High BDNF serum levels are associated to good cognitive functioning in bipolar disorder

Background: Neurotrophins such as brain-derived neurotrophic factor (BDNF), inflammation and oxidative damage may contribute to the pathophysiology of bipolar disorder (BD) in terms of illness activity. To date, there is a lack of studies linking the cognitive impairment observed in BD with these ne...

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Autores: Mora, Ester, Portella Moll, María Jesús, Piñol Ripoll, Gerard, López, Ricard, Cuadras, Daniel, Forcada, Irene, Teres, Montse, Vieta i Pascual, Eduard, 1963-, Mur, Maria
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2019
País:España
Recursos:Universidad de Barcelona
Repositório:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/178961
Acesso em linha:https://hdl.handle.net/2445/178961
Access Level:Acceso aberto
Palavra-chave:Trastorn bipolar
Manic-depressive illness
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spelling High BDNF serum levels are associated to good cognitive functioning in bipolar disorderMora, EsterPortella Moll, María JesúsPiñol Ripoll, GerardLópez, RicardCuadras, DanielForcada, IreneTeres, MontseVieta i Pascual, Eduard, 1963-Mur, MariaTrastorn bipolarManic-depressive illnessBackground: Neurotrophins such as brain-derived neurotrophic factor (BDNF), inflammation and oxidative damage may contribute to the pathophysiology of bipolar disorder (BD) in terms of illness activity. To date, there is a lack of studies linking the cognitive impairment observed in BD with these neurobiological mechanisms. This study aimed to investigate the role of these neurobiological factors in clinical and cognitive outcomes in a sample of bipolar individuals. Methods: We measured serum BDNF, cytokines and oxidative stress markers in a sample of 133 individuals: 52 euthymic bipolar patients, 32 manic patients and 49 healthy controls. They were all assessed with a comprehensive cognitive battery. Sociodemographic and clinical data were collected. Multiple linear regression models were built to study associations of neurotrophins and inflammatory and oxidative measures with cognitive functioning. Results: BDNF levels were decreased in euthymic (p = 0.039) and manic (p < 0.001) individuals. Conversely, inflammatory (interleukin 6 (IL-6)) (p = 0.019) and oxidative stress (p = 0.003) measures were increased in bipolar individuals compared to controls. BDNF levels were associated with executive functioning (β = 0.01, p = 0.02) and verbal memory (β = 0.013, p = 0.005), together with other demographic variables. In particular, verbal memory was also associated with obesity (β=-0.04, p = 0.005). Neither inflammatory markers, oxidative stress markers nor other relevant clinical variables showed any association with cognitive outcome. Conclusions: Of all the peripheral neurobiological factors analysed, BDNF was the only one significantly associated with cognitive dysfunction in bipolar disorder individuals. This study emphasizes the role of BDNF not only across mood phases but also in cognitive functioning.Cambridge University Press2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/178961Articles publicats en revistes (Medicina)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.eurpsy.2019.02.006European Psychiatry, 2019, vol. 60, p. 97-107https://doi.org/10.1016/j.eurpsy.2019.02.006(c) Elsevier Masson SAS, 2019info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1789612026-05-27T06:46:51Z
dc.title.none.fl_str_mv High BDNF serum levels are associated to good cognitive functioning in bipolar disorder
title High BDNF serum levels are associated to good cognitive functioning in bipolar disorder
spellingShingle High BDNF serum levels are associated to good cognitive functioning in bipolar disorder
Mora, Ester
Trastorn bipolar
Manic-depressive illness
title_short High BDNF serum levels are associated to good cognitive functioning in bipolar disorder
title_full High BDNF serum levels are associated to good cognitive functioning in bipolar disorder
title_fullStr High BDNF serum levels are associated to good cognitive functioning in bipolar disorder
title_full_unstemmed High BDNF serum levels are associated to good cognitive functioning in bipolar disorder
title_sort High BDNF serum levels are associated to good cognitive functioning in bipolar disorder
dc.creator.none.fl_str_mv Mora, Ester
Portella Moll, María Jesús
Piñol Ripoll, Gerard
López, Ricard
Cuadras, Daniel
Forcada, Irene
Teres, Montse
Vieta i Pascual, Eduard, 1963-
Mur, Maria
author Mora, Ester
author_facet Mora, Ester
Portella Moll, María Jesús
Piñol Ripoll, Gerard
López, Ricard
Cuadras, Daniel
Forcada, Irene
Teres, Montse
Vieta i Pascual, Eduard, 1963-
Mur, Maria
author_role author
author2 Portella Moll, María Jesús
Piñol Ripoll, Gerard
López, Ricard
Cuadras, Daniel
Forcada, Irene
Teres, Montse
Vieta i Pascual, Eduard, 1963-
Mur, Maria
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trastorn bipolar
Manic-depressive illness
topic Trastorn bipolar
Manic-depressive illness
description Background: Neurotrophins such as brain-derived neurotrophic factor (BDNF), inflammation and oxidative damage may contribute to the pathophysiology of bipolar disorder (BD) in terms of illness activity. To date, there is a lack of studies linking the cognitive impairment observed in BD with these neurobiological mechanisms. This study aimed to investigate the role of these neurobiological factors in clinical and cognitive outcomes in a sample of bipolar individuals. Methods: We measured serum BDNF, cytokines and oxidative stress markers in a sample of 133 individuals: 52 euthymic bipolar patients, 32 manic patients and 49 healthy controls. They were all assessed with a comprehensive cognitive battery. Sociodemographic and clinical data were collected. Multiple linear regression models were built to study associations of neurotrophins and inflammatory and oxidative measures with cognitive functioning. Results: BDNF levels were decreased in euthymic (p = 0.039) and manic (p < 0.001) individuals. Conversely, inflammatory (interleukin 6 (IL-6)) (p = 0.019) and oxidative stress (p = 0.003) measures were increased in bipolar individuals compared to controls. BDNF levels were associated with executive functioning (β = 0.01, p = 0.02) and verbal memory (β = 0.013, p = 0.005), together with other demographic variables. In particular, verbal memory was also associated with obesity (β=-0.04, p = 0.005). Neither inflammatory markers, oxidative stress markers nor other relevant clinical variables showed any association with cognitive outcome. Conclusions: Of all the peripheral neurobiological factors analysed, BDNF was the only one significantly associated with cognitive dysfunction in bipolar disorder individuals. This study emphasizes the role of BDNF not only across mood phases but also in cognitive functioning.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/178961
url https://hdl.handle.net/2445/178961
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.eurpsy.2019.02.006
European Psychiatry, 2019, vol. 60, p. 97-107
https://doi.org/10.1016/j.eurpsy.2019.02.006
dc.rights.none.fl_str_mv (c) Elsevier Masson SAS, 2019
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Elsevier Masson SAS, 2019
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Cambridge University Press
publisher.none.fl_str_mv Cambridge University Press
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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