Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance

Background: Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis...

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Autores: Contreras Rodríguez, Oren, Arnoriaga Rodríguez, María, Miranda Olivos, Romina, Blasco, Gerard, Biarnés, Carles, Puig, Josep, Rivera Pinto, Javier, Calle, María Luz, Pérez Brocal, Vicente, Moya, Andrés, Coll Martinez, Clàudia, Ramió Torrentà, Lluís, Soriano Mas, Carles, Fernandez Real, Jose M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/180095
Acceso en línea:https://hdl.handle.net/2445/180095
Access Level:acceso abierto
Palabra clave:Obesitat
Glàndules endocrines
Obesity
Endocrine glands
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spelling Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covarianceContreras Rodríguez, OrenArnoriaga Rodríguez, MaríaMiranda Olivos, RominaBlasco, GerardBiarnés, CarlesPuig, JosepRivera Pinto, JavierCalle, María LuzPérez Brocal, VicenteMoya, AndrésColl Martinez, ClàudiaRamió Torrentà, LluísSoriano Mas, CarlesFernandez Real, Jose M.ObesitatGlàndules endocrinesObesityEndocrine glandsBackground: Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms. Methods: Medial (MH) and lateral (LH) hypothalamic structural covariance alterations were identified in 57 subjects with obesity compared to 47 subjects without obesity. Gut dysbiosis in the subjects with obesity was defined by the presence of high (n = 28) and low (n = 29) values in a BMI-associated microbial signature, and posthoc comparisons between these groups were used as a proxy to explore the role of obesity-related gut dysbiosis on the hypothalamic measurements, executive function, and depressive symptoms. Results: Structural covariance alterations between the MH and the striatum, lateral prefrontal, cingulate, insula, and temporal cortices are congruent with previously functional connectivity disruptions in obesity conditions. MH structural covariance decreases encompassed postcentral parietal cortices in the subjects with obesity and gut-dysbiosis, but increases with subcortical nuclei involved in the coding food-related hedonic information in the subjects with obesity without gut-dysbiosis. Alterations for the structural covariance of the LH in the subjects with obesity and gut-dysbiosis encompassed increases with frontolimbic networks, but decreases with the lateral orbitofrontal cortex in the subjects with obesity without gut-dysbiosis. Subjects with obesity and gut dysbiosis showed higher executive dysfunction and depressive symptoms. Conclusions: Obesity-related gut dysbiosis is linked to specific structural covariance alterations in hypothalamic networks relevant to the integration of somatic-visceral information, and emotion regulation.Springer Science and Business Media LLC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/180095Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1038/s41366-021-00953-9International Journal of Obesity, 2021https://doi.org/10.1038/s41366-021-00953-9cc by (c) Contreras Rodríguez, Oren et al, 2021http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1800952026-05-27T06:46:51Z
dc.title.none.fl_str_mv Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
title Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
spellingShingle Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
Contreras Rodríguez, Oren
Obesitat
Glàndules endocrines
Obesity
Endocrine glands
title_short Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
title_full Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
title_fullStr Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
title_full_unstemmed Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
title_sort Obesity status and obesity-associated gut dysbiosis effects on hypothalamic structural covariance
dc.creator.none.fl_str_mv Contreras Rodríguez, Oren
Arnoriaga Rodríguez, María
Miranda Olivos, Romina
Blasco, Gerard
Biarnés, Carles
Puig, Josep
Rivera Pinto, Javier
Calle, María Luz
Pérez Brocal, Vicente
Moya, Andrés
Coll Martinez, Clàudia
Ramió Torrentà, Lluís
Soriano Mas, Carles
Fernandez Real, Jose M.
author Contreras Rodríguez, Oren
author_facet Contreras Rodríguez, Oren
Arnoriaga Rodríguez, María
Miranda Olivos, Romina
Blasco, Gerard
Biarnés, Carles
Puig, Josep
Rivera Pinto, Javier
Calle, María Luz
Pérez Brocal, Vicente
Moya, Andrés
Coll Martinez, Clàudia
Ramió Torrentà, Lluís
Soriano Mas, Carles
Fernandez Real, Jose M.
author_role author
author2 Arnoriaga Rodríguez, María
Miranda Olivos, Romina
Blasco, Gerard
Biarnés, Carles
Puig, Josep
Rivera Pinto, Javier
Calle, María Luz
Pérez Brocal, Vicente
Moya, Andrés
Coll Martinez, Clàudia
Ramió Torrentà, Lluís
Soriano Mas, Carles
Fernandez Real, Jose M.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Obesitat
Glàndules endocrines
Obesity
Endocrine glands
topic Obesitat
Glàndules endocrines
Obesity
Endocrine glands
description Background: Functional connectivity alterations in the lateral and medial hypothalamic networks have been associated with the development and maintenance of obesity, but the possible impact on the structural properties of these networks remains largely unexplored. Also, obesity-related gut dysbiosis may delineate specific hypothalamic alterations within obese conditions. We aim to assess the effects of obesity, and obesity and gut-dysbiosis on the structural covariance differences in hypothalamic networks, executive functioning, and depressive symptoms. Methods: Medial (MH) and lateral (LH) hypothalamic structural covariance alterations were identified in 57 subjects with obesity compared to 47 subjects without obesity. Gut dysbiosis in the subjects with obesity was defined by the presence of high (n = 28) and low (n = 29) values in a BMI-associated microbial signature, and posthoc comparisons between these groups were used as a proxy to explore the role of obesity-related gut dysbiosis on the hypothalamic measurements, executive function, and depressive symptoms. Results: Structural covariance alterations between the MH and the striatum, lateral prefrontal, cingulate, insula, and temporal cortices are congruent with previously functional connectivity disruptions in obesity conditions. MH structural covariance decreases encompassed postcentral parietal cortices in the subjects with obesity and gut-dysbiosis, but increases with subcortical nuclei involved in the coding food-related hedonic information in the subjects with obesity without gut-dysbiosis. Alterations for the structural covariance of the LH in the subjects with obesity and gut-dysbiosis encompassed increases with frontolimbic networks, but decreases with the lateral orbitofrontal cortex in the subjects with obesity without gut-dysbiosis. Subjects with obesity and gut dysbiosis showed higher executive dysfunction and depressive symptoms. Conclusions: Obesity-related gut dysbiosis is linked to specific structural covariance alterations in hypothalamic networks relevant to the integration of somatic-visceral information, and emotion regulation.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/180095
url https://hdl.handle.net/2445/180095
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41366-021-00953-9
International Journal of Obesity, 2021
https://doi.org/10.1038/s41366-021-00953-9
dc.rights.none.fl_str_mv cc by (c) Contreras Rodríguez, Oren et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Contreras Rodríguez, Oren et al, 2021
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Science and Business Media LLC
publisher.none.fl_str_mv Springer Science and Business Media LLC
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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