Characterization and risk estimate of cancer in patients with primary Sjogren syndrome

Background: The purpose of this study is to characterize the risk of cancer in a large cohort of patients with primary Sjogren syndrome (SjS). Methods: We had analyzed the development of cancer in 1300 consecutive patients fulfilling the 2002 SjS classification criteria. The baseline clinical and im...

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Autores: Brito-Zerón, P, Kostov, B, Fraile, G, Caravia-Durán, D, Maure, B, Rascón, FJ, Zamora, M, Casanovas, A, Lopez-Dupla, M, Ripoll, M, Pinilla, B, Fonseca, E, Akasbi, M, de la Red, G, Duarte-Millán, MA, Fanlo, P, Guisado-Vasco, P, Pérez-Alvarez, R, Chamorro, AJ, Morcillo, C, Jiménez-Heredia, I, Sánchez-Berná, I, López-Guillermo, A, Ramos-Casals, M
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repositorio:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:oai:i3pt.fundanetsuite.com:p6105
Acceso en línea:https://i3pt.portalinvestigacion.com/publicaciones/6105
Access Level:acceso abierto
Palabra clave:Sjogren syndrome
Cancer
Lymphoma
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spelling Characterization and risk estimate of cancer in patients with primary Sjogren syndromeBrito-Zerón, PKostov, BFraile, GCaravia-Durán, DMaure, BRascón, FJZamora, MCasanovas, ALopez-Dupla, MRipoll, MPinilla, BFonseca, EAkasbi, Mde la Red, GDuarte-Millán, MAFanlo, PGuisado-Vasco, PPérez-Alvarez, RChamorro, AJMorcillo, CJiménez-Heredia, ISánchez-Berná, ILópez-Guillermo, ARamos-Casals, MSjogren syndromeCancerLymphomaBackground: The purpose of this study is to characterize the risk of cancer in a large cohort of patients with primary Sjogren syndrome (SjS). Methods: We had analyzed the development of cancer in 1300 consecutive patients fulfilling the 2002 SjS classification criteria. The baseline clinical and immunological characteristics and systemic activity (ESSDAI scores) were assessed at diagnosis as predictors of cancer using Cox proportional hazards regression analysis adjusted for age at diagnosis and gender. The sex-and age-specific standardized incidence ratios (SIR) of cancer were estimated from 2012 Spanish mortality data. Results: After a mean follow-up of 91 months, 127 (9.8%) patients developed 133 cancers. The most frequent type of cancer was B-cell lymphoma (including 27 MALT and 19 non-MALT B-cell lymphomas). Systemic activity at diagnosis of primary SjS correlated with the risk of hematological neoplasia and cryoglobulins with a high risk of either B-cell or non-B-cell lymphoma subtypes. Patients with cytopenias had a high risk of non-MALT B-cell and non-B-cell cancer, while those with low C3 levels had a high risk of MALT lymphomas and those with monoclonal gammopathy and low C4 levels had a high risk of non-MALT lymphomas. The estimated SIR for solid cancer was 1. 13 and 11.02 for hematological cancer. SIRs for specific cancers were 36.17 for multiple myeloma and immunoproliferative diseases, 19.41 for Hodgkin lymphoma, 6.04 for other non-Hodgkin lymphomas, 5.17 for thyroid cancer, 4.81 for cancers of the lip and oral cavity, and 2.53 for stomach cancer. Conclusions: One third of cancers developed by patients with primary SjS are B-cell lymphomas. The prognostic factors identified at SjS diagnosis differed according to the subtype of B-cell lymphoma developed. Primary SjS is also associated with the development of some non-hematological cancers (thyroid, oral cavity, and stomach).BMC2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/6105Journal of Hematology & OncologyISSN: 17568722reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p61052026-06-21T15:30:37Z
dc.title.none.fl_str_mv Characterization and risk estimate of cancer in patients with primary Sjogren syndrome
title Characterization and risk estimate of cancer in patients with primary Sjogren syndrome
spellingShingle Characterization and risk estimate of cancer in patients with primary Sjogren syndrome
Brito-Zerón, P
