Lower heart rate in patients with acute heart failure

Background: The clinical impact of heart rate (HR) in heart failure with preserved ejection fraction (HFpEF) is a matter of debate. Among those with HFpEF, chronotropic incompetence (CI) has emerged as a pathophysiological mechanism linked to the severity of the disease. In this study, we sought to...

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Autores: Lorenzo, M., Miñana, G., Palau, P., Núñez, G., de la Espriella, R., Santas, E., Villar, S., Donoso, V., Núñez, E., Sanchis, J., Bayés-Genís, Antoni|||0000-0002-3044-197X, Núñez, J.
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:311686
Acceso en línea:https://ddd.uab.cat/record/311686
https://dx.doi.org/urn:doi:10.1080/14017431.2024.2386977
Access Level:acceso abierto
Palabra clave:Heart rate
Acute heart failure
Chronotropic incompetence
Heart failure with preserved ejection fraction
Supranormal left ventricular ejection fraction
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spelling Lower heart rate in patients with acute heart failurethe role of left ventricular ejection fractionLorenzo, M.Miñana, G.Palau, P.Núñez, G.de la Espriella, R.Santas, E.Villar, S.Donoso, V.Núñez, E.Sanchis, J.Bayés-Genís, Antoni|||0000-0002-3044-197XNúñez, J.Heart rateAcute heart failureChronotropic incompetenceHeart failure with preserved ejection fractionSupranormal left ventricular ejection fractionBackground: The clinical impact of heart rate (HR) in heart failure with preserved ejection fraction (HFpEF) is a matter of debate. Among those with HFpEF, chronotropic incompetence (CI) has emerged as a pathophysiological mechanism linked to the severity of the disease. In this study, we sought to evaluate whether admission heart rate in acute heart failure differs along left ventricular ejection fraction (LVEF). Methods: We included retrospectively 3,712 consecutive patients admitted for acute heart failure (AHF) in the Cardiology department of a third level center. HR values were assessed at presentation. LVEF was assessed by transthoracic echocardiogram during the index admission and stratified into four categories: reduced ejection fraction ((Formula presented.) 40%), mildly reduced ejection fraction (41-49%), preserved ejection fraction (50-64%) and supranormal ejection fraction ((Formula presented.) 65%). The association between HR and LVEF was assessed by multivariate linear and multinomial regression analyses. Results: The mean age of the sample was 73,9 ± 11.3 years, 1,734 (47,4%) were women, and 1,214 (33,2%), 570 (15,6%), 1,229 (33,6%) and 648 (17,7%) patients showed LVEF (Formula presented.) 40%, 41-49%, 50-64%, and ≥65% respectively. The median HR at admission was 95 (IQR 78-120) beats per minute and 1,653 were on atrial fibrillation (45.2%). There was an inverse relationship between HR at admission and LVEF. Lower HR was significantly associated with a higher LVEF in the whole sample (p < 0,001). This inverse relationship was found in sinus rhythm but not in patients with atrial fibrillation. Conclusion: HR at admission for AHF is a predictor of LVEF but only in patients with sinus rhythm.Universitat Autònoma de Barcelona 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/311686https://dx.doi.org/urn:doi:10.1080/14017431.2024.2386977reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00392open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3116862026-06-06T12:50:31Z
dc.title.none.fl_str_mv Lower heart rate in patients with acute heart failure
the role of left ventricular ejection fraction
title Lower heart rate in patients with acute heart failure
spellingShingle Lower heart rate in patients with acute heart failure
Lorenzo, M.
Heart rate
Acute heart failure
Chronotropic incompetence
Heart failure with preserved ejection fraction
Supranormal left ventricular ejection fraction
title_short Lower heart rate in patients with acute heart failure
title_full Lower heart rate in patients with acute heart failure
title_fullStr Lower heart rate in patients with acute heart failure
title_full_unstemmed Lower heart rate in patients with acute heart failure
title_sort Lower heart rate in patients with acute heart failure
dc.creator.none.fl_str_mv Lorenzo, M.
Miñana, G.
Palau, P.
Núñez, G.
de la Espriella, R.
Santas, E.
Villar, S.
Donoso, V.
Núñez, E.
Sanchis, J.
Bayés-Genís, Antoni|||0000-0002-3044-197X
Núñez, J.
author Lorenzo, M.
author_facet Lorenzo, M.
Miñana, G.
Palau, P.
Núñez, G.
de la Espriella, R.
Santas, E.
Villar, S.
Donoso, V.
Núñez, E.
Sanchis, J.
Bayés-Genís, Antoni|||0000-0002-3044-197X
Núñez, J.
author_role author
author2 Miñana, G.
Palau, P.
Núñez, G.
de la Espriella, R.
Santas, E.
Villar, S.
Donoso, V.
Núñez, E.
Sanchis, J.
Bayés-Genís, Antoni|||0000-0002-3044-197X
Núñez, J.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Heart rate
Acute heart failure
Chronotropic incompetence
Heart failure with preserved ejection fraction
Supranormal left ventricular ejection fraction
topic Heart rate
Acute heart failure
Chronotropic incompetence
Heart failure with preserved ejection fraction
Supranormal left ventricular ejection fraction
description Background: The clinical impact of heart rate (HR) in heart failure with preserved ejection fraction (HFpEF) is a matter of debate. Among those with HFpEF, chronotropic incompetence (CI) has emerged as a pathophysiological mechanism linked to the severity of the disease. In this study, we sought to evaluate whether admission heart rate in acute heart failure differs along left ventricular ejection fraction (LVEF). Methods: We included retrospectively 3,712 consecutive patients admitted for acute heart failure (AHF) in the Cardiology department of a third level center. HR values were assessed at presentation. LVEF was assessed by transthoracic echocardiogram during the index admission and stratified into four categories: reduced ejection fraction ((Formula presented.) 40%), mildly reduced ejection fraction (41-49%), preserved ejection fraction (50-64%) and supranormal ejection fraction ((Formula presented.) 65%). The association between HR and LVEF was assessed by multivariate linear and multinomial regression analyses. Results: The mean age of the sample was 73,9 ± 11.3 years, 1,734 (47,4%) were women, and 1,214 (33,2%), 570 (15,6%), 1,229 (33,6%) and 648 (17,7%) patients showed LVEF (Formula presented.) 40%, 41-49%, 50-64%, and ≥65% respectively. The median HR at admission was 95 (IQR 78-120) beats per minute and 1,653 were on atrial fibrillation (45.2%). There was an inverse relationship between HR at admission and LVEF. Lower HR was significantly associated with a higher LVEF in the whole sample (p < 0,001). This inverse relationship was found in sinus rhythm but not in patients with atrial fibrillation. Conclusion: HR at admission for AHF is a predictor of LVEF but only in patients with sinus rhythm.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/311686
https://dx.doi.org/urn:doi:10.1080/14017431.2024.2386977
url https://ddd.uab.cat/record/311686
https://dx.doi.org/urn:doi:10.1080/14017431.2024.2386977
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00392
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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