Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy

PurposeHematological parameters obtained from a pretreatment peripheral blood lab test, as well as indices calculated from these parameters, are associated with the prognosis of the disease in patients with head and neck squamous cell carcinomas (HNSCC). The aim of this study is to determine which o...

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Autores: Sansa, A, Vásquez, R, Valero, C, Vázquez, C, Holgado, A, Gayà, J, Rubio, D, León, X
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6478
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/6478
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004275740&doi=10.1007%2Fs12094-025-03897-y&partnerID=40&md5=78a5a8075a04c9100d2a0081759ef13a
Access Level:acceso abierto
Palabra clave:Biomarkers
Head and neck squamous cell carcinoma
Peripheral blood
Host
H-index
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spelling Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapySansa, AVásquez, RValero, CVázquez, CHolgado, AGayà, JRubio, DLeón, XBiomarkersHead and neck squamous cell carcinomaPeripheral bloodHostH-indexPurposeHematological parameters obtained from a pretreatment peripheral blood lab test, as well as indices calculated from these parameters, are associated with the prognosis of the disease in patients with head and neck squamous cell carcinomas (HNSCC). The aim of this study is to determine which of the parameters or indices would have the best prognostic ability in HNSCC patients treated with chemo-radiotherapy or bio-radiotherapy.Methods/patientsRetrospective study of 345 patients with HNSCC treated with chemo/bio-radiotherapy, for whom a pretreatment lab test was available.ResultsOf the parameters and indices analyzed, the one with the best prognostic capacity was the Host-index (H-index), which combines the prognostic capacity of hemoglobin and albumin levels, along with the absolute counts of neutrophils, monocytes, and lymphocytes. This index was available for 309 patients. Based on a recursive partitioning analysis, three groups of patients were defined according to the H-index. Considering as reference the patients with an H-index lower than 1.88 (n = 80, 25.9%), patients with an H-index value between 1.88 and 3.62 (n = 115, 37.2%) had a 2.74 times higher risk of dying due to the tumor (95% CI 1.41-5.30, P = 0.003), and patients with an H-index value greater than 3.62 (n = 114, 36.9%) had a 5.62 times higher risk (95% CI 2.95-10.81, P = 0.0001).ConclusionThe index derived from peripheral blood parameters that showed the best prognostic capacity in patients with head and neck squamous cell carcinoma treated with chemo/bio-radiotherapy was the H-index.SPRINGER INT PUBL AG2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/6478https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004275740&doi=10.1007%2Fs12094-025-03897-y&partnerID=40&md5=78a5a8075a04c9100d2a0081759ef13aClinical & Translational OncologyISSN: 1699048XISSNe: 16993055reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p64782026-06-21T15:30:37Z
dc.title.none.fl_str_mv Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy
title Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy
spellingShingle Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy
Sansa, A
Biomarkers
Head and neck squamous cell carcinoma
Peripheral blood
Host
H-index
title_short Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy
title_full Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy
title_fullStr Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy
title_full_unstemmed Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy
title_sort Prognostic value of pretreatment peripheral blood biomarkers in patients with head and neck squamous cell carcinoma treated with chemo/bioradiotherapy
dc.creator.none.fl_str_mv Sansa, A
Vásquez, R
Valero, C
Vázquez, C
Holgado, A
Gayà, J
Rubio, D
León, X
author Sansa, A
author_facet Sansa, A
Vásquez, R
Valero, C
Vázquez, C
Holgado, A
Gayà, J
Rubio, D
León, X
author_role author
author2 Vásquez, R
Valero, C
Vázquez, C
Holgado, A
Gayà, J
Rubio, D
León, X
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Biomarkers
Head and neck squamous cell carcinoma
Peripheral blood
Host
H-index
topic Biomarkers
Head and neck squamous cell carcinoma
Peripheral blood
Host
H-index
description PurposeHematological parameters obtained from a pretreatment peripheral blood lab test, as well as indices calculated from these parameters, are associated with the prognosis of the disease in patients with head and neck squamous cell carcinomas (HNSCC). The aim of this study is to determine which of the parameters or indices would have the best prognostic ability in HNSCC patients treated with chemo-radiotherapy or bio-radiotherapy.Methods/patientsRetrospective study of 345 patients with HNSCC treated with chemo/bio-radiotherapy, for whom a pretreatment lab test was available.ResultsOf the parameters and indices analyzed, the one with the best prognostic capacity was the Host-index (H-index), which combines the prognostic capacity of hemoglobin and albumin levels, along with the absolute counts of neutrophils, monocytes, and lymphocytes. This index was available for 309 patients. Based on a recursive partitioning analysis, three groups of patients were defined according to the H-index. Considering as reference the patients with an H-index lower than 1.88 (n = 80, 25.9%), patients with an H-index value between 1.88 and 3.62 (n = 115, 37.2%) had a 2.74 times higher risk of dying due to the tumor (95% CI 1.41-5.30, P = 0.003), and patients with an H-index value greater than 3.62 (n = 114, 36.9%) had a 5.62 times higher risk (95% CI 2.95-10.81, P = 0.0001).ConclusionThe index derived from peripheral blood parameters that showed the best prognostic capacity in patients with head and neck squamous cell carcinoma treated with chemo/bio-radiotherapy was the H-index.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/6478
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004275740&doi=10.1007%2Fs12094-025-03897-y&partnerID=40&md5=78a5a8075a04c9100d2a0081759ef13a
url https://i3pt.portalinvestigacion.com/publicaciones/6478
https://www.scopus.com/inward/record.uri?eid=2-s2.0-105004275740&doi=10.1007%2Fs12094-025-03897-y&partnerID=40&md5=78a5a8075a04c9100d2a0081759ef13a
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER INT PUBL AG
publisher.none.fl_str_mv SPRINGER INT PUBL AG
dc.source.none.fl_str_mv Clinical & Translational Oncology
ISSN: 1699048X
ISSNe: 16993055
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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