Genomic response to selection for predatory behavior in a mammalian model of adaptive radiation

If genetic architectures of various quantitative traits are similar, as studies on model organisms suggest, comparable selection pressures should produce similar molecular patterns for various traits. To test this prediction, we used a laboratory model of vertebrate adaptive radiation to investigate...

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Autores: Konczal, Mateusz, Koteja, Pawel, Orloska-Feuer, Patrycja, Radwan, Jacek, Sadowska, Edyta T., Babik, Wieslaw
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2016
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/33127
Acceso en línea:http://hdl.handle.net/10230/33127
http://dx.doi.org/10.1093/molbev/msw121
Access Level:acceso abierto
Palabra clave:Adaptació (Fisiologia)
Múrids -- Genètica
Depredació (Biologia)
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spelling Genomic response to selection for predatory behavior in a mammalian model of adaptive radiationKonczal, MateuszKoteja, PawelOrloska-Feuer, PatrycjaRadwan, JacekSadowska, Edyta T.Babik, WieslawAdaptació (Fisiologia)Múrids -- GenèticaDepredació (Biologia)If genetic architectures of various quantitative traits are similar, as studies on model organisms suggest, comparable selection pressures should produce similar molecular patterns for various traits. To test this prediction, we used a laboratory model of vertebrate adaptive radiation to investigate the genetic basis of the response to selection for predatory behavior and compare it with evolution of aerobic capacity reported in an earlier work. After 13 generations of selection, the proportion of bank voles (Myodes [=Clethrionomys] glareolus) showing predatory behavior was five times higher in selected lines than in controls. We analyzed the hippocampus and liver transcriptomes and found repeatable changes in allele frequencies and gene expression. Genes with the largest differences between predatory and control lines are associated with hunger, aggression, biological rhythms, and functioning of the nervous system. Evolution of predatory behavior could be meaningfully compared with evolution of high aerobic capacity, because the experiments and analyses were performed in the same methodological framework. The number of genes that changed expression was much smaller in predatory lines, and allele frequencies changed repeatably in predatory but not in aerobic lines. This suggests that more variants of smaller effects underlie variation in aerobic performance, whereas fewer variants of larger effects underlie variation in predatory behavior. Our results thus contradict the view that comparable selection pressures for different quantitative traits produce similar molecular patterns. Therefore, to gain knowledge about molecular-level response to selection for complex traits, we need to investigate not only multiple replicate populations but also multiple quantitative traits.This work was supported by the Polish Ministry of Science and Higher Education (N N303 816740 to P.K.) and Jagiellonian University (DS/WBINOZ/INOS/757 to P.K. and DS/WBINOZ/INOS/762 to W.B.). M.K. acknowledges support of the Spanish Ministry of Economy and Competitiveness, “Centro de Excelencia Severo Ochoa 2013-2017”, SEV-2012-0208Oxford University Press201720172016info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/33127http://dx.doi.org/10.1093/molbev/msw121reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésMolecular Biology and Evolution. 2016 Sep;33(9):2429-40© Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Molecular Biology and Evolution following peer review. The definitive publisher-authenticated version Konczal M, Koteja P, Orlowska-Feuer P, Radwan J, Sadowska ET, Babik W. Genomic response to selection for predatory behavior in a mammalian model of adaptive radiation. Mol Biol Evol. 2016 Sep; 33(9): 2429-40 is available online at: http://dx.doi.org/10.1093/molbev/msw121info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/331272026-06-12T07:21:37Z
dc.title.none.fl_str_mv Genomic response to selection for predatory behavior in a mammalian model of adaptive radiation
title Genomic response to selection for predatory behavior in a mammalian model of adaptive radiation
spellingShingle Genomic response to selection for predatory behavior in a mammalian model of adaptive radiation
Konczal, Mateusz
Adaptació (Fisiologia)
Múrids -- Genètica
Depredació (Biologia)
title_short Genomic response to selection for predatory behavior in a mammalian model of adaptive radiation
title_full Genomic response to selection for predatory behavior in a mammalian model of adaptive radiation
title_fullStr Genomic response to selection for predatory behavior in a mammalian model of adaptive radiation
title_full_unstemmed Genomic response to selection for predatory behavior in a mammalian model of adaptive radiation
title_sort Genomic response to selection for predatory behavior in a mammalian model of adaptive radiation
dc.creator.none.fl_str_mv Konczal, Mateusz
Koteja, Pawel
Orloska-Feuer, Patrycja
Radwan, Jacek
Sadowska, Edyta T.
Babik, Wieslaw
author Konczal, Mateusz
author_facet Konczal, Mateusz
Koteja, Pawel
Orloska-Feuer, Patrycja
Radwan, Jacek
Sadowska, Edyta T.
Babik, Wieslaw
author_role author
author2 Koteja, Pawel
Orloska-Feuer, Patrycja
Radwan, Jacek
Sadowska, Edyta T.
Babik, Wieslaw
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Adaptació (Fisiologia)
Múrids -- Genètica
Depredació (Biologia)
topic Adaptació (Fisiologia)
Múrids -- Genètica
Depredació (Biologia)
description If genetic architectures of various quantitative traits are similar, as studies on model organisms suggest, comparable selection pressures should produce similar molecular patterns for various traits. To test this prediction, we used a laboratory model of vertebrate adaptive radiation to investigate the genetic basis of the response to selection for predatory behavior and compare it with evolution of aerobic capacity reported in an earlier work. After 13 generations of selection, the proportion of bank voles (Myodes [=Clethrionomys] glareolus) showing predatory behavior was five times higher in selected lines than in controls. We analyzed the hippocampus and liver transcriptomes and found repeatable changes in allele frequencies and gene expression. Genes with the largest differences between predatory and control lines are associated with hunger, aggression, biological rhythms, and functioning of the nervous system. Evolution of predatory behavior could be meaningfully compared with evolution of high aerobic capacity, because the experiments and analyses were performed in the same methodological framework. The number of genes that changed expression was much smaller in predatory lines, and allele frequencies changed repeatably in predatory but not in aerobic lines. This suggests that more variants of smaller effects underlie variation in aerobic performance, whereas fewer variants of larger effects underlie variation in predatory behavior. Our results thus contradict the view that comparable selection pressures for different quantitative traits produce similar molecular patterns. Therefore, to gain knowledge about molecular-level response to selection for complex traits, we need to investigate not only multiple replicate populations but also multiple quantitative traits.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/33127
http://dx.doi.org/10.1093/molbev/msw121
url http://hdl.handle.net/10230/33127
http://dx.doi.org/10.1093/molbev/msw121
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Molecular Biology and Evolution. 2016 Sep;33(9):2429-40
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
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repository.mail.fl_str_mv
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