Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System

The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence...

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Detalles Bibliográficos
Autores: Fernández-García, Laura, Fernández-Cuenca, Felipe, Blasco, Lucía, López-Rojas, Rafael, Ambroa, Antón, López, María, Pascual, Álvaro, Bou, Germán, Tomás, María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/184549
Acceso en línea:http://hdl.handle.net/10261/184549
Access Level:acceso abierto
Palabra clave:Tolerance
Persistence
Chlorhexidine
Imipenem
Acinetobacter
Toxin-antitoxin
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spelling Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin SystemFernández-García, LauraFernández-Cuenca, FelipeBlasco, LucíaLópez-Rojas, RafaelAmbroa, AntónLópez, MaríaPascual, ÁlvaroBou, GermánTomás, MaríaTolerancePersistenceChlorhexidineImipenemAcinetobacterToxin-antitoxinThe molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.This study was funded by grants PI13/02390 and PI16/01163, awarded to M.T., and by grant PI11-02046, awarded to F.F.-C., within the State Plan for R+D+I 2013–2016 (National Plan for Scientific Research, Technological Development and Innovation 2008–2011) and cofinanced by the ISCIII-Deputy General Directorate of Evaluation and Promotion of Research—European Regional Development Fund “A Way of Making Europe” and the Instituto de Salud Carlos III FEDER, Spanish Network for the Research in Infectious Diseases (REIPI, grants RD12/0015/0010 and RD16/0016/0001), as well as by the Study Group on Mechanisms of Action and Resistance to Antimicrobials, GEMARA (SEIMC). M.T. was financially supported by the Miguel Servet Research Programme (SERGAS and ISCIII). L.F.-G. was financially supported by a predoctoral fellowship from the Xunta de Galicia (GAIN, Axencia de Innovación).Peer reviewedAmerican Society for MicrobiologyInstituto de Salud Carlos IIIEuropean CommissionMinisterio de Economía y Competitividad (España)Xunta de GaliciaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/184549reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1128/AAC.00250-18Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1845492026-05-22T06:33:51Z
dc.title.none.fl_str_mv Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
title Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
spellingShingle Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
Fernández-García, Laura
Tolerance
Persistence
Chlorhexidine
Imipenem
Acinetobacter
Toxin-antitoxin
title_short Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
title_full Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
title_fullStr Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
title_full_unstemmed Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
title_sort Relationship between Tolerance and Persistence Mechanisms in Acinetobacter baumannii Strains with AbkAB Toxin-Antitoxin System
dc.creator.none.fl_str_mv Fernández-García, Laura
Fernández-Cuenca, Felipe
Blasco, Lucía
López-Rojas, Rafael
Ambroa, Antón
López, María
Pascual, Álvaro
Bou, Germán
Tomás, María
author Fernández-García, Laura
author_facet Fernández-García, Laura
Fernández-Cuenca, Felipe
Blasco, Lucía
López-Rojas, Rafael
Ambroa, Antón
López, María
Pascual, Álvaro
Bou, Germán
Tomás, María
author_role author
author2 Fernández-Cuenca, Felipe
Blasco, Lucía
López-Rojas, Rafael
Ambroa, Antón
López, María
Pascual, Álvaro
Bou, Germán
Tomás, María
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
European Commission
Ministerio de Economía y Competitividad (España)
Xunta de Galicia
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Tolerance
Persistence
Chlorhexidine
Imipenem
Acinetobacter
Toxin-antitoxin
topic Tolerance
Persistence
Chlorhexidine
Imipenem
Acinetobacter
Toxin-antitoxin
description The molecular mechanisms of tolerance and persistence associated with several compounds in Acinetobacter baumannii clinical isolates are unknown. Using transcriptomic and phenotypic studies, we found a link between mechanisms of bacterial tolerance to chlorhexidine and the development of persistence in the presence of imipenem in an A. baumannii strain belonging to clinical clone ST-2 (OXA-24 β-lactamase and AbkAB toxin-antitoxin [TA] system carried in a plasmid). Interestingly, the strain A. baumannii ATCC 17978 (AbkAB TA system from plasmid) showed persistence in the presence of imipenem and chlorhexidine.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/184549
url http://hdl.handle.net/10261/184549
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1128/AAC.00250-18
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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