Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial
Background: physical exercise is an effective strategy for preserving functional capacity and improving the symptoms of frailty in older adults. In addition to functional gains, exercise is considered to be a cornerstone for enhancing cognitive function in frail older adults with cognitive impairmen...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Recursos: | Universidad Pública de Navarra |
| Repositorio: | Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
| OAI Identifier: | oai:academica-e.unavarra.es:2454/42665 |
| Acesso em linha: | https://hdl.handle.net/2454/42665 |
| Access Level: | acceso abierto |
| Palavra-chave: | Falls Frailty Functional capacity Multicomponent exercise programme |
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Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial |
| title |
Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial |
| spellingShingle |
Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial Casas Herrero, Álvaro Falls Frailty Functional capacity Multicomponent exercise programme |
| title_short |
Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial |
| title_full |
Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial |
| title_fullStr |
Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial |
| title_full_unstemmed |
Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial |
| title_sort |
Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trial |
| dc.creator.none.fl_str_mv |
Casas Herrero, Álvaro López Sáez de Asteasu, Mikel Antón Rodrigo, Iván Sánchez Sánchez, Juan Luis Montero Odasso, Manuel Marín Epelde, Itxaso Ramón Espinoza, Fernanda Zambom Ferraresi, Fabrício Petidier Torregrosa, Roberto Elexpuru Estomba, Jaione Álvarez Bustos, Alejandro Galbete Jiménez, Arkaitz Martínez Velilla, Nicolás Izquierdo Redín, Mikel |
| author |
Casas Herrero, Álvaro |
| author_facet |
Casas Herrero, Álvaro López Sáez de Asteasu, Mikel Antón Rodrigo, Iván Sánchez Sánchez, Juan Luis Montero Odasso, Manuel Marín Epelde, Itxaso Ramón Espinoza, Fernanda Zambom Ferraresi, Fabrício Petidier Torregrosa, Roberto Elexpuru Estomba, Jaione Álvarez Bustos, Alejandro Galbete Jiménez, Arkaitz Martínez Velilla, Nicolás Izquierdo Redín, Mikel |
| author_role |
author |
| author2 |
López Sáez de Asteasu, Mikel Antón Rodrigo, Iván Sánchez Sánchez, Juan Luis Montero Odasso, Manuel Marín Epelde, Itxaso Ramón Espinoza, Fernanda Zambom Ferraresi, Fabrício Petidier Torregrosa, Roberto Elexpuru Estomba, Jaione Álvarez Bustos, Alejandro Galbete Jiménez, Arkaitz Martínez Velilla, Nicolás Izquierdo Redín, Mikel |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Ciencias de la Salud Osasun Zientziak Gobierno de Navarra / Nafarroako Gobernua |
| dc.subject.none.fl_str_mv |
Falls Frailty Functional capacity Multicomponent exercise programme |
| topic |
Falls Frailty Functional capacity Multicomponent exercise programme |
| description |
Background: physical exercise is an effective strategy for preserving functional capacity and improving the symptoms of frailty in older adults. In addition to functional gains, exercise is considered to be a cornerstone for enhancing cognitive function in frail older adults with cognitive impairment and dementia. We assessed the effects of the Vivifrail exercise intervention for functional capacity, cognition, and well-being status in community-dwelling older adults. Methods: in a multicentre randomized controlled trial conducted in three tertiary hospitals in Spain, a total of 188 older patients with mild cognitive impairment or mild dementia (aged >75 years) were randomly assigned to an exercise intervention (n = 88) or a usual-care, control (n = 100) group. The intervention was based on the Vivifrail tailored multicomponent exercise programme, which included resistance, balance, flexibility (3 days/week), and gait-retraining exercises (5 days/week) and was performed for three consecutive months (http://vivifrail.com). The usual-care group received habitual outpatient care. The main endpoint was change in functional capacity from baseline to 1 and 3 months, assessed with the Short Physical Performance Battery (SPPB). Secondary endpoints were changes in cognitive function and handgrip strength after 1 and 3 months, and well-being status, falls, hospital admission rate, visits to the emergency department, and mortality after 3 months. Results: the Vivifrail exercise programme provided significant benefits in functional capacity over usual-care. The mean adherence to the exercise sessions was 79% in the first month and 68% in the following 2 months. The intervention group showed a mean increase (over the control group) of 0.86 points on the SPPB scale (95% confidence interval [CI] 0.32, 1.41 points; P < 0.01) after 1 month of intervention and 1.40 points (95% CI 0.82, 1.98 points; P < 0.001) after 3 months. Participants in the usual-care group showed no significant benefit in functional capacity (mean change of −0.17 points [95% CI −0.54, 0.19 points] after 1 month and −0.33 points [95% CI −0.70, 0.04 points] after 3 months), whereas the exercise intervention reversed this trend (0.69 points [95% CI 0.29, 1.09 points] after 1 month and 1.07 points [95% CI 0.63, 1.51 points] after 3 months). Exercise group also obtained significant benefits in cognitive function, muscle function, and depression after 3 months over control group (P < 0.05). No between-group differences were obtained in other secondary endpoints (P > 0.05). Conclusions: the Vivifrail exercise training programme is an effective and safe therapy for improving functional capacity in community-dwelling frail/prefrail older patients with mild cognitive impairment or mild dementia and also seems to have beneficial effect on cognition, muscle function, and mood status. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/2454/42665 |
