers to the clinical context
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.none.fl_str_mv http://hdl.handle.net/10347/21182
url http://hdl.handle.net/10347/21182
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname:Universidad de Santiago de Compostela (USC)
instname_str Universidad de Santiago de Compostela (USC)
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
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