Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent

Apatitic bone cements have been used as a clinical bone substitutes and drug delivery vehicles for therapeutic agents in orthopedic applications. This has led to their combination with different drugs with known ability to foster bone formation. Recent studies have evaluated Simvastatin for its role...

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Autores: Khurana, Kanupriya, Guillem Martí, Jordi|||0000-0003-0307-2221, Mücklich, Frank T., Canal Barnils, Cristina|||0000-0002-3039-7462, Ginebra Molins, Maria Pau|||0000-0002-4700-5621
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/178147
Acceso en línea:https://hdl.handle.net/2117/178147
https://dx.doi.org/10.1002/jbm.b.34430
Access Level:acceso abierto
Palabra clave:Bone cements
Calcium phosphate
Tissue engineering
Controlled drug release
Endothelial progenitor cells
Mineralization
Rat mesenchymal stem cells
Vascularization
Ciments ossis
Fosfat de calci
Enginyeria de teixits
Àrees temàtiques de la UPC::Enginyeria dels materials
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oai_identifier_str oai:upcommons.upc.edu:2117/178147
network_acronym_str ES
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repository_id_str
spelling Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agentKhurana, KanupriyaGuillem Martí, Jordi|||0000-0003-0307-2221Mücklich, Frank T.Canal Barnils, Cristina|||0000-0002-3039-7462Ginebra Molins, Maria Pau|||0000-0002-4700-5621Bone cementsCalcium phosphateTissue engineeringControlled drug releaseEndothelial progenitor cellsMineralizationRat mesenchymal stem cellsVascularizationCiments ossisFosfat de calciEnginyeria de teixitsÀrees temàtiques de la UPC::Enginyeria dels materialsApatitic bone cements have been used as a clinical bone substitutes and drug delivery vehicles for therapeutic agents in orthopedic applications. This has led to their combination with different drugs with known ability to foster bone formation. Recent studies have evaluated Simvastatin for its role in enhanced bone regeneration, but its lipophilicity hampers incorporation and release to and from the bone graft. In this study, injectable calcium phosphate foams (i-CPF) based on a-tricalcium phosphate were loaded for the first time with Pitavastatin. The stability of the drug in different conditions relevant to this study, the effect of the drug on the i-CPFs properties, the release profile, and the in vitro biological performance with regard to mineralization and vascularization were investigated. Pitavastatin did not cause any changes in neither the micro nor the macro structure of the i-CPFs, which retained their biomimetic features. PITA-loaded i-CPFs showed a dose-dependent drug release, with early stage release kinetics clearly affected by the evolving microstructure due to the setting of cement. in vitro studies showed dose-dependent enhancement of mineralization and vascularization. Our findings contribute towards the design of controlled release with low drug dosing bone grafts: i-CPFs loaded with PITA as osteogenic and angiogenic agentPeer Reviewed20192019-01-0120202020-02-20journal articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/178147https://dx.doi.org/10.1002/jbm.b.34430reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivs 3.0 Spainhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/1781472026-05-27T15:37:01Z
dc.title.none.fl_str_mv Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent
title Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent
spellingShingle Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent
Khurana, Kanupriya
Bone cements
Calcium phosphate
Tissue engineering
Controlled drug release
Endothelial progenitor cells
Mineralization
Rat mesenchymal stem cells
Vascularization
Ciments ossis
Fosfat de calci
Enginyeria de teixits
Àrees temàtiques de la UPC::Enginyeria dels materials
title_short Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent
title_full Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent
title_fullStr Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent
title_full_unstemmed Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent
title_sort Injectable calcium phosphate foams for the delivery of Pitavastatin as osteogenic and angiogenic agent
dc.creator.none.fl_str_mv Khurana, Kanupriya
Guillem Martí, Jordi|||0000-0003-0307-2221
Mücklich, Frank T.
Canal Barnils, Cristina|||0000-0002-3039-7462
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
author Khurana, Kanupriya
author_facet Khurana, Kanupriya
Guillem Martí, Jordi|||0000-0003-0307-2221
Mücklich, Frank T.
Canal Barnils, Cristina|||0000-0002-3039-7462
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
author_role author
author2 Guillem Martí, Jordi|||0000-0003-0307-2221
Mücklich, Frank T.
Canal Barnils, Cristina|||0000-0002-3039-7462
Ginebra Molins, Maria Pau|||0000-0002-4700-5621
author2_role author
author
author
author
dc.subject.none.fl_str_mv Bone cements
Calcium phosphate
Tissue engineering
Controlled drug release
Endothelial progenitor cells
Mineralization
Rat mesenchymal stem cells
Vascularization
Ciments ossis
Fosfat de calci
Enginyeria de teixits
Àrees temàtiques de la UPC::Enginyeria dels materials
topic Bone cements
Calcium phosphate
Tissue engineering
Controlled drug release
Endothelial progenitor cells
Mineralization
Rat mesenchymal stem cells
Vascularization
Ciments ossis
Fosfat de calci
Enginyeria de teixits
Àrees temàtiques de la UPC::Enginyeria dels materials
description Apatitic bone cements have been used as a clinical bone substitutes and drug delivery vehicles for therapeutic agents in orthopedic applications. This has led to their combination with different drugs with known ability to foster bone formation. Recent studies have evaluated Simvastatin for its role in enhanced bone regeneration, but its lipophilicity hampers incorporation and release to and from the bone graft. In this study, injectable calcium phosphate foams (i-CPF) based on a-tricalcium phosphate were loaded for the first time with Pitavastatin. The stability of the drug in different conditions relevant to this study, the effect of the drug on the i-CPFs properties, the release profile, and the in vitro biological performance with regard to mineralization and vascularization were investigated. Pitavastatin did not cause any changes in neither the micro nor the macro structure of the i-CPFs, which retained their biomimetic features. PITA-loaded i-CPFs showed a dose-dependent drug release, with early stage release kinetics clearly affected by the evolving microstructure due to the setting of cement. in vitro studies showed dose-dependent enhancement of mineralization and vascularization. Our findings contribute towards the design of controlled release with low drug dosing bone grafts: i-CPFs loaded with PITA as osteogenic and angiogenic agent
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
2020
2020-02-20
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/178147
https://dx.doi.org/10.1002/jbm.b.34430
url https://hdl.handle.net/2117/178147
https://dx.doi.org/10.1002/jbm.b.34430
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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