The analytical impact of extracellular vesicles PSA on different commercial total PSA measurement methods
Evaluation; Extracellular vesicles; Immunoassays
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:dnet:recercat____::fd5172ea8c4294ce21df7c1d4db691b5 |
| Acceso en línea: | http://hdl.handle.net/11351/14532 https://hdl.handle.net/11351/14532 |
| Access Level: | acceso abierto |
| Palabra clave: | Pròstata - Càncer - Diagnòstic Antigen prostàtic específic Immunoassaig DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms Other subheadings::Other subheadings::/diagnosis CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Serine Endopeptidases::Kallikreins::Prostate-Specific Antigen ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Immunologic Techniques::Immunoassay ANATOMY::Cells::Cellular Structures::Extracellular Space::Extracellular Vesicles ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata Otros calificadores::Otros calificadores::/diagnóstico COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::hidrolasas::péptido hidrolasas::endopeptidasas::serina endopeptidasas::calicreínas::antígeno prostático específico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas inmunológicas::inmunoanálisis ANATOMÍA::células::estructuras celulares::espacio extracelular::vesículas extracelulares |
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The analytical impact of extracellular vesicles PSA on different commercial total PSA measurement methods |
| title |
The analytical impact of extracellular vesicles PSA on different commercial total PSA measurement methods |
| spellingShingle |
The analytical impact of extracellular vesicles PSA on different commercial total PSA measurement methods Moreno, Ana Pròstata - Càncer - Diagnòstic Antigen prostàtic específic Immunoassaig DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms Other subheadings::Other subheadings::/diagnosis CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Serine Endopeptidases::Kallikreins::Prostate-Specific Antigen ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Immunologic Techniques::Immunoassay ANATOMY::Cells::Cellular Structures::Extracellular Space::Extracellular Vesicles ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata Otros calificadores::Otros calificadores::/diagnóstico COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::hidrolasas::péptido hidrolasas::endopeptidasas::serina endopeptidasas::calicreínas::antígeno prostático específico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas inmunológicas::inmunoanálisis ANATOMÍA::células::estructuras celulares::espacio extracelular::vesículas extracelulares |
| title_short |
The analytical impact of extracellular vesicles PSA on different commercial total PSA measurement methods |
| title_full |
The analytical impact of extracellular vesicles PSA on different commercial total PSA measurement methods |
| title_fullStr |
The analytical impact of extracellular vesicles PSA on different commercial total PSA measurement methods |
| title_full_unstemmed |
The analytical impact of extracellular vesicles PSA on different commercial total PSA measurement methods |
| title_sort |
The analytical impact of extracellular vesicles PSA on different commercial total PSA measurement methods |
| dc.creator.none.fl_str_mv |
Moreno, Ana Sandúa, Amaia Varo, Nerea Ancizu-Marckert, Javier Ferrer Costa, Roser Jacobs-Cacha, Conxita |
| author |
Moreno, Ana |
| author_facet |
Moreno, Ana Sandúa, Amaia Varo, Nerea Ancizu-Marckert, Javier Ferrer Costa, Roser Jacobs-Cacha, Conxita |
| author_role |
author |
| author2 |
Sandúa, Amaia Varo, Nerea Ancizu-Marckert, Javier Ferrer Costa, Roser Jacobs-Cacha, Conxita |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Institut Català de la Salut [Moreno A, Sandúa A] Service of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain. Laboratory of circulating biomarkers in cancer, Cancer Center Clínica Universidad de Navarra, Pamplona, Spain. [Ferrer-Costa R, Jacobs-Cacha C] Servei de Bioquímica Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Bioquímica Clínica, Vehiculització de Fàrmacs i Teràpia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Varo N] Service of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain. [Ancizu-Marckert J] Department of Urology, Clínica Universidad De Navarra, Pamplona, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Pròstata - Càncer - Diagnòstic Antigen prostàtic específic Immunoassaig DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms Other subheadings::Other subheadings::/diagnosis CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Serine Endopeptidases::Kallikreins::Prostate-Specific Antigen ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Immunologic Techniques::Immunoassay ANATOMY::Cells::Cellular Structures::Extracellular Space::Extracellular Vesicles ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata Otros calificadores::Otros calificadores::/diagnóstico COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::hidrolasas::péptido hidrolasas::endopeptidasas::serina endopeptidasas::calicreínas::antígeno prostático específico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas inmunológicas::inmunoanálisis ANATOMÍA::células::estructuras celulares::espacio extracelular::vesículas extracelulares |
| topic |
