Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study

Cardiovascular disease is linked to high serum low density lipoprotein (LDL)-cholesterol levels. Cardiovascular risk may be indirectly influenced by genetic load. Serum LDL-cholesterol levels may be reduced by the consumption of food enriched with plant sterols (PS). The aim was to test a plant ster...

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Authors: San Mauro Martín, Ismael, Garicano Vilar, Elena, Sanz Rojo, Sara, Collado Yurrita, Luis Rodolfo, Pérez Arruche, Eva, Arce Delgado, Esperanza, Blumenfeld Olivares, Javier Andrés
Format: article
Publication Date:2019
Country:España
Institution:Universidad Complutense de Madrid (UCM)
Repository:Docta Complutense
Language:English
OAI Identifier:oai:docta.ucm.es:20.500.14352/12584
Online Access:https://hdl.handle.net/20.500.14352/12584
Access Level:Open access
Keyword:children
cholesterol
genetics
low-density lipoprotein cholesterol
sterol
Cardiología
Microbiología médica
3205.01 Cardiología
3201.03 Microbiología Clínica
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spelling Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional StudySan Mauro Martín, IsmaelGaricano Vilar, ElenaSanz Rojo, SaraCollado Yurrita, Luis RodolfoPérez Arruche, EvaArce Delgado, EsperanzaBlumenfeld Olivares, Javier Andréschildrencholesterolgeneticslow-density lipoprotein cholesterolsterolCardiologíaMicrobiología médica3205.01 Cardiología3201.03 Microbiología ClínicaCardiovascular disease is linked to high serum low density lipoprotein (LDL)-cholesterol levels. Cardiovascular risk may be indirectly influenced by genetic load. Serum LDL-cholesterol levels may be reduced by the consumption of food enriched with plant sterols (PS). The aim was to test a plant sterol treatment on cholesterol levels according to different genetic polymorphisms. A pilot interventional trial was performed in 26 children (n = 16 girls, n = 10 boys). Seven hundred milliliters/day of commercial skimmed milk with added plant sterols delivering 2.2 g plant sterols were ingested for three weeks. Blood draws were performed at the baseline and end of the study. Significant modifications of non-high density lipoprotein (HDL)-cholesterol (p = 0.010; p = 0.013) and LDL-cholesterol (p = 0.004; p = 0.013) levels appeared in the genes LIPC C-514T and PPAR-α L162V carriers. No statistically significant differences were observed for other genes. LIPC C-514T and PPAR-alpha L162V carriers could benefit from a plant sterol supplement to ameliorate hypercholesterolemia.MDPIUniversidad Complutense de Madrid20192019-10-2120192019-10-21journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/12584reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/125842026-06-02T12:44:21Z
dc.title.none.fl_str_mv Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study
title Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study
spellingShingle Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study
San Mauro Martín, Ismael
children
cholesterol
genetics
low-density lipoprotein cholesterol
sterol
Cardiología
Microbiología médica
3205.01 Cardiología
3201.03 Microbiología Clínica
title_short Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study
title_full Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study
title_fullStr Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study
title_full_unstemmed Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study
title_sort Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study
dc.creator.none.fl_str_mv San Mauro Martín, Ismael
Garicano Vilar, Elena
Sanz Rojo, Sara
Collado Yurrita, Luis Rodolfo
Pérez Arruche, Eva
Arce Delgado, Esperanza
Blumenfeld Olivares, Javier Andrés
author San Mauro Martín, Ismael
author_facet San Mauro Martín, Ismael
Garicano Vilar, Elena
Sanz Rojo, Sara
Collado Yurrita, Luis Rodolfo
Pérez Arruche, Eva
Arce Delgado, Esperanza
Blumenfeld Olivares, Javier Andrés
author_role author
author2 Garicano Vilar, Elena
Sanz Rojo, Sara
Collado Yurrita, Luis Rodolfo
Pérez Arruche, Eva
Arce Delgado, Esperanza
Blumenfeld Olivares, Javier Andrés
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv children
cholesterol
genetics
low-density lipoprotein cholesterol
sterol
Cardiología
Microbiología médica
3205.01 Cardiología
3201.03 Microbiología Clínica
topic children
cholesterol
genetics
low-density lipoprotein cholesterol
sterol
Cardiología
Microbiología médica
3205.01 Cardiología
3201.03 Microbiología Clínica
description Cardiovascular disease is linked to high serum low density lipoprotein (LDL)-cholesterol levels. Cardiovascular risk may be indirectly influenced by genetic load. Serum LDL-cholesterol levels may be reduced by the consumption of food enriched with plant sterols (PS). The aim was to test a plant sterol treatment on cholesterol levels according to different genetic polymorphisms. A pilot interventional trial was performed in 26 children (n = 16 girls, n = 10 boys). Seven hundred milliliters/day of commercial skimmed milk with added plant sterols delivering 2.2 g plant sterols were ingested for three weeks. Blood draws were performed at the baseline and end of the study. Significant modifications of non-high density lipoprotein (HDL)-cholesterol (p = 0.010; p = 0.013) and LDL-cholesterol (p = 0.004; p = 0.013) levels appeared in the genes LIPC C-514T and PPAR-α L162V carriers. No statistically significant differences were observed for other genes. LIPC C-514T and PPAR-alpha L162V carriers could benefit from a plant sterol supplement to ameliorate hypercholesterolemia.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-10-21
2019
2019-10-21
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/12584
url https://hdl.handle.net/20.500.14352/12584
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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