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https://hdl.handle.net/2454/42665 |
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Inglés |
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Inglés |
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info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01814 |
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© 2022 The Authors. Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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© 2022 The Authors. Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International https://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/msword |
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Wiley Open Access |
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Wiley Open Access |
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reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra instname:Universidad Pública de Navarra |
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Universidad Pública de Navarra |
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Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
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Academica-e. Repositorio Institucional de la Universidad Pública de Navarra |
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1869422784321421312 |
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Effects of Vivifrail multicomponent intervention on functional capacity: a multicentre, randomized controlled trialCasas Herrero, ÁlvaroLópez Sáez de Asteasu, MikelAntón Rodrigo, IvánSánchez Sánchez, Juan LuisMontero Odasso, ManuelMarín Epelde, ItxasoRamón Espinoza, FernandaZambom Ferraresi, FabrícioPetidier Torregrosa, RobertoElexpuru Estomba, JaioneÁlvarez Bustos, AlejandroGalbete Jiménez, ArkaitzMartínez Velilla, NicolásIzquierdo Redín, MikelFallsFrailtyFunctional capacityMulticomponent exercise programmeBackground: physical exercise is an effective strategy for preserving functional capacity and improving the symptoms of frailty in older adults. In addition to functional gains, exercise is considered to be a cornerstone for enhancing cognitive function in frail older adults with cognitive impairment and dementia. We assessed the effects of the Vivifrail exercise intervention for functional capacity, cognition, and well-being status in community-dwelling older adults. Methods: in a multicentre randomized controlled trial conducted in three tertiary hospitals in Spain, a total of 188 older patients with mild cognitive impairment or mild dementia (aged >75 years) were randomly assigned to an exercise intervention (n = 88) or a usual-care, control (n = 100) group. The intervention was based on the Vivifrail tailored multicomponent exercise programme, which included resistance, balance, flexibility (3 days/week), and gait-retraining exercises (5 days/week) and was performed for three consecutive months (http://vivifrail.com). The usual-care group received habitual outpatient care. The main endpoint was change in functional capacity from baseline to 1 and 3 months, assessed with the Short Physical Performance Battery (SPPB). Secondary endpoints were changes in cognitive function and handgrip strength after 1 and 3 months, and well-being status, falls, hospital admission rate, visits to the emergency department, and mortality after 3 months. Results: the Vivifrail exercise programme provided significant benefits in functional capacity over usual-care. The mean adherence to the exercise sessions was 79% in the first month and 68% in the following 2 months. The intervention group showed a mean increase (over the control group) of 0.86 points on the SPPB scale (95% confidence interval [CI] 0.32, 1.41 points; P < 0.01) after 1 month of intervention and 1.40 points (95% CI 0.82, 1.98 points; P < 0.001) after 3 months. Participants in the usual-care group showed no significant benefit in functional capacity (mean change of −0.17 points [95% CI −0.54, 0.19 points] after 1 month and −0.33 points [95% CI −0.70, 0.04 points] after 3 months), whereas the exercise intervention reversed this trend (0.69 points [95% CI 0.29, 1.09 points] after 1 month and 1.07 points [95% CI 0.63, 1.51 points] after 3 months). Exercise group also obtained significant benefits in cognitive function, muscle function, and depression after 3 months over control group (P < 0.05). No between-group differences were obtained in other secondary endpoints (P > 0.05). Conclusions: the Vivifrail exercise training programme is an effective and safe therapy for improving functional capacity in community-dwelling frail/prefrail older patients with mild cognitive impairment or mild dementia and also seems to have beneficial effect on cognition, muscle function, and mood status.This study has been funded by a Gobierno de Navarra projectgrant and fondos FEDER (Resolución 426/2016, del 30 deseptiembre 28/16). Mikel Izquierdo is funded by a researchgrant PI17/01814 of the Ministerio de Economía, Industria yCompetitividad (ISCIII, FEDER).Wiley Open AccessCiencias de la SaludOsasun ZientziakGobierno de Navarra / Nafarroako Gobernua2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/mswordhttps://hdl.handle.net/2454/42665reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016 (ISCIII)/PI17%2F01814© 2022 The Authors. Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttps://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/426652026-06-17T12:41:47Z |
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15,812429 |