Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice

As populations increase their life expectancy, age-related neurodegenerative disorders such as Alzheimer's disease have become more common. I2-Imidazoline receptors (I2-IR) are widely distributed in the central nervous system, and dysregulation of I2-IR in patients with neurodegenerative diseas...

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Autores: Griñán Ferré, Christian, Vasilopoulou, Foteini, Abás Prades, Sònia, Rodríguez-Arévalo, Sergio, Bagan Polonio, Andrea, Sureda, Francesc X., Pérez, Belén, Callado, Luis F., García-Sevilla, Jesús A., García-Fuster, M. Julia, Escolano Mirón, Carmen, Pallàs i Llibería, Mercè, 1964-
Formato: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/140738
Acesso em linha:https://hdl.handle.net/2445/140738
Access Level:acceso abierto
Palavra-chave:Malaltia d'Alzheimer
Malalties neurodegeneratives
Envelliment
Alzheimer's disease
Neurodegenerative Diseases
Aging
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spelling Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 MiceGriñán Ferré, ChristianVasilopoulou, FoteiniAbás Prades, SòniaRodríguez-Arévalo, SergioBagan Polonio, AndreaSureda, Francesc X.Pérez, BelénCallado, Luis F.García-Sevilla, Jesús A.García-Fuster, M. JuliaEscolano Mirón, CarmenPallàs i Llibería, Mercè, 1964-Malaltia d'AlzheimerMalalties neurodegenerativesEnvellimentAlzheimer's diseaseNeurodegenerative DiseasesAgingAs populations increase their life expectancy, age-related neurodegenerative disorders such as Alzheimer's disease have become more common. I2-Imidazoline receptors (I2-IR) are widely distributed in the central nervous system, and dysregulation of I2-IR in patients with neurodegenerative diseases has been reported, suggesting their implication in cognitive impairment. This evidence indicates that high-affinity selective I2-IR ligands potentially contribute to the delay of neurodegeneration. In vivo studies in the female senescence accelerated mouse-prone 8 mice have shown that treatment with I2-IR ligands, MCR5 and MCR9, produce beneficial effects in behavior and cognition. Changes in molecular pathways implicated in oxidative stress, inflammation, synaptic plasticity, and apoptotic cell death were also studied. Furthermore, treatments with these I2-IR ligands diminished the amyloid precursor protein processing pathway and increased Aβ degrading enzymes in the hippocampus of SAMP8 mice. These results collectively demonstrate the neuroprotective role of these new I2-IR ligands in a mouse model of brain aging through specific pathways and suggest their potential as therapeutic agents in brain disorders and age-related neurodegenerative diseases. Keywords Imidazoline I2 receptors (2-imidazolin-4-yl)phosphonates Behavior Cognition Neurodegeneration Neuroprotection AgingSpringer Verlag2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/140738Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1007/s13311-018-00681-5Neurotherapeutics, 2018https://doi.org/10.1007/s13311-018-00681-5(c) American Society for Experimental NeuroTherapeutics, 2018info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1407382026-05-27T06:46:51Z
dc.title.none.fl_str_mv Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice
title Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice
spellingShingle Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice
Griñán Ferré, Christian
Malaltia d'Alzheimer
Malalties neurodegeneratives
Envelliment
Alzheimer's disease
Neurodegenerative Diseases
Aging
title_short Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice
title_full Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice
title_fullStr Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice
title_full_unstemmed Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice
title_sort Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice
dc.creator.none.fl_str_mv Griñán Ferré, Christian
Vasilopoulou, Foteini
Abás Prades, Sònia
Rodríguez-Arévalo, Sergio
Bagan Polonio, Andrea
Sureda, Francesc X.
Pérez, Belén
Callado, Luis F.
García-Sevilla, Jesús A.
García-Fuster, M. Julia
Escolano Mirón, Carmen
Pallàs i Llibería, Mercè, 1964-
author Griñán Ferré, Christian
author_facet Griñán Ferré, Christian
Vasilopoulou, Foteini
Abás Prades, Sònia
Rodríguez-Arévalo, Sergio
Bagan Polonio, Andrea
Sureda, Francesc X.
Pérez, Belén
Callado, Luis F.
García-Sevilla, Jesús A.
García-Fuster, M. Julia
Escolano Mirón, Carmen
Pallàs i Llibería, Mercè, 1964-
author_role author
author2 Vasilopoulou, Foteini
Abás Prades, Sònia
Rodríguez-Arévalo, Sergio
Bagan Polonio, Andrea
Sureda, Francesc X.
Pérez, Belén
Callado, Luis F.
García-Sevilla, Jesús A.
García-Fuster, M. Julia
Escolano Mirón, Carmen
Pallàs i Llibería, Mercè, 1964-
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Malalties neurodegeneratives
Envelliment
Alzheimer's disease
Neurodegenerative Diseases
Aging
topic Malaltia d'Alzheimer
Malalties neurodegeneratives
Envelliment
Alzheimer's disease
Neurodegenerative Diseases
Aging
description As populations increase their life expectancy, age-related neurodegenerative disorders such as Alzheimer's disease have become more common. I2-Imidazoline receptors (I2-IR) are widely distributed in the central nervous system, and dysregulation of I2-IR in patients with neurodegenerative diseases has been reported, suggesting their implication in cognitive impairment. This evidence indicates that high-affinity selective I2-IR ligands potentially contribute to the delay of neurodegeneration. In vivo studies in the female senescence accelerated mouse-prone 8 mice have shown that treatment with I2-IR ligands, MCR5 and MCR9, produce beneficial effects in behavior and cognition. Changes in molecular pathways implicated in oxidative stress, inflammation, synaptic plasticity, and apoptotic cell death were also studied. Furthermore, treatments with these I2-IR ligands diminished the amyloid precursor protein processing pathway and increased Aβ degrading enzymes in the hippocampus of SAMP8 mice. These results collectively demonstrate the neuroprotective role of these new I2-IR ligands in a mouse model of brain aging through specific pathways and suggest their potential as therapeutic agents in brain disorders and age-related neurodegenerative diseases. Keywords Imidazoline I2 receptors (2-imidazolin-4-yl)phosphonates Behavior Cognition Neurodegeneration Neuroprotection Aging
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/140738
url https://hdl.handle.net/2445/140738
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1007/s13311-018-00681-5
Neurotherapeutics, 2018
https://doi.org/10.1007/s13311-018-00681-5
dc.rights.none.fl_str_mv (c) American Society for Experimental NeuroTherapeutics, 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Society for Experimental NeuroTherapeutics, 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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