Pròstata - Càncer - Diagnòstic Antigen prostàtic específic Immunoassaig DISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic Neoplasms Other subheadings::Other subheadings::/diagnosis CHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Serine Endopeptidases::Kallikreins::Prostate-Specific Antigen ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Immunologic Techniques::Immunoassay ANATOMY::Cells::Cellular Structures::Extracellular Space::Extracellular Vesicles ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstata Otros calificadores::Otros calificadores::/diagnóstico COMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::hidrolasas::péptido hidrolasas::endopeptidasas::serina endopeptidasas::calicreínas::antígeno prostático específico TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas inmunológicas::inmunoanálisis ANATOMÍA::células::estructuras celulares::espacio extracelular::vesículas extracelulares |
| description |
Evaluation; Extracellular vesicles; Immunoassays |
| publishDate |
2026 |
| dc.date.none.fl_str_mv |
2026 2026 2026 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11351/14532 https://hdl.handle.net/11351/14532 |
| url |
http://hdl.handle.net/11351/14532 https://hdl.handle.net/11351/14532 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Biochemia Medica;36(1) https://doi.org/10.11613/BM.2026.010703 |
| dc.rights.none.fl_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Croatian Society of Medical Biochemistry and Laboratory Medicine |
| publisher.none.fl_str_mv |
Croatian Society of Medical Biochemistry and Laboratory Medicine |
| dc.source.none.fl_str_mv |
Scientia reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869422770817859584 |
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The analytical impact of extracellular vesicles PSA on different commercial total PSA measurement methodsMoreno, AnaSandúa, AmaiaVaro, NereaAncizu-Marckert, JavierFerrer Costa, RoserJacobs-Cacha, ConxitaPròstata - Càncer - DiagnòsticAntigen prostàtic específicImmunoassaigDISEASES::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Genital Neoplasms, Male::Prostatic NeoplasmsOther subheadings::Other subheadings::/diagnosisCHEMICALS AND DRUGS::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Endopeptidases::Serine Endopeptidases::Kallikreins::Prostate-Specific AntigenANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Immunologic Techniques::ImmunoassayANATOMY::Cells::Cellular Structures::Extracellular Space::Extracellular VesiclesENFERMEDADES::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias de los genitales masculinos::neoplasias de la próstataOtros calificadores::Otros calificadores::/diagnósticoCOMPUESTOS QUÍMICOS Y DROGAS::enzimas y coenzimas::enzimas::hidrolasas::péptido hidrolasas::endopeptidasas::serina endopeptidasas::calicreínas::antígeno prostático específicoTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas inmunológicas::inmunoanálisisANATOMÍA::células::estructuras celulares::espacio extracelular::vesículas extracelularesEvaluation; Extracellular vesicles; ImmunoassaysEvaluación; Vesículas extracelulares; InmunoensayosAvaluació; Vesícules extracel·lulars; ImmunoassajosIntroduction Prostate-specific antigen (PSA) can circulate bound to extracellular vesicles (EVs) and its measurement (ev-PSA) can be useful in prostate cancer. Although not designed with that purpose, total PSA assays react with ev-PSA. We evaluated the analytical performance of several total PSA assays in ev-PSA quantification and the impact of ev-PSA on total PSA measurement. Materials and methods Extracellular vesicles were isolated from 83 serum samples from prostate cancer patients by size exclusion chromatography or ultracentrifugation. PSA was quantified in serum, EVs, International Standard for PSA 17/100 from the World Health Organization (WHO IS 17/100) and exosomes from lymph node carcinoma of the prostate (LNCaP) cell line, using commercial immunoassays (Elecsys, Atellica, Immulite, Liaison and Kryptor). Results Nanoparticle tracking analysis showed that the WHO IS 17/100 contains significantly less EVs than serum (P < 0.001). The sensitivity to detect ev-PSA followed this order: Elecsys ~ Atellica > Immulite > Liaison > Kryptor. Ev-PSA could be detected in all serum samples with Elecsys and Atellica, but not with Immulite (87.8%), Liaison (58.5%) or Kryptor (48.8%). Bland-Altman analysis showed a proportional bias in ev-PSA quantification between Elecsys and other methods. Addition of ev-PSA to serum samples caused a proportional bias in PSA measurement between Elecsys and Immulite methods, with a relationship (r2 = 0.99; P < 0.001) between ev-PSA and the difference in total PSA concentration between both methods. Conclusions While ev-PSA can be measured using commercial kits, notable differences exist between methods, which could lead to potential discrepancies in serum total PSA results across various assays.Croatian Society of Medical Biochemistry and Laboratory MedicineInstitut Català de la Salut[Moreno A, Sandúa A] Service of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain. Laboratory of circulating biomarkers in cancer, Cancer Center Clínica Universidad de Navarra, Pamplona, Spain. [Ferrer-Costa R, Jacobs-Cacha C] Servei de Bioquímica Clínica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Grup de Recerca de Bioquímica Clínica, Vehiculització de Fàrmacs i Teràpia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Varo N] Service of Biochemistry, Clínica Universidad de Navarra, Pamplona, Spain. [Ancizu-Marckert J] Department of Urology, Clínica Universidad De Navarra, Pamplona, SpainVall d'Hebron Barcelona Hospital Campus202620262026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/11351/14532https://hdl.handle.net/11351/14532Scientiareponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésBiochemia Medica;36(1)https://doi.org/10.11613/BM.2026.010703Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:recercat____::fd5172ea8c4294ce21df7c1d4db691b52026-05-29T05:05:01Z |
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15,812429 |