Sjogren syndrome
Cancer
Lymphoma
title_short Characterization and risk estimate of cancer in patients with primary Sjogren syndrome
title_full Characterization and risk estimate of cancer in patients with primary Sjogren syndrome
title_fullStr Characterization and risk estimate of cancer in patients with primary Sjogren syndrome
title_full_unstemmed Characterization and risk estimate of cancer in patients with primary Sjogren syndrome
title_sort Characterization and risk estimate of cancer in patients with primary Sjogren syndrome
dc.creator.none.fl_str_mv Brito-Zerón, P
Kostov, B
Fraile, G
Caravia-Durán, D
Maure, B
Rascón, FJ
Zamora, M
Casanovas, A
Lopez-Dupla, M
Ripoll, M
Pinilla, B
Fonseca, E
Akasbi, M
de la Red, G
Duarte-Millán, MA
Fanlo, P
Guisado-Vasco, P
Pérez-Alvarez, R
Chamorro, AJ
Morcillo, C
Jiménez-Heredia, I
Sánchez-Berná, I
López-Guillermo, A
Ramos-Casals, M
author Brito-Zerón, P
author_facet Brito-Zerón, P
Kostov, B
Fraile, G
Caravia-Durán, D
Maure, B
Rascón, FJ
Zamora, M
Casanovas, A
Lopez-Dupla, M
Ripoll, M
Pinilla, B
Fonseca, E
Akasbi, M
de la Red, G
Duarte-Millán, MA
Fanlo, P
Guisado-Vasco, P
Pérez-Alvarez, R
Chamorro, AJ
Morcillo, C
Jiménez-Heredia, I
Sánchez-Berná, I
López-Guillermo, A
Ramos-Casals, M
author_role author
author2 Kostov, B
Fraile, G
Caravia-Durán, D
Maure, B
Rascón, FJ
Zamora, M
Casanovas, A
Lopez-Dupla, M
Ripoll, M
Pinilla, B
Fonseca, E
Akasbi, M
de la Red, G
Duarte-Millán, MA
Fanlo, P
Guisado-Vasco, P
Pérez-Alvarez, R
Chamorro, AJ
Morcillo, C
Jiménez-Heredia, I
Sánchez-Berná, I
López-Guillermo, A
Ramos-Casals, M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Sjogren syndrome
Cancer
Lymphoma
topic Sjogren syndrome
Cancer
Lymphoma
description Background: The purpose of this study is to characterize the risk of cancer in a large cohort of patients with primary Sjogren syndrome (SjS). Methods: We had analyzed the development of cancer in 1300 consecutive patients fulfilling the 2002 SjS classification criteria. The baseline clinical and immunological characteristics and systemic activity (ESSDAI scores) were assessed at diagnosis as predictors of cancer using Cox proportional hazards regression analysis adjusted for age at diagnosis and gender. The sex-and age-specific standardized incidence ratios (SIR) of cancer were estimated from 2012 Spanish mortality data. Results: After a mean follow-up of 91 months, 127 (9.8%) patients developed 133 cancers. The most frequent type of cancer was B-cell lymphoma (including 27 MALT and 19 non-MALT B-cell lymphomas). Systemic activity at diagnosis of primary SjS correlated with the risk of hematological neoplasia and cryoglobulins with a high risk of either B-cell or non-B-cell lymphoma subtypes. Patients with cytopenias had a high risk of non-MALT B-cell and non-B-cell cancer, while those with low C3 levels had a high risk of MALT lymphomas and those with monoclonal gammopathy and low C4 levels had a high risk of non-MALT lymphomas. The estimated SIR for solid cancer was 1. 13 and 11.02 for hematological cancer. SIRs for specific cancers were 36.17 for multiple myeloma and immunoproliferative diseases, 19.41 for Hodgkin lymphoma, 6.04 for other non-Hodgkin lymphomas, 5.17 for thyroid cancer, 4.81 for cancers of the lip and oral cavity, and 2.53 for stomach cancer. Conclusions: One third of cancers developed by patients with primary SjS are B-cell lymphomas. The prognostic factors identified at SjS diagnosis differed according to the subtype of B-cell lymphoma developed. Primary SjS is also associated with the development of some non-hematological cancers (thyroid, oral cavity, and stomach).
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://i3pt.portalinvestigacion.com/publicaciones/6105
url https://i3pt.portalinvestigacion.com/publicaciones/6105
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv Journal of Hematology & Oncology
ISSN: 17568722
reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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