A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal Microbalance
[EN] Integrating acoustic wave sensors into lab-on-a-chip (LoC) devices is a well-known challenge. We address this challenge by designing a microfluidic device housing a monolithic array of 24 high-fundamental frequency quartz crystal microbalance with dissipation (HFF-QCMD) sensors. The device feat...
| Autores: | , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2020 |
| País: | España |
| Recursos: | Universitat Politècnica de València (UPV) |
| Repositório: | RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
| Idioma: | inglês |
| OAI Identifier: | oai:riunet.upv.es:10251/156021 |
| Acesso em linha: | https://riunet.upv.es/handle/10251/156021 |
| Access Level: | Acceso aberto |
| Palavra-chave: | HFF-QCM (high fundamental frequency quartz crystal microbalance) Mass transport Flow cell Biosensor Food safety PoC (point of care) MQCM (monolithic quartz crystal microbalance) TECNOLOGIA ELECTRONICA |
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oai:riunet.upv.es:10251/156021 |
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A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal MicrobalanceCalero-Alcarria, María Del SeñorGARCIA MOLLA, PABLOGarcía, MaríaGamero-Sandemetrio, EstherReviakine, IlyaFERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653García Narbón, José Vicente|||0000-0001-6303-8258Arnau Vives, Antonio|||0000-0002-5709-1690Jiménez Jiménez, Yolanda|||0000-0003-4835-9007HFF-QCM (high fundamental frequency quartz crystal microbalance)Mass transportFlow cellBiosensorFood safetyPoC (point of care)MQCM (monolithic quartz crystal microbalance)TECNOLOGIA ELECTRONICA[EN] Integrating acoustic wave sensors into lab-on-a-chip (LoC) devices is a well-known challenge. We address this challenge by designing a microfluidic device housing a monolithic array of 24 high-fundamental frequency quartz crystal microbalance with dissipation (HFF-QCMD) sensors. The device features six 6-µL channels of four sensors each for low-volume parallel measurements, a sealing mechanism that provides appropriate pressure control while assuring liquid confinement and maintaining good stability, and provides a mechanical, electrical, and thermal interface with the characterization electronics. We validate the device by measuring the response of the HFF-QCMD sensors to the air-to-liquid transition, for which the robust Kanazawa¿Gordon¿Mason theory exists, and then by studying the adsorption of model bioanalytes (neutravidin and biotinylated albumin). With these experiments, we show how the effects of the protein¿surface interactions propagate within adsorbed protein multilayers, offering essentially new insight into the design of affinity-based bioanalytical sensorsThis work was supported in part by Ministerio de Economía, Industria y Competitividad de España Agencia Estatal de Investigación with FEDER (Fondo Europeo de Desarrollo Regional) funds under Project AGL2016-77702-R and in part by the European Commission Horizon 2020 Programme, Capturing non-Amplified Tumor Circulating DA with Ultrasound Hidrodynamics, under Grant H2020-FETOPEN-2016-2017/737212-CATCH-U-DNA. M. Calero is the recipient of the doctoral fellowship BES-2017-080246 from the Ministerio de Economía, Industria y Competitividad de España.MDPI AGDepartamento de Ingeniería ElectrónicaEscuela Técnica Superior de Ingeniería de TelecomunicaciónEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialCentro de Investigación e Innovación en BioingenieríaAgencia Estatal de InvestigaciónEuropean Regional Development FundMinisterio de Economía y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20202020-11-24journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/156021reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengEuropean Commission https://doi.org/10.13039/501100000780 H2020 737212 Capturing non-Amplified Tumor Circulating DNA with Ultrasound HydrodynamicsMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 AGL2016-77702-R DISEÑO DE UN BIOSENSOR DE ADN BASADO EN TECNOLOGIA HFF-QCM PARA LA DETECCION DE SUSTANCIAS ADULTERANTES EN MIELAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 BES-2017-080246 DISEÑO DE UN BIOSENSOR DE ADN BASADO EN TECNOLOGIA HFF-QCM PARA LA DETECCION DE SUSTANCIAS ADULTERANTES EN MIELopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1560212026-06-13T07:49:27Z |
| dc.title.none.fl_str_mv |
A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal Microbalance |
| title |
A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal Microbalance |
| spellingShingle |
A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal Microbalance Calero-Alcarria, María Del Señor HFF-QCM (high fundamental frequency quartz crystal microbalance) Mass transport Flow cell Biosensor Food safety PoC (point of care) MQCM (monolithic quartz crystal microbalance) TECNOLOGIA ELECTRONICA |
| title_short |
A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal Microbalance |
