Study of microfluidic production of polymer-based drug delivery vesicles
In this study of the microfluidic production of polymer-based drug delivery vehicles, first, the state of the art of this technique is presented, mentioning some recent developments in the field of microfluidics. It addresses the challenges faced in the development of new drugs and how microfluidics...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universitat Politècnica de Catalunya (UPC) |
| Repositorio: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglés |
| OAI Identifier: | oai:upcommons.upc.edu:2117/397702 |
| Acceso en línea: | https://hdl.handle.net/2117/397702 |
| Access Level: | acceso abierto |
| Palabra clave: | Microfluidic devices Drug delivery systems Microfluidic Devices Drug delivery Microfluidic production Drug delivery vesicles Dispositius microfluidics Medicaments -- Modes d'administració Àrees temàtiques de la UPC::Enginyeria mecànica::Mecànica de fluids |
| Sumario: | In this study of the microfluidic production of polymer-based drug delivery vehicles, first, the state of the art of this technique is presented, mentioning some recent developments in the field of microfluidics. It addresses the challenges faced in the development of new drugs and how microfluidics can contribute to mitigating them, providing real-life examples of application. Once the introductory part is completed, the principle of formation of these polymeric vesicles is defined, with emphasis on the structure of the polymer used in the practical part of this thesis and the flow-focusing technique used for the production of these vesicles. Additionally, the term encapsulation is introduced, indicating some advantages and disadvantages associated with it. Before defining the experiments in the experimental section, the technique used in this thesis in order to characterize the vesicles, known as Dynamic Light Scattering or DLS, is defined. It provides a general overview of this technology, as well as a mention of the advantages and limitations that this method has. Once completed, all the equipment and assembly necessary for the production of the polymeric vesicles are presented, providing detailed general information about each element. Subsequently, the substances used are described, followed by the definition of the different parts and tests that make up the practical part of this thesis. Finally, the obtained results are illustrated, and the conclusions drawn from this study are presented |
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