Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particles

Bioresorbable highly porous polymer scaffolds play a pivotal role in tissue engineering applications. Ideally, the degradation rate of these scaffolds should match the tissue regeneration rate so that there is a gradual transfer of mechanical loads from the scaffold to the regenerated tissue. In thi...

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Autores: Larrañaga Espartero, Aitor, Aldazabal, Pablo, Martin, F. J ., Sarasua Oiz, José Ramón
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/69676
Acceso en línea:http://hdl.handle.net/10810/69676
Access Level:acceso abierto
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spelling Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particlesLarrañaga Espartero, AitorAldazabal, PabloMartin, F. J .Sarasua Oiz, José RamónBioresorbable highly porous polymer scaffolds play a pivotal role in tissue engineering applications. Ideally, the degradation rate of these scaffolds should match the tissue regeneration rate so that there is a gradual transfer of mechanical loads from the scaffold to the regenerated tissue. In this study the degradation behavior of porous and non-porous poly(l-lactide) (PLLA), poly(ε-caprolactone) (PCL) and poly(lactide-co-ε-caprolactone) (PLCL) in phosphate buffered saline (PBS) at 37 °C for a period up to 18 weeks was investigated. The calculated degradation rates (KMw) of the samples studied, from the fastest to the slowest, was: PLCL > PLLA > PCL. On the other hand, the porous structures displayed slower degradation rates with respect to their non-porous counterparts. Finally, the bioactivity of a porous PLLA scaffold filled with 0, 15 and 30 vol.% of bioactive glass particles was confirmed by the deposition of an apatite layer on the surface of the material. Even in the scaffold filled with 15 vol.% of bioactive glass particles the precipitation of the apatite layer was observed in 14 days, whereas in the scaffold with 30 vol.% of bioactive glass this layer appeared just 3 days after being submerged in simulated body fluid (SBF).The authors are thankful for funds from the Basque Government, Department of Education, Universities and Research (GIC13/161-IT-632-13) and Dept. of Health (ref. 2007111061, SAN07/01). A. L. thanks the University of the Basque Country (UPV-EHU) for a pre-doctoral grant.Elsevier202420242014info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/69676reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://doi.org/10.1016/j.polymdegradstab.2014.08.021info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/© 2014 Elsevier under CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)oai:addi.ehu.eus:10810/696762026-06-18T09:23:17Z
dc.title.none.fl_str_mv Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particles
title Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particles
spellingShingle Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particles
Larrañaga Espartero, Aitor
title_short Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particles
title_full Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particles
title_fullStr Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particles
title_full_unstemmed Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particles
title_sort Hydrolytic degradation and bioactivity of lactide and caprolactone based sponge-like scaffolds loaded with bioactive glass particles
dc.creator.none.fl_str_mv Larrañaga Espartero, Aitor
Aldazabal, Pablo
Martin, F. J .
Sarasua Oiz, José Ramón
author Larrañaga Espartero, Aitor
author_facet Larrañaga Espartero, Aitor
Aldazabal, Pablo
Martin, F. J .
Sarasua Oiz, José Ramón
author_role author
author2 Aldazabal, Pablo
Martin, F. J .
Sarasua Oiz, José Ramón
author2_role author
author
author
description Bioresorbable highly porous polymer scaffolds play a pivotal role in tissue engineering applications. Ideally, the degradation rate of these scaffolds should match the tissue regeneration rate so that there is a gradual transfer of mechanical loads from the scaffold to the regenerated tissue. In this study the degradation behavior of porous and non-porous poly(l-lactide) (PLLA), poly(ε-caprolactone) (PCL) and poly(lactide-co-ε-caprolactone) (PLCL) in phosphate buffered saline (PBS) at 37 °C for a period up to 18 weeks was investigated. The calculated degradation rates (KMw) of the samples studied, from the fastest to the slowest, was: PLCL > PLLA > PCL. On the other hand, the porous structures displayed slower degradation rates with respect to their non-porous counterparts. Finally, the bioactivity of a porous PLLA scaffold filled with 0, 15 and 30 vol.% of bioactive glass particles was confirmed by the deposition of an apatite layer on the surface of the material. Even in the scaffold filled with 15 vol.% of bioactive glass particles the precipitation of the apatite layer was observed in 14 days, whereas in the scaffold with 30 vol.% of bioactive glass this layer appeared just 3 days after being submerged in simulated body fluid (SBF).
publishDate 2014
dc.date.none.fl_str_mv 2014
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/69676
url http://hdl.handle.net/10810/69676
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.polymdegradstab.2014.08.021
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2014 Elsevier under CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
© 2014 Elsevier under CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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