| title_full |
A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal Microbalance |
| title_fullStr |
A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal Microbalance |
| title_full_unstemmed |
A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal Microbalance |
| title_sort |
A Multichannel Microfluidic Sensing Cartridge for Bioanalytical Applications of Monolithic Quartz Crystal Microbalance |
| dc.creator.none.fl_str_mv |
Calero-Alcarria, María Del Señor GARCIA MOLLA, PABLO García, María Gamero-Sandemetrio, Esther Reviakine, Ilya FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 García Narbón, José Vicente|||0000-0001-6303-8258 Arnau Vives, Antonio|||0000-0002-5709-1690 Jiménez Jiménez, Yolanda|||0000-0003-4835-9007 |
| author |
Calero-Alcarria, María Del Señor |
| author_facet |
Calero-Alcarria, María Del Señor GARCIA MOLLA, PABLO García, María Gamero-Sandemetrio, Esther Reviakine, Ilya FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 García Narbón, José Vicente|||0000-0001-6303-8258 Arnau Vives, Antonio|||0000-0002-5709-1690 Jiménez Jiménez, Yolanda|||0000-0003-4835-9007 |
| author_role |
author |
| author2 |
GARCIA MOLLA, PABLO García, María Gamero-Sandemetrio, Esther Reviakine, Ilya FERNÁNDEZ DÍAZ, ROMÁN|||0000-0002-8883-4653 García Narbón, José Vicente|||0000-0001-6303-8258 Arnau Vives, Antonio|||0000-0002-5709-1690 Jiménez Jiménez, Yolanda|||0000-0003-4835-9007 |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Departamento de Ingeniería Electrónica Escuela Técnica Superior de Ingeniería de Telecomunicación Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial Centro de Investigación e Innovación en Bioingeniería Agencia Estatal de Investigación European Regional Development Fund Ministerio de Economía y Competitividad Repositorio Institucional de la Universitat Politècnica de València Riunet |
| dc.subject.none.fl_str_mv |
HFF-QCM (high fundamental frequency quartz crystal microbalance) Mass transport Flow cell Biosensor Food safety PoC (point of care) MQCM (monolithic quartz crystal microbalance) TECNOLOGIA ELECTRONICA |
| topic |
HFF-QCM (high fundamental frequency quartz crystal microbalance) Mass transport Flow cell Biosensor Food safety PoC (point of care) MQCM (monolithic quartz crystal microbalance) TECNOLOGIA ELECTRONICA |
| description |
[EN] Integrating acoustic wave sensors into lab-on-a-chip (LoC) devices is a well-known challenge. We address this challenge by designing a microfluidic device housing a monolithic array of 24 high-fundamental frequency quartz crystal microbalance with dissipation (HFF-QCMD) sensors. The device features six 6-µL channels of four sensors each for low-volume parallel measurements, a sealing mechanism that provides appropriate pressure control while assuring liquid confinement and maintaining good stability, and provides a mechanical, electrical, and thermal interface with the characterization electronics. We validate the device by measuring the response of the HFF-QCMD sensors to the air-to-liquid transition, for which the robust Kanazawa¿Gordon¿Mason theory exists, and then by studying the adsorption of model bioanalytes (neutravidin and biotinylated albumin). With these experiments, we show how the effects of the protein¿surface interactions propagate within adsorbed protein multilayers, offering essentially new insight into the design of affinity-based bioanalytical sensors |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020 2020-11-24 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://riunet.upv.es/handle/10251/156021 |
| url |
https://riunet.upv.es/handle/10251/156021 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Commission https://doi.org/10.13039/501100000780 H2020 737212 Capturing non-Amplified Tumor Circulating DNA with Ultrasound Hydrodynamics Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 AGL2016-77702-R DISEÑO DE UN BIOSENSOR DE ADN BASADO EN TECNOLOGIA HFF-QCM PARA LA DETECCION DE SUSTANCIAS ADULTERANTES EN MIEL Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 BES-2017-080246 DISEÑO DE UN BIOSENSOR DE ADN BASADO EN TECNOLOGIA HFF-QCM PARA LA DETECCION DE SUSTANCIAS ADULTERANTES EN MIEL |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Reserva de todos los derechos http://rightsstatements.org/vocab/InC/1.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Reserva de todos los derechos http://rightsstatements.org/vocab/InC/1.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI AG |
| publisher.none.fl_str_mv |
MDPI AG |
| dc.source.none.fl_str_mv |
reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia instname:Universitat Politècnica de València (UPV) |
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Universitat Politècnica de València (UPV) |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia |
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1869422775922327552 |
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15,300724 |