Ovine TRIM5α can restrict visna/maedi virus

The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesi...

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Detalles Bibliográficos
Autores: Jauregui, Paula, Crespo Otano, Helena, Glaría Ezquer, Idoia, Luján, Lluís, Contreras, A., Rosati, Sergio, Andrés Cara, Damián de, Amorena Zabalza, Beatriz, Towers, G. J., Reina Arias, Ramsés
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/32035
Acceso en línea:https://hdl.handle.net/2454/32035
Access Level:acceso abierto
Palabra clave:TRIM5α
Visna/maedi virus
Sheep
Goats
Descripción
Sumario:The restrictive properties of tripartite motif-containing 5 alpha (TRIM5α) from small ruminant species have not been explored. Here, we identify highly similar TRIM5α sequences in sheep and goats. Cells transduced with ovine TRIM5α effectively restricted the lentivirus visna/maedi virus DNA synthesis. Proteasome inhibition in cells transduced with ovine TRIM5α restored restricted viral DNA synthesis, suggesting a conserved mechanism of restriction. Identification of TRIM5α active molecular species may open new prophylactic strategies against lentiviral infections.

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