Liver and muscle circadian clocks cooperate to support glucose tolerance in mice
Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the rhythms generated by the concerted activity of these clocks is associated with metabolic disease. Here we tested the interactions between clocks in two critical components of organismal metabolism, liver an...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10230/57313 |
| Acceso en línea: | http://hdl.handle.net/10230/57313 http://dx.doi.org/10.1016/j.celrep.2023.112588 |
| Access Level: | acceso abierto |
| Palabra clave: | Bmal1 CP: Metabolism Autonomy Circadian rhythms Endocrinology Glucose Inter-organ crosstalk Liver Metabolism Muscle Systems biology |
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oai:recercat.cat:10230/57313 |
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Liver and muscle circadian clocks cooperate to support glucose tolerance in mice |
| title |
Liver and muscle circadian clocks cooperate to support glucose tolerance in mice |
| spellingShingle |
Liver and muscle circadian clocks cooperate to support glucose tolerance in mice Smith, Jacob G. Bmal1 CP: Metabolism Autonomy Circadian rhythms Endocrinology Glucose Inter-organ crosstalk Liver Metabolism Muscle Systems biology |
| title_short |
Liver and muscle circadian clocks cooperate to support glucose tolerance in mice |
| title_full |
Liver and muscle circadian clocks cooperate to support glucose tolerance in mice |
| title_fullStr |
Liver and muscle circadian clocks cooperate to support glucose tolerance in mice |
| title_full_unstemmed |
Liver and muscle circadian clocks cooperate to support glucose tolerance in mice |
| title_sort |
Liver and muscle circadian clocks cooperate to support glucose tolerance in mice |
| dc.creator.none.fl_str_mv |
Smith, Jacob G. Kumar, Arun Deryagin, Oleg Vaca Dempere, Mireia, 1994- Sica, Valentina Welz, Patrick-Simon Muñoz Cánoves, Pura, 1962- Sassone-Corsi, Paolo |
| author |
Smith, Jacob G. |
| author_facet |
Smith, Jacob G. Kumar, Arun Deryagin, Oleg Vaca Dempere, Mireia, 1994- Sica, Valentina Welz, Patrick-Simon Muñoz Cánoves, Pura, 1962- Sassone-Corsi, Paolo |
| author_role |
author |
| author2 |
Kumar, Arun Deryagin, Oleg Vaca Dempere, Mireia, 1994- Sica, Valentina Welz, Patrick-Simon Muñoz Cánoves, Pura, 1962- Sassone-Corsi, Paolo |
| author2_role |
author author author author author author author |
| dc.subject.none.fl_str_mv |
Bmal1 CP: Metabolism Autonomy Circadian rhythms Endocrinology Glucose Inter-organ crosstalk Liver Metabolism Muscle Systems biology |
| topic |
Bmal1 CP: Metabolism Autonomy Circadian rhythms Endocrinology Glucose Inter-organ crosstalk Liver Metabolism Muscle Systems biology |
| description |
Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the rhythms generated by the concerted activity of these clocks is associated with metabolic disease. Here we tested the interactions between clocks in two critical components of organismal metabolism, liver and skeletal muscle, by rescuing clock function either in each organ separately or in both organs simultaneously in otherwise clock-less mice. Experiments showed that individual clocks are partially sufficient for tissue glucose metabolism, yet the connections between both tissue clocks coupled to daily feeding rhythms support systemic glucose tolerance. This synergy relies in part on local transcriptional control of the glucose machinery, feeding-responsive signals such as insulin, and metabolic cycles that connect the muscle and liver. We posit that spatiotemporal mechanisms of muscle and liver play an essential role in the maintenance of systemic glucose homeostasis and that disrupting this diurnal coordination can contribute to metabolic disease. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023 2023 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/57313 http://dx.doi.org/10.1016/j.celrep.2023.112588 |
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http://hdl.handle.net/10230/57313 http://dx.doi.org/10.1016/j.celrep.2023.112588 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
| dc.relation.none.fl_str_mv |
Cell Rep. 2023 Jun 1;42(6):112588 info:eu-repo/grantAgreement/EC/H2020/749869 info:eu-repo/grantAgreement/EC/H2020/787041 info:eu-repo/grantAgreement/EC/H2020/741966 info:eu-repo/grantAgreement/EC/H2020/825825 |
| dc.rights.none.fl_str_mv |
http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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application/pdf application/pdf |
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Elsevier |
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Elsevier |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869422734816051200 |
| spelling |
