Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers

The arsenal against different types of cancers has increased impressively in the last decade. The detailed knowledge of the tumor microenvironment enables it to be manipulated in order to help the immune system fight against tumor cells by using specific checkpoint inhibitors, cell-based treatments,...

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Autores: Noguera-Ortega, Estela|||0000-0001-6507-0673, Guallar Garrido, Sandra|||0000-0002-9666-5757, Julián Gómez, Esther|||0000-0002-6558-3978
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:252740
Acceso en línea:https://ddd.uab.cat/record/252740
https://dx.doi.org/urn:doi:10.3390/cancers12071802
Access Level:acceso abierto
Palabra clave:BCG
Non-tuberculous mycobacteria
Adjuvant
Immunotherapy
Mycobacteria antigens
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spelling Mycobacteria-Based Vaccines as Immunotherapy for Non-urological CancersNoguera-Ortega, Estela|||0000-0001-6507-0673Guallar Garrido, Sandra|||0000-0002-9666-5757Julián Gómez, Esther|||0000-0002-6558-3978BCGNon-tuberculous mycobacteriaAdjuvantImmunotherapyMycobacteria antigensThe arsenal against different types of cancers has increased impressively in the last decade. The detailed knowledge of the tumor microenvironment enables it to be manipulated in order to help the immune system fight against tumor cells by using specific checkpoint inhibitors, cell-based treatments, targeted antibodies, and immune stimulants. In fact, it is widely known that the first immunotherapeutic tools as immune stimulants for cancer treatment were bacteria and still are; specifically, the use of Mycobacterium bovis bacillus Calmette-Guérin (BCG) continues to be the treatment of choice for preventing cancer recurrence and progression in non-invasive bladder cancer. BCG and also other mycobacteria or their components are currently under study for the immunotherapeutic treatment of different malignancies. This review focuses on the preclinical and clinical assays using mycobacteria to treat non-urological cancers, providing a wide knowledge of the beneficial applications of these microorganisms to manipulate the tumor microenvironment aiming at tumor clearance. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/252740https://dx.doi.org/urn:doi:10.3390/cancers12071802reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 RTI2018-098777-B-I00Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-229open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2527402026-06-06T12:50:31Z
dc.title.none.fl_str_mv Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers
title Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers
spellingShingle Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers
Noguera-Ortega, Estela|||0000-0001-6507-0673
BCG
Non-tuberculous mycobacteria
Adjuvant
Immunotherapy
Mycobacteria antigens
title_short Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers
title_full Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers
title_fullStr Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers
title_full_unstemmed Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers
title_sort Mycobacteria-Based Vaccines as Immunotherapy for Non-urological Cancers
dc.creator.none.fl_str_mv Noguera-Ortega, Estela|||0000-0001-6507-0673
Guallar Garrido, Sandra|||0000-0002-9666-5757
Julián Gómez, Esther|||0000-0002-6558-3978
author Noguera-Ortega, Estela|||0000-0001-6507-0673
author_facet Noguera-Ortega, Estela|||0000-0001-6507-0673
Guallar Garrido, Sandra|||0000-0002-9666-5757
Julián Gómez, Esther|||0000-0002-6558-3978
author_role author
author2 Guallar Garrido, Sandra|||0000-0002-9666-5757
Julián Gómez, Esther|||0000-0002-6558-3978
author2_role author
author
dc.subject.none.fl_str_mv BCG
Non-tuberculous mycobacteria
Adjuvant
Immunotherapy
Mycobacteria antigens
topic BCG
Non-tuberculous mycobacteria
Adjuvant
Immunotherapy
Mycobacteria antigens
description The arsenal against different types of cancers has increased impressively in the last decade. The detailed knowledge of the tumor microenvironment enables it to be manipulated in order to help the immune system fight against tumor cells by using specific checkpoint inhibitors, cell-based treatments, targeted antibodies, and immune stimulants. In fact, it is widely known that the first immunotherapeutic tools as immune stimulants for cancer treatment were bacteria and still are; specifically, the use of Mycobacterium bovis bacillus Calmette-Guérin (BCG) continues to be the treatment of choice for preventing cancer recurrence and progression in non-invasive bladder cancer. BCG and also other mycobacteria or their components are currently under study for the immunotherapeutic treatment of different malignancies. This review focuses on the preclinical and clinical assays using mycobacteria to treat non-urological cancers, providing a wide knowledge of the beneficial applications of these microorganisms to manipulate the tumor microenvironment aiming at tumor clearance.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/252740
https://dx.doi.org/urn:doi:10.3390/cancers12071802
url https://ddd.uab.cat/record/252740
https://dx.doi.org/urn:doi:10.3390/cancers12071802
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 RTI2018-098777-B-I00
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-229
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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