Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas

p15(INK4b), p16(INK4a) and O(6)-methylguanine DNA methyltransferase (MGMT) gene hypermethylation was studied in 22 patients with primary cutaneous T-cell lymphomas (CTCL). p15(INK4b) and p16(INK4a) inactivation is present in early and advanced disease and seems to be independent of disease stage. MG...

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Detalles Bibliográficos
Autores: Gallardo, F. (Fernando), Esteller, Manel, Pujol, Ramon M., Costa, Carlota, Estrach Panella, Ma. Teresa (María Teresa), Servitje Bedate, Octavio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2004
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172734
Acceso en línea:https://hdl.handle.net/2445/172734
Access Level:acceso abierto
Palabra clave:Genètica
Limfomes
Cèl·lules T
Genetics
Lymphomas
T cells
Descripción
Sumario:p15(INK4b), p16(INK4a) and O(6)-methylguanine DNA methyltransferase (MGMT) gene hypermethylation was studied in 22 patients with primary cutaneous T-cell lymphomas (CTCL). p15(INK4b) and p16(INK4a) inactivation is present in early and advanced disease and seems to be independent of disease stage. MGMT inactivation may play a pathogenetic role in a subset of CTCL.

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