Liver and muscle circadian clocks cooperate to support glucose tolerance in miceSmith, Jacob G.Kumar, ArunDeryagin, OlegVaca Dempere, Mireia, 1994-Sica, ValentinaWelz, Patrick-SimonMuñoz Cánoves, Pura, 1962-Sassone-Corsi, PaoloBmal1CP: MetabolismAutonomyCircadian rhythmsEndocrinologyGlucoseInter-organ crosstalkLiverMetabolismMuscleSystems biologyPhysiology is regulated by interconnected cell and tissue circadian clocks. Disruption of the rhythms generated by the concerted activity of these clocks is associated with metabolic disease. Here we tested the interactions between clocks in two critical components of organismal metabolism, liver and skeletal muscle, by rescuing clock function either in each organ separately or in both organs simultaneously in otherwise clock-less mice. Experiments showed that individual clocks are partially sufficient for tissue glucose metabolism, yet the connections between both tissue clocks coupled to daily feeding rhythms support systemic glucose tolerance. This synergy relies in part on local transcriptional control of the glucose machinery, feeding-responsive signals such as insulin, and metabolic cycles that connect the muscle and liver. We posit that spatiotemporal mechanisms of muscle and liver play an essential role in the maintenance of systemic glucose homeostasis and that disrupting this diurnal coordination can contribute to metabolic disease.This paper is dedicated to Paolo Sassone-Corsi, a hugely inspiring scientist and mentor who remains an important influence on our work. We also thank P.S.C. Lab animal technician S. Sato and laboratory manager W. Orquiz for their valued contributions, as well as Aintzane Rueda and Alfonso Saera-Vila at Sequentia Biotech (Barcelona) for their work on RNA sequencing read alignment and differential gene expression analysis. J.G.S. was supported by Zymo-CEM Postdoctoral Fellowship (Zymo Research) awarded at the University of California, Irvine. K.B.K. was supported by NIH, NIDDK F32 Fellowship – DK121425. T.S. was supported by a Japan Society for the Promotion of Science (JSPS) fellowship. C.M.G. was supported by the National Cancer Institute of the National Institutes of Health under award T32CA009054 and by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement 749869. P.P. was funded by The Wenner-Gren Foundations, the Foundation Blanceflor Boncompagni Ludovisi, née Bildt and Tore Nilsson Foundation for Medical Science. V.S. was supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement 895390. A.V. was supported by the Hitachi-Nomura postdoctoral fellowship awarded through the Department of Biological Chemistry at the University of California, Irvine. The work of S.C., M.S., and P.B. was in part supported by NIH grant GM123558. C.J. was supported by the AASLD Foundation Pinnacle Research Award in Liver Disease, the Edward Mallinckrodt, Jr. Foundation Award, and NIH/NIAAA R01 AA029124. P.-S.W. is supported by grant RYC2019026661-I funded by MCIN/AEI/10.13039/501100011033 and by “ESF Investing in your future.” Financial support for the S.M. laboratory is provided through the NIH/NCI (grants R01CA244519, R01CA259370, and K22CA212045). Research in the S.A.B. lab is supported partially by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement 787041), the Government of Cataluña (SGR grant), the Government of Spain (MINECO), the La Marató/TV3 Foundation, the Foundation Lilliane Bettencourt, the Spanish Association for Cancer Research (AECC), and the Worldwide Cancer Research Foundation (WCRF). The IRB Barcelona is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). P.M.-C. acknowledges funding from MICINN-RTI2018-096068, ERC-2016-AdG-741966, LaCaixa-HEALTH-HR17-00040, MDA, UPGRADE-H2020-825825, AFM, DPP-Spain, Fundació La MaratóTV3- 80/19-202021, MWRF, and María-de-Maeztu Program for Units of Excellence to UPF (MDM-2014-0370), and the Severo-Ochoa Program for Centers of Excellence to CNIC (SEV2015-0505). Work in the P.S.-C. laboratory is supported by NIH grants R21DK114652 and R21AG053592, a Challenge Grant from the Novo Nordisk Foundation (NNF202585), KAUST funding (OSR-2019-CRG8-URF/1/4042), and via access to the Genomics High Throughput Facility Shared Resource of the Cancer Center Support Grant (CA-62203) and the UCI and NIH-shared instrumentation grants 1S10RR025496-01, 1S10OD010794-01, and 1S10OD021718-01.Elsevier202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/57313http://dx.doi.org/10.1016/j.celrep.2023.112588reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCell Rep. 2023 Jun 1;42(6):112588info:eu-repo/grantAgreement/EC/H2020/749869info:eu-repo/grantAgreement/EC/H2020/787041info:eu-repo/grantAgreement/EC/H2020/741966info:eu-repo/grantAgreement/EC/H2020/825825© 2023 The Author(s). This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:10230/573132026-05-29T05:05:01Z |
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15.81155 |